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  Chang Chen, Ph.D, Prof.

  Professor, Principal Investigator at National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS).

  Distinguished Professor of CAS.

   Vice Director of National Laboratory of Biomacromolecules.

  Aging, Redox, Chinese traditional medicine 

  E-mail:changchen@moon.ibp.ac.cn,Tel:010-64888406

  Fax:010-6488406,Zip code:100101

  Chinese personal homepage  

Biography & Introduction

1986-1990  B.S.,  Nankai University, Tianjin, China

1990-1993  M.S.,  Beijing Normal University, Beijing, China

1993-1996  Ph.D.,  Peking University, Beijing, China

1996-1998  Assistant Professor, Institute of Biophysics, CAS

1998-2000  Associate Professor, Institute of Biophysics, CASVisiting Scientist in the Institute of Food Research, Norwich, UK (The Royal Society K.C. Wong Research Fellowship)

2000-Present  Principle Investigator (PI ) (2004, full professor. Institute of Biophysics, CAS.)

2004-2005  Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK

Professional activities

Vice Director of National Laboratory of Biomacromolecules

Professor of University of Chinese Academy of Sciences

Chief Scientist of “National Basic Research Program of China, 973 Program”

Chief Scientist of National Key R&D Program of China

Executive member of the council of The Biophysical Society of China

Council Member of The Chinese Society of Biochemistry and Molecular Biology

President of the Commission for Woman Scientists of the Biophysical Society of China

Council Member of the Chinese Society of Biochemistry and Molecular Biology

Vice Presidentof the Beijing Society of Biochemistry and Molecular Biology

Vice President of the Commission for Free Radical Biology and Medicine of the Biophysical Society of China

Council Member of International Society for Free Radical Research, -Asia

Editorial Board Member, Free Radical Biology & Medicine,Redox Biology,Free Radical Research

Associate Editor, Biophysics Reports,Progress in Biochemistry and Biophysics

Annual review of research grants, National Natural Science Foundation of China; International Collaboration Projects, National Basic Research Program of China

Awards and Honors

2015  Special Government Allowances of the State Council

2014  Outstanding Contribution, CAS-Beijing

2012  National Outstanding Young Scientists

2006  Young Scientist Award Society for Free Radical Research (SFRR)-Asia

Research Interest

        Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency result in impaired homeostasis and is associated with pathology, such as aging, cancer, atherosclerosis, neurodegenerative diseases, obesity, and diabetes. Our research has been focused on the crosstalk between these small molecules and macromolecules, trying to explore the relationship between protein function and cellular redox status. Based on it, try to find out effective approach to maintain cellular redox homeostasis and apply for good health. We are also interested in the working mechanism of traditional Chinese medicine (TCM) and its application.

The Ongoing Projects:

1. To explore Redox network - Redox map - Redox response: find out new redox genes, get the whole cell redox status map, illustrate the mechanism of redox regulation, particularly nitric oxide and S-nitros(yl)ation and other thiol modification in cellular quality control and physiopathology process.

2. To explore Redox stress and Aging: compare to the old Free radical theory of aging, we proposed that Redox-stress Response Capacity (RRC) is the key in aging process and it is under improvment. We are also interested in studying reductive stress and precision treatment in aging and aging related disease.

3. The working mechanism of traditional Chinese medicine (TCM) and its application, such as Goji (Lycium Barbarum) in aging.

4. Function, mechanism and the translational research of S-nitrosoglutathione reductase (GSNOR) and phosphatidylinositol 4-kinase type IIα (PI4KIIα).

Patents

1. Chang Chen, Bo Huang “A specific method for detection of thiol modification and its application”. Patent number: ZL200910084155.7.

2. Chang Chen, Jiangmei Li “The application of Phosphatidylinositol 4-Kinase Type IIα (PI4KIIα) as a potential target for drug discovery”. Patent number: ZL200810104272.

3. Yi Wan, Chang Chen, “Eliminating P. aeruginosa virulence based on NO inhibition of PCN”, No.PCT/CN20161102973

4. Chang Chen, Cheng Luo, Hualiang Jiang , Jiangmei Li, Zhen Gao, Dan Zhao, Lunfeng Zhang, Xinhua Qiao,The application of PI-273, the specific inhibitor of PI4KIIα,No.201510831539.6.

5. Yi Wan, Chang Chen, Lei Gao, Yuying Zhang, Xinhua Qiao, Yan Wang,“Eliminating P. aeruginosa virulence based on NO inhibition of PCN”, No. PCT/CN2016/102973

Book Chapters

1. Chang Chen, H. R. Tang, and P. Belton. Natural antioxidants - an ESR perspective, in "Magnetic Resonance in Food Science”, pp117-128, edited by G.A. Webb, published by the Royal Society of Chemistry, UK. 2000.

2. Chang Chen. Functions and the mechanism of nitric oxide. Invited chapter in: Free Radical Biology and Medicine, edited by R. L Zheng, Yixuan Publishers, Taiwan, 2013. ISBN 978-957-616-983-0.

Selected Publications (*as the corresponding author)

1. Zhang, L.F., Li, J. M., Zhang, P. P., Gao, Z., Zhao, Y.Y., Qiao, X.H. &Chen, C.* (2018). PI4KIIα Regulates Insulin Secretion and Glucose Homeostasis via a PKD-Dependent Pathway. Biophysics Reports. (Accepted)

2. Li, J.M., Gao, Z., Zhao, D., Zhang L.F., Qiao X.H., Zhao Y.Y., Ding, H., Zhang, P.P., Lu, J.Y., Liu, J., Jiang, H.L., Luo, C.* &Chen, C.*(2017). PI-273, a substrate-competitive, specific small molecule inhibitor of PI4KIIα, inhibits the growth of breast cancer cells. Cancer Research. 77(22):6253-6266.

3. Zhang,Y.Y., Wu, K.Y., Su W.T., Zhang D.F., Wang, P., Qiao, X.H.,, Yao, Q., Yuan,  Z.Q., Yao, Y.G., Liu, G.H., Zhang, C., Liu, L.M. &Chen, C.*(2017). Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKIIα. J. Neurosci.37(40):9741-9758.

4. Li, Y.Z., Zhang, Y.Y., Wang, L., Wang, P., Xue Y.H., Li X.P., Qiao, X.H., Zhang, Xu., Xu, T., Liu G.H., Li, P.&Chen,C.* (2017).Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia, Autophagy,13(7):1145-1160.

5. Ding, Y.Z., Li, Y.Z., Zhang, X., He, J.L., Lu, D., Fang, X., Wang, Y,C., Wang, J.X., Zhang, Y.Y., Qiao, X.H., Gan, L.M., Chen, C.*& Zhu, Y.*(2017). Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia–reperfusion injury. J Mol Cell Cardiol. 110:70-79.

6. Meng, J., Lv, Z.Y., Qiao, X.H., Li, X.P., Li, Y.Z. & Chen, C.* (2017). The decay of Redox-stress Adaptive Capacity is a substantive characteristic of aging: revising the redox theory of aging. Redox Bio.11,365-374.

7. Zhang, H., Yang, J., Si, W., Gong, W., Chen, C.* & Perrett, S.* (2016). Glutathionylation of DnaK provides a link between oxidative stress and the heat shock response. J. Biol. Chem. 291, 6967-6981.

8. Gao, L., Zhang, Y.Y., Wang Y., Qiao X.H., Zi, J., Chen, C.* & Wan, Y.* (2016) . Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa. Redox Bio. 8, 252–258.

9. Yin, R.Y., Fang, Li., Li, Y.J., Xue P., Li Y.Z., Guan Y.F., Chang Y.S., Chen, C.* & Wang, N.P.* (2015). Pro- inflammatory Macrophages suppress PPARγ activity in Adipocytes via S-nitrosylation. Free Radic. Biol. Med. 89, 895-905.

10. Qiao, X.H., HU, M.X., Zhang, Y.Y., Li Y.Z.& Chen, C.* (2015). Cellular redox regulation and thiol modification. Chinese Bulletin of Life Sciences 27(3), 374-382.

11. Zhou, Q.J., Li, J.M., Yu, H., Zhai, Y.J., Gao, Z., Liu, Y.X., Pang, X.Y., Zhang, L.F., Schulten, K*., Sun, F*. & Chen, C.* (2014).Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nat. Commun. 5, 35-52.

12. Li, J.M., Zhang, L.F., Gao, Z., Kang, H., Rong, G., & Chen, C.* (2014). Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα and EGFR as anti-tumor strategy. Protein & Cell 5(6), 457-468.

13. Wu, K., Ren, R., Su, W., Wen, B., Zhang, Y., Yi, F., Qiao, X., Yuan, T., Wang, J., Liu, L., Belmonte J.*, Liu, G*. & Chen, C.* (2014). A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J. Biol. Chem. 289, 20193-20199.

14. Wu, K., Zhang, Y., Wang, P., Zhang, L., Wang, T. & Chen, C.* (2014). Activation of GSNOR transcription by NF-kappaB negatively regulates NGF-induced PC12 differentiation. Free Radical Res. 48(9), 1011-1017.

15. Mao, K.R., Chen, S.Z., Chen, M.K., Ma, Y.L., Wang, Y., Huang, B., He, Z.Y., Zeng, Y., Hu, Y., Sun, S.H., Li, J., Wu, X.D., Wang, X.R., Strober, W., Chen, C.*, Meng, G.X.* & Sun. B. * (2013). Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res. 23, 201-212.

16. Zhang, X., Huang, B., Zhang, L., Zhang, Y.Y., Zhao, Y.Y., Guo, X.F., Qiao, X.H. & Chen, C.* (2012). SNObase, a database for S-nitrosation modification. Protein & Cell 3(12), 929-933.

17. Hou, Q.L., Jiang, H.Q., Zhang, X., Guo, C., Huang, B., Wang, P., Wang, T.P., Wu, K.K., Li, J., Gong, Z.F., Du, L.B., Liu, Y., Liu, L. & Chen, C.* (2011). Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila. Nitric Oxide-Bio. Chem. 24, 17-24.

18. Zhang, X., Huang, B., Zhou, X.X. & Chen, C.* (2010). Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method. Protein & Cell 1(7), 675-687.

19. Huang, B. & Chen, C.* (2010). Detection of protein S-Nitrosation using irreversible biotinylation procedures (IBP). Free Radic. Biol. Med. 49, 447-456.

20. Li, J.M., Lu, Y., Zhang, J.H., Kang, H., Qin, Z.H.* & Chen, C.* (2010). PI4KIIα is a novel regulator of tumor growth via its action on angiogenesis and HIF-1α regulation. Oncogene 29, 2550-2559.

21. Wang, P., Liu, G.H.* Wu, K.Y., Qu, J., Huang, B., Zhang, X., Zhou, X.X. & Chen, C.* (2009). Repression of classical nuclear export by S-nitrosylation of CRM1. J. Cell Sci. 20(122), 3772-3779.

22. Qu, J., Liu, G.H.* Wu, K.Y., Han, P.W., Wang, P., Li, J.M., Zhang, X.,& Chen, C.* (2007). Nitric oxide destabilizes pias3 and regulates sumoylation. PLoS One 2(10), e1085.

23. Qu, J., Liu, G.H., Huang, B. & Chen, C.* (2007). Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310. Nucleic Acids Research 8(35), 2522-2532.

24. He, J., Wang, T.P., Wang, P., Han, P.W.& Chen, C.* (2007). A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: the occurrence and regulation of protein S-nitrosylation is the checkpoint. J. Neurochem. 6(102): 1863-1874.

 

 

  

 

 

From Chang Chen, 2018-02-11 update

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