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Runsheng Chen, Prof., CASM

Principal Investigator
Director of Academic Board
Key Laboratory of RNA Biology, Institute of Biophysics, CAS
Expertise: Theoretical biology, Bioinformatics, Noncoding RNA
E-mail:chenrs@sun5.ibp.ac.cn,Tel:86-10-64888543
Fax:86-10-64871293,Zip code:100101

Biography & Introduction

1964: Graduated from Department of Biophysics, University of Science and Technology of China (USTC)

1978-1980: Postgraduate: Institute of Theoretical Chemistry, Jilin University

1985.6-1987.8: Institute for Theoretical Chemistry, University Erlangen-Nurnberg, FRG, as a Fellow of Alexander von Humboldt Foundation

1994-2003: Dept. of Statistics, the Chinese University of Hong Kong; Interdivisional Program in Statistics, the University of California at Los Angeles (UCLA); Department of Biostatistics, Harvard University; Institute of Protein Research, Osaka University, Japan; National Center for Theoretical Sciences, Taiwan; as a Visiting Scholar or Visiting Professor

1989-present: Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences

2007: elected as an Academician of the Chinese Academy of Sciences

2014: elected as an Academician of theInternationaI Academy of Sciences for Europe and Asia

Currently, Prof. Chen serves as a member of Human Genome Organization (HUGO), a member of the biomacromolecule group of The Committee on Data for Science and Technology (CODATA), and a member of the bioinformatics professional committee of the International Union of Pure and Applied Physics (IUPAP). In addition, Prof. Chen is the General-secretary and Vice president of Chinese Society of Biophysics.

Professor Runsheng Chen is one of the pioneer scholars developing the researches on theoretical biology, bioinformaticsand noncoding RNA in China. For more than twenty years, Prof. Chen has led his group to perform a series of systemic researches in the field of bioinformatics, including the whole genome assembly and annotation for T. tengcongensis B4 (the first bacterium genome completely sequenced in China), the 1% Human Genome Project, and the Draft Sequence of the Rice Genome. Since 2001, Prof. Chen has rapidly expanded his interest to the investigation of noncoding RNAs, two widely used noncoding RNA databases (NONCODE, http://www.noncode.org/ and NPInter, http://www.bioinfo.org/NPInter/) have been established and updated periodically. So far, Prof. Chen has published more than 200 papers in SCI, and made more than 20 conference or group reports in the international academic conferences since 1996. For his outstanding early studies on genomic informatics, Prof. Chen was invited to give the "Kotani Memorial Lecture" on the 15th International CODATA Conference, Tsukuba, Japan, 29 Sep. - Oct. 1996, and then selected as the winner of "Kotani Prize". Recently, Prof. Chen was granted the Prize for Scientific and Technological Progress of Ho Leung Ho Lee Foundation in 2008, Tan Jiazhen life sciences and Achievement Award in 2012, and second-class prize of national science and Technology Progress Award in 2013.

Selected Publications

[1] Chen X, Hao Y, Cui Y, Fan Z, He S, Luo J and Chen R. LncVar: a database of genetic variation associated with long non-coding genes. Bioinformatics 2017; 33: 112-118.

[2] Zhao Y, Li H, Fang S, Kang Y, Wu W, HaoY, . . . Chen R. NONCODE 2016: an informative and valuable data source of long non-coding RNAs. Nucleic Acids Res 2016; 44: D203-208.

[3] Liu L, Yue H, Liu Q, Yuan J, Li J, Wei G, . . . Chen R. LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway. Oncotarget 2016; 7: 15787-15800.

[4] Cui Y, Chen X, Luo H, Fan Z, Luo J, He S, . . . Chen R. BioCircos.js: an interactive Circos JavaScript library for biological data visualization on web applications. Bioinformatics 2016; 32: 1740-1742.

[5] Xiao T, Liu L, Li H, Sun Y, Luo H, Li T, . . . Chen R. Long Noncoding RNA ADINR Regulates Adipogenesis by Transcriptionally Activating C/EBPalpha. Stem Cell Reports 2015; 5: 856-865.

[6] Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, . . Chen R, Fan Z. The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling. Cell Stem Cell 2015; 16: 413-425.

[7] Yuan J, Wu W, Xie C, Zhao G, Zhao Y and Chen R. NPInter v2.0: an updated database of ncRNA interactions. Nucleic Acids Res 2014; 42: D104-108.

[8] Li J, Chen Z, Tian L, Zhou C, He MY, Gao Y, . . . Chen R, He J. LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma. Gut 2014; 63: 1700-1710.

[9] Lu X, Wang L, Chen S, He L, Yang X, Shi Y, . . . Chen R, . Coronary ADG-WR. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nature Genetics 2012; 44: 890-+.

[10] Wang Y, Chen J, Wei G, He H, Zhu X, Xiao T, . . . Chen R. The Caenorhabditiselegans intermediate-size transcriptome shows high degree of stage-specific expression. Nucleic Acids Research 2011; 39: 5203-5214.

[11] Zhao Y, He S, Liu C, Ru S, Zha H, Yang Z, . . . Chen R. MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control. Trends in Genetics 2008; 24: 323-327.

[12] He S, Su H, Liu C, Skogerbo G, He H, He D, . . . Chen R. MicroRNA-encoding long non-coding RNAs. BMC Genomics 2008; 9:

[13] Aftab MN, He H, Skogerbo G and Chen R. Microarray analysis of ncRNA expression patterns in Caenorhabditiselegans after RNAi against snoRNA associated proteins. BMC Genomics 2008; 9: 278.

[14] He H, Wang J, Liu T, Liu XS, Li T, Wang Y, . . . Chen R. Mapping the C-elegans noncoding transcriptome with a whole-genome tiling microarray. Genome Research 2007; 17: 1471-1477.

[15] Zhang Z, Liu C, Skogerbo G, Zhu X, Lu H, Chen L, . . . Chen R. Dynamic changes in subgraph preference profiles of crucial transcription factors. Plos Computational Biology 2006; 2: 383-391.

[16] Zhang Y, Li S, Skogerbo G, Zhang Z, Zhu X, Zhang Z, . . . Chen R. Phylophenetic properties of metabolic pathway topologies as revealed by global analysis. BMC Bioinformatics 2006; 7:

[17] Muzny D, Scherer S, Kaul R, Wang J, Yu J, Sudbrak R, . . . Chen R, … Gibbs R. The DNA sequence, annotation and analysis of human chromosome 3. Nature 2006; 440: 1194-1198.

[18] He H, Cai L, Skogerbo G, Deng W, Liu T, Zhu X, . . . Chen R. Profiling Caenorhabditiselegans non-coding RNA expression with a combined microarray. Nucleic Acids Research 2006; 34: 2976-2983.

[19] Deng W, Zhu X, Skogerbo G, Zhao Y, Fu Z, Wang Y, . . . Chen R. Organization of the Caenorhabditiselegans small non-coding transcriptome: Genomic features, biogenesis, and expression. Genome Research 2006; 16: 20-29.

[20] Liu C, Bai B, Skogerbo G, Cai L, Deng W, Zhang Y, . . . Chen R. NONCODE: an integrated knowledge database of non-coding RNAs. Nucleic Acids Research 2005; 33: D112-D115.

[21] Yu J, Hu S, Wang J, Wong G, Li S, Liu B, . . . Chen R, … Yang H. A draft sequence of the rice genome (Oryza sativa L. sspindica). Science 2002; 296: 79-92.

[22] Bu D, Zhao Y, Cai L, Xue H, Zhu X, Lu H, . . . Chen R. Topological structure analysis of the protein-protein interaction network in budding yeast. Nucleic Acids Res 2003; 31: 2443-2450.

[23] Bao Q, Tian Y, Li W, Xu Z, Xuan Z, Hu S, . . . Chen R, .. Yang H.A complete sequence of the T tengcongensis genome. Genome Research 2002; 12: 689-700.

[24] Li W, Fang W, Ling L, Wang J, Xuan Z and Chen R. Phylogeny Based on Whole Genome as inferred from Complete Information Set Analysis. Journal of Biological Physics 2002; 28: 439-447.

 

From Runsheng Chen, 2017-01-09 update

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