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  Dong Li, Ph.D, Prof.

  Principal Investigator

  National Laboratory of Biomarcomolecules, Institute of Biophysics

  Optical imaging techniques development and application

  Email: lidong@ibp.ac.cn

  Chinese personal homepage

Biography & Introductions

Education & Research Experience

2002-2006, B.E., Department of Optical Engineering, Zhejiang University

2006-2011, Ph.D., Department of Electronic & Computer Engineering, Hong Kong University of Science & Technology

2011-2015, Postdoctoral Associate, Janelia Research Campus, Howard Hughes Medical Institute

2015-, Professor, Institute of Biophysics, Chinese Academy of Science

Academic Awards

2017, Thousand Young Talents program of China

2015, PicoQuant Young Investigator Award, SPIE

2011, Winner of Young Scientist Award, Hong Kong Institute of Science

Research Interests

We focus on developing novel optical imaging methods, which enable us to measure and study the biological processes with unprecedented precision, such as structures and dynamics of molecular assemblies in living biological systems, interactions between molecules, and behavior of individual molecules, etc. We are greatly enjoying working at the interface of several disciplines, where light, biology and chemistry catalyze each other.

Selected Publications

1. Y.Guo#, D. Li#, S. Zhang, Y. Yang, J-J. Liu, X. Wang, C. Liu, D.E. Milkie, R.P. Moore, U.S. Tulu, D.P. Kiehart, J. Hu, J. Lippincott-Schwartz*, E.Betzig*, D Li*. Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales, Cell, 2018, V.175, 1430-1442 (2018).

2. X. Han, P. Li, Z. Yang, X. Huang, G. Wei, Y. Sun, X. Kang, X. Hu, Q. Deng, L. Chen, A. He, Y. Huo, D. Li*, E. Betzig, & J. Cai*, “Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules”, Nature Communications, V. 8, 14639 (2017).

3. D. Li, L. Shao, B-C. Chen, X. Zhang, M. Zhang, B. Moses, D. E. Milkie, J.R. Beach, J. A. Hammer, M. Pasham, T. Kirchhausen, M. A. Baird, M. W. Davidson, P. Y. Xu, & E. Betzig, “Extended resolution structured illumination imaging of endocytic and cytoskeletal dynamics”, Science, V.349, 6251 (2015). Cover article, highlighted by AAAS, MIT Technology Review, Faculty of 1000, Photonics, HHMI News, etc.

4. N. Billington, J. R. Beach, S. M. Heissler, K. Remmert, S. Guzik-Lendrum, A. Nagy, Y. Takagi, L. Shao, D. Li, Y. Yang, Y. Zhang, M. Barzik, E. Betzig, J. A. Hammer, J. R. Sellers, “Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments”, Current Biology, V.25, 942-948 (2015).

5. J. R. Beach, L. Shao, K. Remmert, D. Li, E. Betzig, & J. A. Hammer, “Nonmuscle myosin II isoforms coassemble in living cells”, Current Biology, V.24, 1160-1166 (2014). Highlighted by Faculty of 1000

6. D. Li, W. Zheng, Y. Zeng, Y. Luo, & J. Y. Qu, "Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo", Optics Letters, V.36, 834-836 (2011).

7. D. Li, W. Zheng, W. Zhang, S. K. Teh, Y. Zeng, Y. Luo, & J. Y. Qu, "Time-resolved detection enables standard two-photon fluorescence microscope for in vivo label-free imaging of microvasculature in tissue", Optics Letters, V.36, 2638-2640 (2011). Editor highlighted article

8. D. Li, W. Zheng, Y. Zeng, & J. Y. Qu, "In vivo and simultaneous multimodal imaging: integrated multiplex CARS and two-photon microscopy", Applied Physics Letters, V.97, 223702 (2010).

9. D. Li, W. Zheng, & J. Y. Qu, "Imaging of epithelial tissue in vivo based on excitation of multiple endogenous nonlinear optical signals", Optics Letters, V.34, 2853-2855 (2009).

10. D. Li, W. Zheng, & J. Y. Qu, "Two-photon autofluorescence microscopy of multicolor excitation", Optics Letters, V.34, 202-204 (2009).

11. D. Li, W. Zheng, & J. Y. Qu, "Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence", Optics Letters, V.33, 2365-2367 (2008).

 

From Dong Li,2019-03-06 update

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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
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