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Lijun Bi, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of RNA Biology
Tuberculosis Systems Biology and Translational Medicine
Prof Bi’s work focuses on problems encountered in the diagnosis and treatment of tuberculosis, including the poor detection rate of TB, the rise of drug resistance, the poor protection afforded by current vaccines, and the lack of drugs for treating latent TB infections.  More ...
   
   
Pengcheng Bu, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of RNA Biology
Non-coding RNA in disease; metabolism and cancer
Non-coding RNAs (ncRNAs) such as microRNAs and long non-coding RNAs (lncRNAs) occupy the bulk of the genome, but their functions are often obscure. Global dysregulation of microRNAs and lncRNAs in cancers have been consistently reported, though ncRNA deletions often generate no phenotypes in normal tissue homeostasis. More...
   
   
  Huaqing Cai, Ph.D, Prof.
IBP Division - National Laboratory of Biomacromolecules
Molecular mechanisms of cell migration and chemotaxis 
Cells have remarkable abilities to sense and respond to environmental cues. Not only the identity but the spatial and temporal dynamics of external signals encodes rich information. Spatial signaling is central to chemotaxis (directed cell migration along external chemical gradients),  More ...
   
   
Chang Chen, Ph.D, Prof.
IBP Division - National Laboratory of Biomacromolecules 
Nitric oxide and S-nitros(yl)ation, SNO/thiol modification and the functions of GSNOR and PI4KIIα.
Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency result in impaired homeostasis and is associated with pathology, such as ageing-related diseases, More ... 
   
   
 
Hongyu Deng, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
Replication mechanisms of viruses and virus-host interactions
Dr. Deng has spent much of her career studying viruses that are causative agents for tumors. Her main research interests are to investigate the replication mechanisms of viruses and virus-host interactions, so as to gain insights into viral pathogenesis and to develop better therapeutics and diagnosis. More ...
   
   
 
Jingjin Ding, Ph.D, Prof.
IBP Division - National Laboratory of Biomacromolecules
Molecular mechanism of pathogen infection and host innate immune defense
Pathogen infection and host innate immunity are important manifestations of the pathogen-host interaction, in which the key scientific question is to understand the molecular mechanisms of pathogen infection, immune recognition and response. Our group systematically studied the molecular basis of host innate immunity More ...
   
   
Xianzhi Dong, Ph.D, Prof.
IBP Division - Institute of Biophysics Key Laboratory of Interdisciplinary Research
   
   
 
Zusen Fan, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
Institute NK/CTL-mediated killing mechanisms against cancers and viruses; Genetic and signaling regulation for directed development and differentiation of NK cells;Cancer stem cell, biomarker identification, immunotherapy and personalized therapy for cancers.
Fan Lab focuses on these major research fields: 1) NK/CTL-mediated killing mechanisms against cancers and viruses; 2) Genetic and signaling regulation for directed development and differentiation of NK cells; 3) Cancer stem cell, biomarker identification, immunotherapy and personalized therapy for cancers. More ...
   
   
 
Wei Feng, Ph.D, Prof.
IBP Division - National Laboratory of Biomacromolecules
Structural biology of cell polarity regulation and intracellular transport.
On the basis of NMR spectroscopy and X-ray crystallography, we focus on the structural and functional studies of protein complexes that are involved in the control of the cell polarity and molecular motors that play prominent roles in regulating intracellular transport. More ...
   
   
 
Guangxia Gao, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
Mechanistic studies on HIV-host interactions
Our research mainly focuses on the molecular mechanism underlying retrovirus-host interaction. Using a high-throughout genetic screening system, we cloned a host antiviral factor named Zinc-finger Antiviral Protein (ZAP). In-depth mechanistic studies on ZAP in our lab revealed that ZAP specifically binds to viral mRNA, More ...
   
   
 
Pu Gao, Ph.D, Prof.
IBP Division - Chinese Academy of Sciences Key Laboratory of Infection and Immunity
Innate immunity and host-pathogen interaction
The major research interest in our group is the structural immunology. By using a combined approach including structural biology, biochemistry, and cellular biology, we are trying to understand the molecular mechanisms of infection and immunity and design small molecular drugs. In the recent five years, More ...
   

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