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Jianyuan Sun, Ph.D, Prof.

Principal Investigator

State Key Laboratory of Brain & Cognitive Sciences, IBP

Molecular and cellular mechanism of synaptic vesicle release

E-mail:jysun@ibp.ac.cn,Tel:010-64888537

Fax:010-64871293,Zip code:100101

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Biography & Introduction

Dr. Sun completed his Ph.D and became a faculty member in the Department of Biology at East China Normal University in 1993. In 1997, He did his postdoctoral fellowship with Dr. Wolf Almers at the Max Planck Institute for Medicine Research in Heidelberg, Germany. During 1999-2002, he worked as a research associate in Dr.Ling-Gang Wu's lab at Washington University in St. Louis. In 2002, he was appointed as an assistant professor(research track) in the Department of Neuroscience, UT Southwestern Medical Center, Dallas. He joined the Institute of Biophysics, Chinese Academy of Sciences, as a principal investigator in 2008.

Dr. Sun’s research interests are focused on the molecular and cellular mechanism of synaptic vesicle release. His laboratory uses an interdisciplinary approach with combination of biophysics and molecular biology to explore the mechanism that the presynaptic secretory machinery achieves the precise neurotransmitter release. He is particularly interested in 1). The molecular mechanism that determines the coupling between calcium channels and synaptic vesicles and how this spatial organization governs vesicle release probability, vesicle release kinetics and synaptic plasticity. 2). The signaling mechanisms that link different modes of synaptic transmitter release to neuronal coding.

Selected Publications

1.Sun J-Y*, Pang ZP, Qin D-Q, Fahim A, Adachi R, and Südhof TC*, A Dual-Ca2+-Sensor Model for Neurotransmitter Release in a central Synapse. NATURE , 450(7170):676-683, 2007

2.Khvotchev M, Dulubova I, Sun J-Y, Dai H, Rizo J, and Sudhof, Dual Modes of Munc18-1/SNARE Interactions Are Coupled by Functionally Critical Binding to Syntaxin-1 N Terminus, JOURNAL OF NEUROSCIENCE, 27(45):12147-55, 2007

3.Sun J-Y*, Bronk P, Liu X, Han W, Südhof TC*. Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway. Proc Natl Acad Sci USA, 103(8):2880-5, 2006

4.Pang ZP, Sun J-Y, Rizo J, Maximov A, Südhof TC. Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO JOURNAL, 25(10):2039-50, 2006(co-first author)

5.Wu, X-S, Sun J-Y, Evers AS, Crowder M, Wu L-G, Isoflurane inhibits transmitter release and the presynaptic action potential, ANESTHESIOLOGY, 100(3):663-670, 2004

6.Sun, J-Y, Wu W, Wu X-S, Jin S-X, Dondzillo A, Wu L-G, Capacitance Capacitance measurements at the calyx of Held in the medial nucleus of the trapezoid body, JOURNAL OF NEUROSCIENCE METHOD, 134(2):121-131, 2004

7.Sun J-Y, Wu X-S, Wu, L-G , Single and multiple vesicle fusion induce different rates of endocytosis at a central synapse, NATURE, 417(6888):555-559, 2002.(co-first author)

8.Sun J-Y, Wu L-G, Fast Kinetics of exocytosis revealed by simultaneous measurements of presynaptic capacitance and postsynaptic currents at a central synapse, NEURON, 30:171-182, 2001.

(*Corresponding author)  

From Jianyuan Sun, 2014-01-20 update

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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Tel:8610-64889872    Fax: 8610-64871293    E-mail: office@ibp.ac.cn