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Lijun Bi, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of RNA Biology
Tuberculosis Systems Biology and Translational Medicine
Prof Bi’s work focuses on problems encountered in the diagnosis and treatment of tuberculosis, including the poor detection rate of TB, the rise of drug resistance, the poor protection afforded by current vaccines, and the lack of drugs for treating latent TB infections.  More ...
   
   
Pengcheng Bi, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of RNA Biology
Non-coding RNA in disease; metabolism and cancer
Non-coding RNAs (ncRNAs) such as microRNAs and long non-coding RNAs (lncRNAs) occupy the bulk of the genome, but their functions are often obscure. Global dysregulation of microRNAs and lncRNAs in cancers have been consistently reported, though ncRNA deletions often generate no phenotypes in normal tissue homeostasis. More...
   
   
  Huaqing Cai, Ph.D., Prof.
IBP Division -National Laboratory of Biomacromolecules
Molecular mechanisms of cell migration and chemotaxis 
Cells have remarkable abilities to sense and respond to environmental cues. Not only the identity but the spatial and temporal dynamics of external signals encodes rich information. Spatial signaling is central to chemotaxis (directed cell migration along external chemical gradients),  More ...
   
   
   
 
Peng Cao, Ph.D, Prof. (guest)
IBP Division - State Key Laboratory of Brain & Cognitive Sciences
Brain neurodegenerative disorders and neuropsychiatric disorders.
In this laboratory, we are studying two major classes of brain disease: neurodegenerative disorders and neuropsychiatric disorders, using methods including molecular genetics, electrophysiology, live-cell imaging, behavioral analysis, neural stem cell biology, deep sequencing and drug virtual screening.  More ... 
   
   
Chang Chen, Ph.D, Prof.
IBP Division - National Laboratory of Biomacromolecules
Nitric oxide and S-nitros(yl)ation, SNO/thiol modification and the functions of GSNOR and PI4KIIα.
Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency result in impaired homeostasis and is associated with pathology, such as ageing-related diseases, More ... 
   
   
 
Hongyu Deng, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
Replication mechanisms of viruses and virus-host interactions
Dr. Deng has spent much of her career studying viruses that are causative agents for tumors. Her main research interests are to investigate the replication mechanisms of viruses and virus-host interactions, so as to gain insights into viral pathogenesis and to develop better therapeutics and diagnosis. More ...
   
   
Xianzhi Dong, Ph.D, Prof.
Institute of Biophysics Key Laboratory of Interdisciplinary Research, IBP
   
   
 
Zusen Fan, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
NK/CTL-mediated killing mechanisms against cancers and viruses; Genetic and signaling regulation for directed development and differentiation of NK cells;Cancer stem cell, biomarker identification, immunotherapy and personalized therapy for cancers.
Fan Lab focuses on these major research fields: 1) NK/CTL-mediated killing mechanisms against cancers and viruses; 2) Genetic and signaling regulation for directed development and differentiation of NK cells; 3) Cancer stem cell, biomarker identification, immunotherapy and personalized therapy for cancers. More ...
   
   
 
Wei Feng, Ph.D, Prof.
IBP Division - National Laboratory of Biomacromolecules
Structural biology of cell polarity regulation and intracellular transport
On the basis of NMR spectroscopy and X-ray crystallography, we focus on the structural and functional studies of protein complexes that are involved in the control of the cell polarity and molecular motors that play prominent roles in regulating intracellular transport. More ...
   
   
Xiang-Dong Fu, Ph.D,  Prof. (guest)
IBP Division - Chinese Academy of Sciences Key Laboratory of RNA Biology
RNA processing and gene expression regulation
Research in our laboratory is focused on RNA biology, RNA can convey genetic information as well as catalyze biological reactions. Recently, small noncoding RNA, represented by miRNA and piRNA, as the regulatory element in gene expression, play important regulatory role incell activitiesand development process of individuals. More ... 
   
   
 
Yangxin Fu, Ph.D, Prof. (guest)
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
Cancer Immunotherapy
The major research interest of Fu lab is to explore new immunological therapeutic strategies for cancer and chronic infection using antibody-based strategies and therapeutic vaccines. Our lab has made significant progress in understanding how traditional cancer therapies both rely on and impact the immune system. More... 
   
   
 
Guangxia Gao, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
Mechanistic studies on HIV-host interactions
Our research mainly focuses on the molecular mechanism underlying retrovirus-host interaction. Using a high-throughout genetic screening system, we cloned a host antiviral factor named Zinc-finger Antiviral Protein (ZAP). In-depth mechanistic studies on ZAP in our lab revealed that ZAP specifically binds to viral mRNA, More ...
   
   
 
Pu Gao, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
Innate immunity and host-pathogen interaction
The major research interest in our group is the structural immunology. By using a combined approach including structural biology, biochemistry, and cellular biology, we are trying to understand the molecular mechanisms of infection and immunity and design small molecular drugs. In the recent five years, More ...
   
   
 
Weimin Gong, Ph.D, Prof. (guest)
IBP Division - Chinese Academy of Sciences Key Laboratory of RNA Biology
Structural biology studies of protein/RNA complexes
Our research interests are the structural biology studies of protein-nucleic acid complexes involved in DNA repair and transcription regulation. We’re focusing on the structure bases and functional mechanisms of Fancconi disease, ALS and nucleic receptors.  Moer ...
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