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Wei Feng, Ph.D, Prof.

Principal Investigator

National Laboratory of Biomacromolecules, IBP

Structural biology of cell polarity regulation and intracellular transport

E-mail:wfeng@ibp.ac.cn,Tel:010-64888751, 010-64888853

Fax:010-64888237,Zip code:100101

Chinese personal homepage   

Biography & Introduction  

1997-2001  B.Sc. in Chemistry, Fudan University

2001-2005  Ph.D. in Biochemistry, Hong Kong University of Science and Technology (HKUST)

2005-2007  Postdoctoral Research Associate, Department of Biochemistry, HKUST

2007-2009  Research Assistant Professor, Department of Biochemistry, HKUST

2009-      Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences

Research Interests

On the basis of NMR spectroscopy and X-ray crystallography, we focus on the structural and functional studies of protein complexes that are involved in the control of the cell polarity and molecular motors that play prominent roles in regulating intracellular transport.

1. Structural dissection of protein complexes involved in the control of cell polarity

Polarization of cells is a fundamental process vital for a variety of biological activities such as embryonic asymmetric cell division, epithelial differentiation, neuronal development, and cancer cell migration. Both establishment and maintenance of cell polarity are complicated processes and rigorously regulated by a number of protein complexes. These protein complexes are evolutionally conserved and restrictedly distributed at the specific cell cortex acting as hallmarks of cellular polarization. We focus on the structural and functional dissection of these protein complexes, and aim to investigate how these protein complexes assemble and what’s the biological significance for regulating cell polarity. The results of our research will provide mechanistic insights into the organization of cell polarity-regulatory protein complexes and may also hopefully generalize some rules for the establishment and maintenance of cell polarity.

2. Structural basis for molecular motor-mediated intracellular transport

Intracellular transport is a fundamental biological process responsible for delivering, exchanging, and recycling of biological materials within cells. Dysfunction of this process is coupled with a large number of pathological diseases. Molecular motors are cytoskeleton-based biological molecular machines capable of carrying cargo vesicles and walking along the cytoskeletons, and thus function as core components for intracellular transport. We work on the structural and functional studies of molecular motors, and are mainly interested in how the activity of molecular motors is exquisitely regulated in terms of the monomer-dimer conversion and the motor activation-inactivation. Our overall research will provide the molecular mechanism for the motor regulation and may also shed some light on molecular motor-mediated intracellular transport.

Selected Publications 

1. Xu, Y., Ren, J., He, X., Chen, H., Wei, T.*, and Feng, W.*,(2019). "YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. " Autophagy (DOI: 10.1080/15548627.2019.1569928). (*: corresponding authors)

2. Liang, R., Ren, J., Zhang, Y., and Feng, W.*, (2019). "Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins. " J Mol Biol 431 (7): 1494-1505.(*: corresponding authors)

3. Ren, J., Wang, S., Chen, H., Wang, W., Huo, L., and Feng, W.*, (2018). "Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition. " Proc Natl Acad Sci U S A 115(51): E11933-E11942 (*: corresponding authors)

4. Ren, J., Zhang, Y., Wang, S., Huo, L., Lou, J., and Feng, W.*, (2018). "Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. " J Mol Biol 430(14):2030-2041. (*: corresponding authors)

5. Yi, F., Kong, R., Ren, J., Zhu, L., Lou, J., Wu, J.Y., and Feng, W.*, (2016) "Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism" J Mol Biol. 428(15): 3043-57. (*: corresponding authors)

6. Ren, J., Huo, L., Wang, W., Zhang, Y., Li, W., Lou, J., Xu, T., and Feng, W.*, (2016) "Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A" J Biol Chem. 291(7): 3581-94.(*: corresponding authors)

7. Nie, S., Ke, H., Gao, F., Ren, J., Wang, M., Huo, L., Gong, W., and Feng, W.*, (2016) "Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators" Structure. 24(1): 80-91.(*: corresponding authors)

8. Ren, J., Feng, L., Bai, Y., Pei, H., Yuan, Z., and Feng, W.*, (2015) "Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule" Biochem J. 468(1): 133-44.(*: corresponding authors)

9. Kong, R., Yi, F., Wen, P., Liu, J., Chen, X., Ren, J., Li, X., Shang, Y., Nie, Y., Wu, K., Fan, D., Zhu, L.*, Feng, W.*, and Wu, J.Y.*, (2015) "Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression" J Clin Invest. 125(12): 4407-20.(*: corresponding authors)

10. Zhang, Y., Wang, W., Chen, J., Zhang, K., Gao, F., Gao, B., Zhang, S., Dong, M., Besenbacher, F., Gong, W., Zhang, M., Sun, F.*, and Feng, W.*, (2013) "Structural insights into the intrinsic self-assembly of Par-3 N-terminal domain" Structure. 21(6): 997-1006.(*: corresponding authors)

11. Wang, C., Li, W., Ren, J., Fang, J., Ke, H., Gong, W., Feng, W.*, and Wang, C.C.*, (2013) "Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase" Antioxid Redox Signal. 19(1): 36-45.(*: corresponding authors)

12. Huo, L., Yue, Y., Ren, J., Yu, J., Liu, J., Yu, Y., Ye, F., Xu, T.*, Zhang, M.*, and Feng, W.*, (2012) "The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A" Structure. 20(9): 1550-61.(*: corresponding authors)

13. Huo, L., Wen, W., Wang, R., Kam, C., Xia, J., Feng, W.*, and Zhang, M.*, (2011) "Cdc42-dependent formation of the ZO-1/MRCKb complex at the leading edge controls cell migration" EMBO J. 30(4): 665-78.(*: corresponding authors)

14. Yu, C.#, Feng, W.#, Wei, Z., Miyanoiri, Y., Wen, W., Zhao, Y., and Zhang, M., (2009) "Myosin VI undergoes cargo-mediated dimerization" Cell. 138(3): 537-48. (#: co-first authors)

15. Feng, W. and Zhang, M., (2009) "Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density" Nat Rev Neurosci. 10(2): 87-99.(invited review)

16. Wu, H.#, Feng, W.#, Chen, J., Chan, L.N., Huang, S., and Zhang, M., (2007) "PDZ domains of Par-3 as potential phosphoinositide signaling integrators" Mol Cell. 28(5): 886-98. (#: co-first authors)


From Wei Feng, 2019-04-10 update


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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
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