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  Chang Chen, Ph.D, Prof.

  Principal Investigator, National Laboratory of Biomacromolecules, IBP

  Aging, Redox, Chinese traditional medicine

  E-mail:changchen@moon.ibp.ac.cn,Tel:010-64888406

  Fax:010-6488406,Zip code:100101

  Chinese personal homepage  

Biography & Introduction

1986-1990  B.S.,  Nankai University, Tianjin, China

1990-1993  M.S.,  Beijing Normal University, Beijing, China

1993-1996  Ph.D.,  Peking University, Beijing, China

1996-1998  Assistant Professor, Institute of Biophysics, CAS

1998-2000  Associate Professor, Institute of Biophysics, CASVisiting Scientist in the Institute of Food Research, Norwich, UK (The Royal Society K.C. Wong Research Fellowship)

2000-Present  Principle Investigator (PI ) (2004, full professor. Institute of Biophysics, CAS.)

2004-2005  Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK

Professional activities

Vice Director of National Laboratory of Biomacromolecules

Professor of University of Chinese Academy of Sciences

Chief Scientist of “National Basic Research Program of China, 973 Program”

Vice President of the Commission for Free Radical Biology and Medicine of the Biophysical Society of China

Council Member of International Society for Free Radical Research, -Asia

Editorial Board Member, Free Radical Research and Redox Biology

Associate Editor, Acta Biophysica Sinica

Deputy General Secretaryn and executive member of the council of The Biophysical Society of China

Council Member of The Chinese Society of Biochemistry and Molecular Biology

Awards and Honors

2015  Special Government Allowances of the State Council

2014  Outstanding Contribution, CAS-Beijing

2012  National Outstanding Young Scientists

2006  Young Scientist Award Society for Free Radical Research (SFRR)-Asia

Research Interest

Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency result in impaired homeostasis and is associated with pathology, such as ageing-related diseases, malignant transformation, atherosclerosis, neurodegenerative diseases, obesity, and diabetes. Our research has been focused on the crosstalk between these small molecules and macromolecules, trying to explore the relationship between protein function and cellular redox status. We aim to explore the relationship between protein function and cellular redox status, which is one fundamental question in Redox Biology. To reach this goal, we are going to demonstrate cellular Redox network, draw cellular Redox map and illustrate Redox response including oxidative stress and reductive stress. Based on it, try to find out effective approach, such as Chinese medicine, to maintain cellular redox homeostasis and apply for healthy aging and treatment for redox related disease.

The Ongoing Projects:

1. Redox network - Redox map - Redox response: whole genome redox gene screening and protein thiol modification in cellular quality control and physiopathology process.

2. Redox stress and Aging: explore the roles of "Redox-stress Adaptive capacity (RAC)", reductive stress (RS) and redox status of different organelles in aging and related disease.

3. Function mechanism of S-nitrosoglutathione reductase (GSNOR) and phosphatidylinositol 4-kinase type IIα (PI4KIIα): study GSNOR in cognitive impairment and PI4KIIα in tumor and the specific inhibitor application.

Selected Publications (*as the corresponding author)

1. Meng, J., Lv, Z.Y., Qiao, X.H., Li, X.P., Li, Y.Z. & Chen, C.* (2017). The decay of Redox-stress Adaptive Capacity is a substantive characteristic of aging: revising the redox theory of aging. Redox Bio.11,365-374.

2. Zhang, H., Yang, J., Si, W., Gong, W., Chen, C.* & Perrett, S.* (2016). Glutathionylation of DnaK provides a link between oxidative stress and the heat shock response. J. Biol. Chem. 291, 6967-6981.

3. Gao, L., Zhang, Y.Y., Wang Y., Qiao X.H., Zi, J., Chen, C.* & Wan, Y.* (2016) . Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa. Redox Bio. 8, 252–258.

4. Yin, R.Y., Fang, Li., Li, Y.J., Xue P., Li Y.Z., Guan Y.F., Chang Y.S., Chen, C.* & Wang, N.P.* (2015). Pro- inflammatory Macrophages suppress PPARγ activity in Adipocytes via S-nitrosylation. Free Radic. Biol. Med. 89, 895-905.

5. Qiao, X.H., HU, M.X., Zhang, Y.Y., Li Y.Z.& Chen, C.* (2015). Cellular redox regulation and thiol modification. Chinese Bulletin of Life Sciences 27(3), 374-382.

6. Zhou, Q.J., Li, J.M., Yu, H., Zhai, Y.J., Gao, Z., Liu, Y.X., Pang, X.Y., Zhang, L.F., Schulten, K*., Sun, F*. & Chen, C.* (2014).Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nat. Commun. 5, 35-52.

7. Li, J.M., Zhang, L.F., Gao, Z., Kang, H., Rong, G., & Chen, C.* (2014). Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα and EGFR as anti-tumor strategy. Protein & Cell 5(6), 457-468.

8. Wu, K., Ren, R., Su, W., Wen, B., Zhang, Y., Yi, F., Qiao, X., Yuan, T., Wang, J., Liu, L., Belmonte J.*, Liu, G*. & Chen, C.* (2014). A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J. Biol. Chem. 289, 20193-20199.

9. Wu, K., Zhang, Y., Wang, P., Zhang, L., Wang, T. & Chen, C.* (2014). Activation of GSNOR transcription by NF-kappaB negatively regulates NGF-induced PC12 differentiation. Free Radical Res. 48(9), 1011-1017.

10. Mao, K.R., Chen, S.Z., Chen, M.K., Ma, Y.L., Wang, Y., Huang, B., He, Z.Y., Zeng, Y., Hu, Y., Sun, S.H., Li, J., Wu, X.D., Wang, X.R., Strober, W., Chen, C.*, Meng, G.X.* & Sun. B. * (2013). Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res. 23, 201-212.

11. Zhang, X., Huang, B., Zhang, L., Zhang, Y.Y., Zhao, Y.Y., Guo, X.F., Qiao, X.H. & Chen, C.* (2012). SNObase, a database for S-nitrosation modification. Protein & Cell 3(12), 929-933.

12. Hou, Q.L., Jiang, H.Q., Zhang, X., Guo, C., Huang, B., Wang, P., Wang, T.P., Wu, K.K., Li, J., Gong, Z.F., Du, L.B., Liu, Y., Liu, L. & Chen, C.* (2011). Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila. Nitric Oxide-Bio. Chem. 24, 17-24.

13. Zhang, X., Huang, B., Zhou, X.X. & Chen, C.* (2010). Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method. Protein & Cell 1(7), 675-687.

14. Huang, B. & Chen, C.* (2010). Detection of protein S-Nitrosation using irreversible biotinylation procedures (IBP). Free Radic. Biol. Med. 49, 447-456.

15. Li, J.M., Lu, Y., Zhang, J.H., Kang, H., Qin, Z.H.* & Chen, C.* (2010). PI4KIIα is a novel regulator of tumor growth via its action on angiogenesis and HIF-1α regulation. Oncogene 29, 2550-2559.

16. Wang, P., Liu, G.H.* Wu, K.Y., Qu, J., Huang, B., Zhang, X., Zhou, X.X. & Chen, C.* (2009). Repression of classical nuclear export by S-nitrosylation of CRM1. J. Cell Sci. 20(122), 3772-3779.

17. Qu, J., Liu, G.H.* Wu, K.Y., Han, P.W., Wang, P., Li, J.M., Zhang, X.,& Chen, C.* (2007). Nitric oxide destabilizes pias3 and regulates sumoylation. PLoS One 2(10), e1085.

18. Qu, J., Liu, G.H., Huang, B. & Chen, C.* (2007). Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310. Nucleic Acids Research 8(35), 2522-2532.

19. He, J., Wang, T.P., Wang, P., Han, P.W.& Chen, C.* (2007). A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: the occurrence and regulation of protein S-nitrosylation is the checkpoint. J. Neurochem. 6(102): 1863-1874.

Patents

1. Chang Chen, Bo Huang “A specific method for detection of thiol modification and its application”. Patent number: ZL200910084155.7.

2. Chang Chen, Jiangmei Li “The application of Phosphatidylinositol 4-Kinase Type IIα (PI4KIIα) as a potential target for drug discovery”. Patent number: ZL200810104272.

3. Yi Wan, Chang Chen, “Eliminating P. aeruginosa virulence based on NO inhibition of PCN”, No.PCT/CN20161102973

4. Chang Chen, Cheng Luo, Hualiang Jiang , Jiangmei Li, Zhen Gao, Dan Zhao, Lunfeng Zhang, Xinhua Qiao,The application of PI-273, the specific inhibitor of PI4KIIα,No.201510831539.6.

5. Yi Wan, Chang Chen, Lei Gao, Yuying Zhang, Xinhua Qiao, Yan Wang,“Eliminating P. aeruginosa virulence based on NO inhibition of PCN”, No. PCT/CN2016/102973

Book Chapters

1. Chang Chen, H. R. Tang, and P. Belton. Natural antioxidants - an ESR perspective, in "Magnetic Resonance in Food Science”, pp117-128, edited by G.A. Webb, published by the Royal Society of Chemistry, UK. 2000.

2. Chang Chen. Functions and the mechanism of nitric oxide. Invited chapter in: Free Radical Biology and Medicine, edited by R. L Zheng, Yixuan Publishers, Taiwan, 2013. ISBN 978-957-616-983-0.

  

 

From Chang Chen, 2017-02-20 update

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