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Zhihai Qin, Ph.D, Prof.

Principal Investigator
Key Laboratory of Protein and Peptide Drugs,IBP
Tumor microenvironment and tumor immunity
E-mail:zhihai@ibp.ac.cn,Tel:010-64888570
Fax:010-64871293,Zip code:100101

Biography & Introduction

1992: M.D., Free University of Berlin, Germany;

1992-1994: Post-Doc fellow, Fox Chase Cancer Center, Philadelphia, U.S.A.;

1994-2000: Senior research fellow, MDC for Molecular Medicine, Berlin;

2000-2005: Research project leader, Institute of Immunology, FU Berlin, Germany;

2005-: Principle investigator, "Hundred Talent" Program of CAS, Institute of Biophysics Chinese Academy of Sciences, Beijing

The pro-inflammatory cytokine-mediated stroma cell interactions exert both beneficial and adverse effects on tumor progression. The finding of key regulatory molecules and understanding of corresponding mechanisms help to develop novel strategies for tackling cancer by modifying stroma cell interactions.

- Non-hematopoietic cells are important immune effector cells. Our results showed that responsiveness of stroma fibroblasts to IFNg blocks tumor growth via angiostasis, which reveals a novel link between immune cells and non-bone marrow-derived stroma cells, and de?nes stroma ?broblasts as the main targets of IFNg in tumor immunity.

- Stroma fibroblast-mediated foreign body reaction acts as an important way to prevent tumorigenesis. The depletion of fibroblasts demonstrated that fibroblasts play an indispensable role in preventing epithelial malignancy by the collagen deposition around carcinogen and provide a novel mechanism for host surveillance against cancer.

- Tumor stroma cell interactions influence tumor development. Our results demonstrate that tumor stroma is not only bystanders during tumor development. The interaction between different pro-inflammatory cytokines and between cytokines and stromal cells could promote or inhibit tumor development. It is of great important to understand these interactions and make use of it to attack tumor.

Selected publications: (*corresponding author)

1) Ji T, Lang J, Wang J, Cai R, Zhang Y, Qi F, Zhang L, Zhao X, Wu W, Hao J, Qin Z*, Zhao Y*, Nie G*. 2017. Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy. ACS Nano, 11(9):8668-8678.

2) Ni C, Ma P, Qu L, Wu F, Hao J, Wang R, Lu Y, Yang W, Erben U, Qin Z*. 2017. Accelerated tumour metastasis due to interferon-gamma receptor-mediated dissociation of perivascular cells from blood vessels. J Pathol, 242(3):334-346.

3) Deng H, Song K, Zhao X, Li Y, Wang F, Zhang J, Dong A, Qin Z*. 2017. Tumor Microenvironment Activated Membrane Fusogenic Liposome with Speedy Antibody and Doxorubicin Delivery for Synergistic Treatment of Metastatic Tumors. ACS Appl Mater Interfaces, 9(11):9315-9326.

4) Xu X, Meng Q, Erben U, Wang P, Glauben R, Kuhl AA, Wu H, Ma CW, Hu M, Wang Y,  Sun W, Jia J, Wu X, Chen W, Siegmund B, Qin Z*. 2017. Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner. Cell Mol Immunol, 14(7):597-606.

5) Shao W, Zhang C, Liu E, Zhang L, Ma J, Zhu Z, Gong X, Qin Z*, Qiu X*. 2016. Identification of Liver Epithelial Cell-derived Ig Expression in mu chain-deficient mice. Sci Rep 6: 23669

6) Atretkhany KS, Nosenko MA, Gogoleva VS, Zvartsev RV, Qin Z, Nedospasov SA, Drutskaya MS*. 2016. TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC Accumulation. Front Immunol 7: 147

7) Xu X, Meng Q, Erben U, Wang P, Glauben R, Kuhl AA, Wu H, Ma CW, Hu M, Wang Y, Sun W, Jia J, Wu X, Chen W, Siegmund B, Qin Z*. 2016. Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner. Cell Mol Immunol.

8) Chen L, Li J, Wang F, Dai C, Wu F, Liu X, Li T, Glauben R, Zhang Y, Nie G, He Y*, Qin Z*. 2016. Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy. Cancer Res

9) Ji T, Zhao Y, Ding Y, Wang J, Zhao R, Lang J, Qin H, Liu X, Shi J, Tao N, Qin Z, Nie G*. 2016. Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation. Angew Chem Int Ed Engl. 55(3): 1050–1055.

10) Sun L, Sun C, Liang Z, Li H, Chen L, Luo H, Zhang H, Ding P, Sun X, Qin Z*, Zhao Y*. 2015. FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Sci Rep 5: 14871

11) Yang S, Wang Y, Mei K, Zhang S, Sun X, Ren F, Liu S, Yang Z, Wang X, Qin Z, Chang Z*. 2015. Tumor necrosis factor receptor 2 (TNFR2).interleukin-17 receptor D (IL-17RD) heteromerization reveals a novel mechanism for NF-kappaB activation. J Biol Chem 290: 861-71

12) Xu M, Liu M, Du X, Li S, Li H, Li X, Li Y, Wang Y, Qin Z, Fu YX*, Wang S*. 2015. Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype. J Immunol 194: 4997-5006

13) Zhang J*, Ni C, Yang Z, Piontek A, Chen H, Wang S, Fan Y, Qin Z, Piontek J. 2015. Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier. Exp Dermatol 24: 605-10

14) Ji T, Ding Y, Zhao Y, Wang J, Qin H, Liu X, Lang J, Zhao R, Zhang Y, Shi J, Tao N, Qin Z*, Nie G*. 2015. Peptide assembly integration of fibroblast-targeting and cell-penetration features for enhanced antitumor drug delivery. Adv Mater 27: 1865-73

15) Chen L, Li J, Zhang J, Dai C, Liu X, Wang J, Gao Z, Guo H, Wang R, Lu S, Wang F, Zhang H, Chen H, Fan X, Wang S, Qin Z*. 2015. S100A4 promotes liver fibrosis via activation of hepatic stellate cells. J Hepatol 62: 156-64

16) Xing S, Luo Y, Liu Z, Bu P, Duan H, Liu D, Wang P, Yang J, Song L, Feng J, Yang D, Qin Z, Yan X*. 2014. Targeting endothelial CD146 attenuates colitis and prevents colitis-associated carcinogenesis. Am J Pathol 184: 1604-16

17) Ni C, Wang C, Zhang J, Qu L, Liu X, Lu Y, Yang W, Deng J, Lorenz D, Gao P, Meng Q, Yan X, Blasig IE, Qin Z*. 2014. Interferon-gamma Safeguards Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis. Am J Pathol 184: 3308-20

18) Hu X, Li B, Li X, Zhao X, Wan L, Lin G, Yu M, Wang J, Jiang X, Feng W, Qin Z, Yin B*, Li Z*. 2014. Transmembrane TNF-alpha promotes suppressive activities of myeloid-derived suppressor cells via TNFR2. J Immunol 192: 1320-31

19) Gao P, Tao N, Ma Q, Fan WX, Ni C, Wang H, Qin ZH*. 2014. DH332, a synthetic beta-carboline alkaloid, inhibits B cell lymphoma growth by activation of the caspase family. Asian Pac J Cancer Prev 15: 3901-6

20) Deng J, Liu X, Rong L, Ni C, Li X, Yang W, Lu Y, Yan X, Qin C, Zhang L, Qin Z*. 2014. IFNgamma-responsiveness of endothelial cells leads to efficient angiostasis in tumours involving down-regulation of Dll4. J Pathol 233: 170-82

21) Zhang J, Chen L, Liu X, Kammertoens T, Blankenstein T, Qin Z*. 2013. Fibroblast-Specific Protein 1/S100A4-Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens. Cancer Res 73: 2770-81

22) Zhang G, Liu X, Wang C, Qu L, Deng J, Wang H, Qin Z*. 2013. Resolution of PMA-induced skin inflammation involves interaction of IFN-gamma and ALOX15. Mediators Inflamm 2013: 930124

23) Wang J, Wang X, Gao C, Song X, Niu Z, Gao Z, Qin Z, Chang J*, Wang H*. 2013. The pyrimidine analog FNC inhibits cell proliferation and viral protein synthesis in HTLV1infected cells. Mol Med Rep 7: 1656-60

24) Wang J, Niu Z, Shi Y, Gao C, Wang X, Han J, Li J, Gao Z, Zhu X, Song X, Qin Z*, Wang H*. 2013. Bcl-3, induced by Tax and HTLV-1, inhibits NF-kappaB activation and promotes autophagy. Cell Signal 25: 2797-804

25) Wang C, Xiao M, Liu X, Ni C, Liu J, Erben U, Qin Z*. 2013. IFN-gamma-mediated downregulation of LXA4 is necessary for the maintenance of nonresolving inflammation and papilloma persistence. Cancer Res 73: 1742-51

26) Rothe M, Quarcoo D, Chashchina AA, Bozrova SV, Qin Z, Nedospasov SA, Blankenstein T, Kammertoens T*, Drutskaya MS. 2013. IL-13 but not IL-4 signaling via IL-4Ralpha protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis. Cancer Med 2: 815-25

27) Deng J, Zhao X, Rong L, Li X, Liu X, Qin Z*. 2013. TNFR-1 on tumor cells contributes to the sensitivity of fibrosarcoma to chemotherapy. Protein Cell 4: 393-401

28) Zhao X, Rong L, Li X, Liu X, Deng J, Wu H, Xu X, Erben U, Wu P, Syrbe U, Sieper J, Qin Z*. 2012. TNF signaling drives myeloid-derived suppressor cell accumulation. J Clin Invest 122: 4094-104

29) Wu H, Tao N, Liu X, Li X, Tang J, Ma C, Xu X, Shao H, Hou B, Wang H, Qin Z*. 2012. Polysaccharide from Lentinus edodes inhibits the immunosuppressive function of myeloid-derived suppressor cells. PLoS One 7: e51751

30) Li J, Chen L, Qin Z*. 2012. Multifaceted tumor stromal fibroblasts. Cancer Microenviron 5: 187-93

31) Kammertoens T, Qin Z, Briesemeister D, Bendelac A, Blankenstein T*. 2012. B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-alpha, perforin). Int J Cancer 131: 1499-508

32) Zhang J, Chen L, Xiao M, Wang C, Qin Z*. 2011. FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. Am J Pathol 178: 382-90

33) Yang W, Ding X, Deng J, Lu Y, Matsuda Z, Thiel A, Chen J, Deng H, Qin Z*. 2011. Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection. J Mol Med (Berl) 89: 399-409

34) Lv J, Tao N, Wu H, Liu X, Xu X, Xu Y, Qin Z*. 2011. Selective expansion and enhanced anti-tumor effect of antigen-specific CD4(+) T cells by retrovirus-mediated IL-15 expression. Protein Cell 2: 585-99

35) Liu S, Rong L, Deng J, Zhao X, Liu X, Xu X, Qin Z*. 2011. TNFR2 expression on non-bone marrow-derived cells is crucial for lipopolysaccharide-induced septic shock and downregulation of soluble TNFR2 level in serum. Cell Mol Immunol 8: 164-71

36) Ding X, Yang W, Shi X, Du P, Su L, Qin Z*, Chen J*, Deng H*. 2011. TNF receptor 1 mediates dendritic cell maturation and CD8 T cell response through two distinct mechanisms. J Immunol 187: 1184-91

37) Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z*. 2011. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell 147: 436-46

38) Wang Z, Jiang J, Li Z, Zhang J, Wang H, Qin Z*. 2010. A myeloid cell population induced by Freund adjuvant suppresses T-cell-mediated antitumor immunity. J Immunother 33: 167-77

39) Li J, Lu Y, Zhang J, Kang H, Qin Z*, Chen C. 2010. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. Oncogene 29: 2550-9

40) Jiang J, Wang Z, Li Z, Zhang J, Wang C, Xu X, Qin Z*. 2010. Early exposure of high-dose interleukin-4 to tumor stroma reverses myeloid cell-mediated T-cell suppression. Gene Ther 17: 991-9

41) He XH, Zang Y, Chen X, Pang RP, Xu JT, Zhou X, Wei XH, Li YY, Xin WJ, Qin ZH, Liu XG*. 2010. TNF-alpha contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury. Pain 151: 266-79

42) Xiao M, Wang C, Zhang J, Li Z, Zhao X, Qin Z*. 2009. IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation. Cancer Res 69: 2010-7

43) Lu Y, Yang W, Qin C, Zhang L, Deng J, Liu S, Qin Z*. 2009. Responsiveness of stromal fibroblasts to IFN-gamma blocks tumor growth via angiostasis. J Immunol 183: 6413-21

44) Li Z, Chen L, Qin Z*. 2009. Paradoxical roles of IL-4 in tumor immunity. Cell Mol Immunol 6: 415-22

45) Li Z, Jiang J, Wang Z, Zhang J, Xiao M, Wang C, Lu Y, Qin Z*. 2008. Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. Cancer Res 68: 8687-94

46) Kuprash DV*, Qin Z, Ito D, Grivennikov SI, Abe K, Drutskaya LN, Blankenstein T, Nedospasov SA. 2008. Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice. Cancer Lett 268: 70-5

47) Zhao X, Mohaupt M, Jiang J, Liu S, Li B, Qin Z*. 2007. Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis. Cancer Res 67: 4443-50

48) Li Z, Pradera F, Kammertoens T, Li B, Liu S, Qin Z*. 2007. Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection. J Immunol 179: 1568-76

49) Wu TH*, Pabin CN, Qin Z, Blankenstein T, Philip M, Dignam J, Schreiber K, Schreiber H. 2004. Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18. J Immunol 172: 3243-51

50) Qin Z, Blankenstein T*. 2004. A cancer immunosurveillance controversy. Nat Immunol 5: 3-4; author reply -5

51) Kim HJ, Kammertoens T, Janke M, Schmetzer O, Qin Z, Berek C, Blankenstein T*. 2004. Establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin alpha and in the combined absence of functional B and T cells. J Immunol 172: 4037-47

52) Qin Z*, Schwartzkopff J, Pradera F, Kammertoens T, Seliger B, Pircher H, Blankenstein T. 2003. A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells. Cancer Res 63: 4095-100

53) Guo J, Zhang M, Wang B, Yuan Z, Guo Z, Chen T, Yu Y, Qin Z, Cao X*. 2003. Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells. Int J Cancer 103: 212-20

54) Guo J, Chen T, Wang B, Zhang M, An H, Guo Z, Yu Y, Qin Z, Cao X*. 2003. Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1. Immunol Lett 89: 1-7

55) Blankenstein T, Qin Z*. 2003. Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillance. Adv Cancer Res 90: 179-207

56) Blankenstein T, Qin Z*. 2003. The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis. Curr Opin Immunol 15: 148-54

57) Yu Y, Liu S, Wang W, Song W, Zhang M, Zhang W, Qin Z, Cao X*. 2002. Involvement of tumour necrosis factor-alpha-related apoptosis-inducing ligand in enhanced cytotoxicity of lipopolysaccharide-stimulated dendritic cells to activated T cells. Immunology 106: 308-15

58) Qin Z*, Kim HJ, Hemme J, Blankenstein T. 2002. Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction. J Exp Med 195: 1479-90

59) Qin Z*, Harders C, Cao X, Huber C, Blankenstein T, Seliger B. 2002. Increased tumorigenicity, but unchanged immunogenicity, of transporter for antigen presentation 1-deficient tumors. Cancer Res 62: 2856-60

60) Guo J, Wang B, Zhang M, Chen T, Yu Y, Regulier E, Homann HE, Qin Z, Ju DW, Cao X*. 2002. Macrophage-derived chemokine gene transfer results in tumor regression in murine lung carcinoma model through efficient induction of antitumor immunity. Gene Ther 9: 793-803

61) An H, Yu Y, Zhang M, Xu H, Qi R, Yan X, Liu S, Wang W, Guo Z, Guo J, Qin Z, Cao X*. 2002. Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells. Immunology 106: 38-45

62) An H, Xu H, Yu Y, Zhang M, Qi R, Yan X, Liu S, Wang W, Guo Z, Qin Z, Cao X*. 2002. Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways. Immunol Lett 81: 165-9

63) Ibe S, Qin Z*, Schuler T, Preiss S, Blankenstein T. 2001. Tumor rejection by disturbing tumor stroma cell interactions. J Exp Med 194: 1549-59

64) Cayeux S*, Qin Z, Dorken B, Blankenstein T. 2001. Decreased generation of anti-tumor immunity after intrasplenic immunization. Eur J Immunol 31: 1392-9

65) Westermann J*, Kopp J, Korner I, Richter G, Qin Z, Blankenstein T, Dorken B, Pezzutto A. 2000. Bcr/abl+ autologous dendritic cells for vaccination in chronic myeloid leukemia. Bone Marrow Transplant 25 Suppl 2: S46-9

66) Qin Z*, Blankenstein T. 2000. CD4+ T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells. Immunity 12: 677-86

67) Schuler T*, Qin Z, Ibe S, Noben-Trauth N, Blankenstein T. 1999. T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice. J Exp Med 189: 803-10

68) Westermann J*, Aicher A, Qin Z, Cayeux Z, Daemen K, Blankenstein T, Dorken B, Pezzutto A. 1998. Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation. Gene Ther 5: 264-71

69) Uckert W*, Kammertons T, Haack K, Qin Z, Gebert J, Schendel DJ, Blankenstein T. 1998. Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo. Hum Gene Ther 9: 855-65

70) Tong B, Grimes HL, Yang TY, Bear SE, Qin Z, Du K, El-Deiry WS, Tsichlis PN*. 1998. The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Mol Cell Biol 18: 2462-73

71) Qin Z*, Richter G, Schuler T, Ibe S, Cao X, Blankenstein T. 1998. B cells inhibit induction of T cell-dependent tumor immunity. Nat Med 4: 627-30

72) Petersson M*, Charo J, Salazar-Onfray F, Noffz G, Mohaupt M, Qin Z, Klein G, Blankenstein T, Kiessling R. 1998. Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1. J Immunol 161: 2099-105

73) Noffz G*, Qin Z, Kopf M, Blankenstein T. 1998. Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors. J Immunol 160: 345-50

74) Salazar-Onfray F*, Charo J, Petersson M, Freland S, Noffz G, Qin Z, Blankenstein T, Ljunggren HG, Kiessling R. 1997. Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10. J Immunol 159: 3195-202

75) Qin Z*, Noffz G, Mohaupt M, Blankenstein T. 1997. Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells. J Immunol 159: 770-6

76) Qin Z*, Blankenstein T. 1996. Influence of local cytokines on tumor metastasis: using cytokine gene-transfected tumor cells as experimental models. Curr Top Microbiol Immunol 213 ( Pt 3): 55-64

77) Blankenstein T*, Qin Z*. 1996. Cancer vaccines in gene therapy. Gene Ther 3: 95-6

78) Blankenstein T*, Cayeux S, Qin Z. 1996. Genetic approaches to cancer immunotherapy. Rev Physiol Biochem Pharmacol 129: 1-49

79) Qin Z*, van Tits LJ, Buurman WA, Blankenstein T. 1995. Human lymphotoxin has at least equal antitumor activity in comparison to human tumor necrosis factor but is less toxic in mice. Blood 85: 2779-85

80) Qin Z*, Blankenstein T. 1995. Tumor growth inhibition mediated by lymphotoxin: evidence of B lymphocyte involvement in the antitumor response. Cancer Res 55: 4747-51

81) Hock H, Dorsch M, Richter G, Kunzendorf U, Kruger-Krasagakes S, Blankenstein T, Qin Z, Diamantstein T*. 1994. Tumor-cell-targeted cytokine gene transfer in experimental models for cancer therapy. Nat Immun 13: 85-92

82) Qin Z*, Kruger-Krasagakes S, Kunzendorf U, Hock H, Diamantstein T, Blankenstein T. 1993. Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis. J Exp Med 178: 355-60

83) Hock H*, Dorsch M, Kunzendorf U, Uberla K, Qin Z, Diamantstein T, Blankenstein T. 1993. Vaccinations with tumor cells genetically engineered to produce different cytokines: effectivity not superior to a classical adjuvant. Cancer Res 53: 714-6

84) Hock H*, Dorsch M, Kunzendorf U, Qin Z, Diamantstein T, Blankenstein T. 1993. Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma. Proc Natl Acad Sci U S A 90: 2774-8

85) Foss HD, Herbst H*, Oelmann E, Samol J, Grebe M, Blankenstein T, Matthes J, Qin ZH, Falini B, Pileri S, et al. 1993. Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases. Br J Haematol 84: 627-35

86) Uberla K, Li WQ, Qin ZH, Richter G, Raabe T, Diamantstein T, Blankenstein T*. 1991. The rat interleukin-5 gene: characterization and expression by retroviral gene transfer and polymerase chain reaction. Cytokine 3: 72-81

87) Qin ZH, Schuller I, Richter G, Diamantstein T, Blankenstein T*. 1991. The interleukin-6 gene locus seems to be a preferred target site for retrotransposon integration. Immunogenetics 33: 260-6

88) Blankenstein T*, Qin ZH, Uberla K, Muller W, Rosen H, Volk HD, Diamantstein T. 1991. Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer. J Exp Med 173: 1047-52

89) Zheng ZQ*, Qin ZH, Ma AY, Qiao CX, Wang H. 1990. Detection of early pregnancy factor-like activity in human amniotic fluid. Am J Reprod Immunol 22: 9-11

90) Blankenstein T*, Qin ZH, Li WQ, Diamantstein T. 1990. DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma. J Exp Med 171: 965-70

91) Blankenstein T, Qin Z, Uberla K, Volk HD*, Diamantstein T. 1990. Tumor cell targeted cytokine (TNF-alpha) gene therapy for cancer. Immunol Today 11: 431

92) Blankenstein T*, Li WQ, Uberla K, Qin ZH, Tominaga A, Takatsu K, Yamaguchi N, Diamantstein T. 1990. Retroviral interleukin 5 gene transfer into interleukin 5-dependent growing cell lines results in autocrine growth and tumorigenicity. Eur J Immunol 20: 2699-705

93) Richter G, Qin ZH, Diamantstein T*, Blankenstein T. 1989. Analysis of restriction fragment length polymorphism in lymphokine genes of normal and autoimmune mice. J Exp Med 170: 1439-43

94) Qin Z, Richter G, Diamantstein T*, Blankenstein T. 1989. Structure and evolution of mouse interleukin 6 gene. Mol Immunol 26: 1021-6

95) Blankenstein T*, Volk HD, Techert-Jendrusch C, Qin ZH, Richter G, Diamantstein T. 1989. Lack of correlation between BglII RFLP in the human interleukin 6 gene and rheumatoid arthritis. Nucleic Acids Res 17: 8902

96) Qin ZH, Zheng ZQ*. 1987. Detection of early pregnancy factor in human sera. Am J Reprod Immunol Microbiol 13: 15-8

 

From Zhihai Qin, 2018-03-29 update.

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