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Hongyu Deng, Ph.D, Prof.

Principal Investigator

Chinese Academy of Sciences Key Laboratory of Infection and Immunity,IBP

Replication mechanisms of viruses and virus-host interactions

E-mail:hydeng@moon.ibp.ac.cn, rrain6@yahoo.comTel:010-64888407

Fax:010-64888407,Zip code:100101

Chinese personal homepage

Biography & Introduction

1992-1997 Ph. D., University of Rochester, USA

1998-2002 Postdoctoral fellow, Albert Einstein College of Medicine & University of California at Los Angeles

2002-2004 Assistant Researcher & Assistant Professor, University of California at Los Angeles

2004-present Professor (Principle Investigator), Institute of Biophysics, Chinese Academy of Sciences

Dr. Deng has spent much of her career studying viruses that are causative agents for tumors. Her main research interests are to investigate the replication mechanisms of viruses and virus-host interactions, so as to gain insights into viral pathogenesis and to develop better therapeutics and diagnosis. Her current work are summarized as follows: 1) to study the mechanisms governing transcriptional regulation, genome replication, and virion morphogenesis and egress of tumor-associated herpesviruses; 2) to investigate the interactions between tumor-associated herpesviruses and the host innate and adaptive immune systems, both in vitro and in vivo; 3) to develop and test novel gene delivery vectors based on a murine herpesvirus; 4) to investigate the underlying mechanisms for viral hepatitis.

Selected Publications (*Corresponding author)

2016 

Jia X, Shen S, Lv Y, Zhang Z, Guo H, Deng H*. Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68. J Virol. 2016 Jul 27;90(16):7587-92. doi: 10.1128/JVI.03231-15. Print 2016 Aug 15.

2015 

Chen Y, He L, Shi X, Chen J, Zhong J, Chen X, Cheng G*, Deng H*. The hepatitis C virus protein NS3 suppresses TNF-a–stimulated activation of NF-kB by targeting LUBAC. Sci Signal. 2015 Nov 17;8(403): ra118. doi: 10.1126/scisignal.aab2159.

Qi J, Han C, Gong D, Liu P, Zhou S, and Deng H*. Murine gammaherpesvirus 68 ORF48 is an RTA responsive gene product and functions in both viral lytic replication and latency during in vivo infection. J Virol. 2015 Jun 1;89(11):5788-800. doi:10.1128/JVI.00406-15. Epub 2015 Mar 11. JVI Spotlight.

Shen S, Jia X, Guo H, and Deng H*. Gammaherpesvirus Tegument Protein ORF33 Is Associated with Intranuclear Capsids at an Early Stage of the Tegumentation Process. J Virol. 2015 May;89(10):5288-97. doi: 10.1128/JVI.00079-15. Epub 2015 Feb 25.

2014 

Chen Y, Wang S, Yi Z, Tian H, Aliyari S, Li Y, Chen G, Liu P, Zhong J, Chen X, Du P, Su L, Qin FX, Deng H*, Cheng G*. Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms. Sci Rep. 2014 Dec 3; 4:7242. doi: 10.1038/srep07242. Epub 2014 Dec 3.

Wong-Ho E, Wu TT, Davis ZH, Zhang B, Huang J, Gong H, Deng H, Liu F, Glaunsinger B, Sun R. Unconventional Sequence Requirement for Viral Late Gene Core Promoters of Murine Gammaherpesvirus 68. J Virol, 2014 Mar;88(6):3411-22. doi: 10.1128/JVI.01374-13. Epub 2014 Jan 8.

Shen S, Guo H, and Deng H*. Murine gammaherpesvirus-68 ORF38 encodes a tegument protein and is packaged into virions during secondary envelopment. Protein Cell. 2014 Feb;5(2):141-50.doi: 10.1007/s13238-013-0005-0. Epub 2014 Jan 29.

2013 

Duarte M, Wang L, Calderwood MA, Adelmant G, Ohashi M, Roecklein-Canfield J, Marto JA, Hill DE, Deng H, Johannsen E. An RS Motif within the Epstein-Barr Virus BLRF2 Tegument Protein Is Phosphorylated by SRPK2 and Is Important for Viral Replication. PLoS One. 2013;8(1):e53512. doi: 10.1371/journal.pone.0053512.Epub 2013 Jan 9.

Xuan Y, Gong D, Qi J, Han C, Deng H*, Gao G*. ZAP inhibits murine gammaherpesvirus-68 ORF64 expression and is antagonized by RTA. J Virol, 2013 Mar;87(5):2735-43.doi: 10.1128/JVI.03015-12. Epub 2012 Dec 19.

2012 

Xuan Y, Liu L, Shen S, Deng H*, Gao G*. Zinc-finger antiviral protein inhibits murine gammaherpesvirus-68 M2 expression and regulates viral latency in cultured cells. J Virol, 2012 Nov;86(22):12431-4.doi: 10.1128/JVI.01514-12. Epub 2012 Sep 5.

Sun Q, Han C, Liu L, Wang Y, Deng H, Bai L, Jiang T. Crystal structure and functional implication of the RUN domain of human NESCA. Protein Cell. 2012 Aug;3(8):609-17. doi: 10.1007/s13238-012-2052-3. Epub 2012 Jul 22.

Wang L, Guo H, Reyes N, Lee S, Bortz E, Guo F, Sun R, Tong L, Deng H*. Distinct Domains in ORF52 Tegument Protein Mediate Essential Functions in Murine Gammaherpesvirus 68 Virion Tegumentation and Secondary Envelopment. J Virol, 2012 Feb;86(3):1348-57. doi: 10.1128/JVI.05497-1. Epub 2011 Nov 16.

Noh CW, Cho HJ, Kang HR, Jin HY, Lee S, Deng H, Wu TT, Arumugaswami V, Sun R, Song MJ. The Virion-Associated Open Reading Frame 49 of Murine Gammaherpesvirus 68 Promotes Viral Replication both In Vitro and In Vivo as a Derepressor of RTA. J Virol. 2012 Jan;86(2):1109-18.doi: 10.1128/JVI.05785-1.Epub 2011 Nov 16.

2011 

Lee S, Salwinski L, Zhang C, Chu D, Sampankanpanich C, Reyes NA, Vangeloff A, Xing F, Li X, Wu T, Sahasrabudhe S, Deng H, LaCount DJ, Sun R. An Integrated Approach to Elucidate the Intra-Viral and Viral-Cellular Protein Interaction Networks of a Gamma-Herpesvirus. PLoS Pathog 7(10): e1002297. doi:10.1371/journal.ppat.1002297, 2011. Epub 2011 Oct 20.

Hong Y, Qi J, Gong D, Han C, Deng H*. Replication and Transcription Activator of Murine Gammaherpesvirus-68 Binds to An RTA-responsive Element and Activates the Expression of ORF18. J Virol, 2011 Nov;85(21):11338-50.doi: 10.1128/JVI.00561-11. Epub 2011 Aug 17.

Qi J, Gong D, and Deng H*. CCAAT/enhancer binding proteins play a role in oriLyt dependent genome replication during murine gammaherpesvirus 68 (MHV-68) de novo infection. Protein Cell, 2011 Jun; 2(6):463-9.doi: 10.1007/s13238-011-1060-z. Epub 2011 Jul 12.

Ding X, Yang W, Shi X, Du P, Su L, Qin Z, Chen J, Deng H*. Tumor Necrosis Factor Receptor 1 Mediates Dendritic Cell Maturation and CD8 T Cell Response through Two Distinct Mechanisms. J Immunol. 2011 Aug 1;187(3):1184-91. doi: 10.4049/jimmunol.1002902. Epub 2011 Jun 27.

Cao Y, Koh X, Dong L, Du X, Wu A, Ding X, Deng H, Shu Y, Chen J, Jiang T. Rapid Estimation of Binding Activity of Influenza Virus Hemagglutinin to Human and Avian Receptors. PLoS One 6(4): e18664. doi:10.1371/journal.pone.0018664.Epub 2011 Apr 13.

Hong Y, Qi J, Gong D, Deng J, Deng H*. Identification of an RTA Responsive Element in Murine Gammaherpesvirus-68 Genome. Progress in Biochemistry and Biophysics. 2011;38:936-944.

Yang W, Ding X, Deng J, Lu Y, Matsuda Z, Thiel A, Chen J, Deng H*, Qin Z*. Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection. J Mol Med. 2011 Apr;89(4):399-409. doi: 10.1007/s00109-010-0711-5. Epub 2010 Dec 30.

2010 

Guo H, Shen S, Wang L, Deng H*. Role of tegument proteins in herpesvirus assembly and egress. Protein Cell. 2010 Nov;1(11):987-98.doi: 10.1007/s13238-010-0120-0. Epub 2010 Dec 10.(Invited review)

Li X, Chen S, Feng J, Deng H, Sun R. Myc Is Required for the Maintenance of Kaposi's Sarcoma-Associated Herpesvirus Latency. J Virol. 2010 Sep;84(17):8945-8. doi: 10.1128/JVI.00244-10. Epub 2010 Jun 23.

Li X, Feng J, Chen S, Peng L, He WW, Qi J, Deng H, Sun R. Tpl2/AP-1 Enhances Murine Gammaherpesvirus 68 Lytic Replication. J Virol. 2010 Feb;84(4):1881-90. doi: 10.1128/JVI.01856-09. Epub 2009 Nov 25.

Peng L, Wu TT, Tchieu JH, Feng J, Brown HJ, Feng J, Li X, Qi J, Deng H, Vivanco I, Mellinghoff IK, Jamieson C, Sun R. The Inhibition of PI3K-Akt Pathway Enhances Gamma-2 Herpesvirus Lytic Replication and Facilitates Reactivation from Latency. J Gen Virol. Feb;91(Pt 2):463-9, 2010. doi: 10.1099/vir.0.015073-0. Epub2009 Oct 28.

2009 

Guo H., Wang LL, Peng L., Zhou ZH, and Deng H*. ORF33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress. J Virol. Oct;83(20):10582-95, 2009. doi: 10.1128/JVI.00497-09. Epub 2009 Aug 5.

Xu X, Lou Z, Ma Y, Chen X, Yang Z, Tong X, Zhao Q, Xu Y, Deng H, Bartlam M, and Rao Z. Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. PLoS One 4(7):e6217, 2009. doi: 10.1371/journal.pone.0006217. Epub 2009 Jul 10.

Liao HI, Olson CA, Hwang S, Deng H, Wong E, Baric RS, Roberts RW, Sun R. mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein. J Biol Chem. 2009 Jun 26;284(26):17512-20. doi: 10.1074/jbc.M901547200. Epub 2009 Apr13.

Gong D, Qi J, Arumugaswami V, Sun R, Deng H*. Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus-68. Virology. 2009 May 10; 387(2):285-95. doi: 10.1016/j.virol.2009.02.029. Epub 2009 Mar 12.

Yang Z, Tang H, Huang H, Deng H*. RTA promoter demethylation and histone acetylation regulation ofmurine gammaherpesvirus 68 reactivation. PloS One 4(2):e4556, 2009.doi:10.1371/journal.pone.0004556.Epub 2009 Feb 23. (Recommended by “Faculty of 1000 Biology”:http://www.f1000biology.com/article/id/1157092/evaluation)

Di Bartolo DL, Hyjek E, Keller S, Guasparri I, Deng H, Sun R, Chadburn A, Knowles DM, Cesarman E. Role of defective Oct-2 and OCA-B expression in immunoglobulin production and KSHV lytic reactivation in primary effusion lymphoma. J Virol. 83: 4308-15, 2009.doi: 10.1128/JVI.02196-08.Epub 2009 Feb 18.

Wu TT, Park T, Kim H, Tran T, Tong L, Martinez-Guzman D, Reyes N, Deng H, Sun R. ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68. J Virol. 83:2265-73,2009.doi: 10.1128/JVI.01785-08. Epub 2008 Dec 17.

Arumugaswami V, Sitapara R, Hwang S, Song MJ, Ho TN, Su NQ, Sue EY, Kanagavel V, Xing F, Zhang X, Zhao M, Deng H, Wu TT, Kanagavel S, Zhang L, Dandekar S, Papp J, Sun R. High-resolution Functional Profiling of a Gammaherpesvirus RTA Locus in the Context of the Viral Genome. J Virol. 83:1811-22, 2009.doi: 10.1128/JVI.02302-08. Epub 2008 Dec 10.

2009年前代表性论文 

Lee S, Deng H*, Yu F, Melega WP, Damoiseaux R, Bradley KA, Sun R. Regulation of KSHV Reactivation by Dopamine Receptor-Mediated Signaling Pathways. J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):531-40. doi: 10.1097/QAI.0b013e31817fbdcf. (*Co-Correspondingauthors)

Benach J, Wang L, Chen Y, Ho CK, Lee S, Seetharaman J, Xiao R, Acton TB, Montelione GT, Deng H, Sun R, Tong L. Structural and functional studies of the abundant tegument proteinORF52 frommurine gammaherpesvirus-68. J Biol Chem. 2007 Oct 26;282(43):31534-41. Epub 2007 Aug 15.

Bortz E, Wang L, Jia Q, Wu TT, Whitelegge JP, Deng H, Zhou ZH, Sun R. Murine Gammaherpesvirus-68 ORF52 Encodes a Tegument Protein Required for Virion Morphogenesis in the Cytoplasm. J Virol. 2007 Sep;81(18):10137-50. Epub 2007 Jul 18.

Wong E, Wu TT, Reyes N, Deng H, Sun R. Murine gammaherpesvirus 68 open reading frame 24 is required for late gene expression after DNA replication. J Virol. 2007 Jun;81(12):6761-4. Epub 2007 Mar 28.

Yu F, Harada JN, Brown HJ, Deng H, Song MJ, Wu TT, Kato-Stankiewicz J, Nelson CG, Vieira J, Tamanoi F, Chanda SK, Sun R. Systematic identification of cellular signals reactivating Kaposi’sarcoma-associated herpesvirus. PLoS Pathog. 2007 Mar;3(3):e44.doi:10.1371/journal.ppat.0030044. Epub 2007 Mar 30.

Deng H, Liang Y, Sun R. Regulation of KSHV lytic gene expression. Curr Top Microbiol Immunol. 2007;312:157-83. (Invited review)

Arumugaswami V, Wu TT, Martinez-Guzman D, Jia Q, Deng H, Reyes N, Sun R. ORF18 is a transfactor that is essential for late gene transcription of a gammaherpesvirus. J Virol. 2006 Oct;80(19):9730-40.doi: 10.1128/JVI.00246-06

Chang M, HJ Brown, TL Symensma, L. Tanaka, JM Arevalo, A. Collado-Hidalgo, Z. Galic, Deng H, JA Zack, R. Sun, and SW Cole. Activation of HHV-8 lytic replication by -adrenoreceptors: PKA-dependent control of RTA expression and trans-activating capacity. J Virol. 2005 Nov; 79(21): 13538-47.doi: 10.1128/JVI.79.21.13538-13547.2005

Rickabaugh TM, Brown HJ, Wu TT, Song MJ, Hwang S, Deng H, Mitsouras K, Sun R. Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8 reactivates murine gammaherpesvirus 68 from latency. J Virol. 2005 Mar;79(5):3217-22.doi: 10.1128/JVI.79.5.3217-3222.

Deng H*, Chu JT, Park NH, Sun R. Identification of cis-sequences required for lytic replication and packaging of murine gammaherpesvirus-68. J Virol. 2004 Sep;78(17):9123-31. (*Corresponding author)

Zhu J, Trang P, Kim K, Zhou T, Deng H, Liu F. Effective inhibition of Rta expression and lytic replication of Kaposi’s sarcoma-associated herpesvirus by human RNase P. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9073-8. Epub 2004 Jun 7.

Song MJ, Deng H, Sun R. Sun. Comparative study of regulation of RTA-responsive genes in Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8. J Virol. 2003 Sep;77(17):9451-62.

Brown HJ, Song MJ, Deng H, Wu TT, Cheng G, and Sun R. Gammaherpesviruses replication is regulated by NF-kappaB. J Virol. 2003 77:8532-8540.

Deng H, Song MJ, Chu JT, Sun R. Transcriptional regulation of the interleukin-6 gene encoded by human herpesvirus 8/Kaposi’s sarcoma-associated herpesvirus. J Virol. 2002 Aug;76(16):8252-64.

Deng H, Chu JT, Rettig MB, Martinez-Maza O, Sun R. Rta of the human herpesvirus 8/Kaposi’s sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. Blood. 2002 Sep 1;100(5):1919-21.

Varthakavi V, Smith RM, Deng H, Sun R, Spearman P. Human Immunodeficiency Virus Type-1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus through Induction of KSHV Rta. Virology. 2002 Jun 5;297(2):270-80.

Deng H, Young A, Sun R. Auto-activation of the rta gene of human herpesvirus 8/Kaposi’s sarcoma-associated herpesvirus. J Gen Virol. 2000 Dec;81(Pt 12):3043-8.

Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA. Telomerase reverse transcriptase is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene. 1999 Feb 4;18(5):1219-26.

Deng H, Dewhurst S. Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6. J Virol. 1998 Jan;72(1):320-9.

Bulboaca, GH, Deng H, Dewhurst S. and Calos MP. Telomeric sequences from human herpesvirus 6 do not mediate nuclear retention of episomal DNA in human cells. Arch Virol. 1998;143(3):563-70.

van Loon N, Dykes C, Deng H, Dominguez G, Nicholas J, Dewhurst S. Identification and analysis of a lytic phase origin of DNA replication in human herpesvirus 7. J Virol. 1997 Apr;71(4):3279-84.

Secchiero P, Nicholas J, Deng H, Xiaopeng T, van Loon N, Ruvolo VR, Berneman ZN, Reitz MS Jr, Dewhurst S. Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity. J Virol. 1995 Dec;69(12):8041-5.

 

From Hongyu Deng, 2017-01-01 update

 

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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
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