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Jinhui Wang, Ph.D, Prof.

Principal Investigator

State Key Laboratory of Brain & Cognitive Sciences,  IBP

Molecular and cellular mechanisms underlying the precise analysis and computation of neural signals

E-mail:jhw@ibp.ac.cn,Tel:010-64888472

Fax:010-64871293,Zip code:100101

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Biography & Introductions

1992, Ph.D. Shanghai Institute of Physiology, CAS; 1992-1994, Postdoctoral fellow at State University of New York, USA;

1995-1999, Research Scientist at the University of Texas Houston, USA;

1999.8-2004.5, Assistant professor (tenure-track) at the University of Kansas, USA; 2003-12 to present, Professor at the Institute of Biophysics, CAS 

Research interest

Research focuses in my lab include molecular and cellular mechanisms underlying the precise analysis and computation of neural signals at the different cellular compartments (the neurons, synapses and networks), the functional development of inhibitory interneurons, as well as the genetics and neurobiology of functional disorders and ischemic stroke in the brain. Multiple disciplinary approaches are used to address these critical issues such as cellular electrophysiology with patch-clamp in vitro/vivo, cellular imaging by two-photon laser scanning microscopy in vivo, intracellular microinjection to anipulate biochemical reactions or gene expressions, gene analysis in single living neurons, lentivirus and AAV-mediated gene transfer in specific-type of neurons to knock-down or over-express genes, immunohistochemistry, behavioral tasks and math-physical modeling. Our major findings are listed in followings. 1) Homeostasis established through coordinating the function of subcellular compartments improves neuronal encoding. 2) The gain and fidelity of transmission patterns at unitary synapses improve neuronal encoding. 3) VGSC-mediated intrinsic properties navigate the spike encoding of cortical neurons. 4) An increase of intracellular Ca2+ during ischemia deteriorates the signal encoding of GABAergic neurons. 

Major Project funds

1.  Cellular and molecular mechanisms underlying the repairs of cerebral cortices during ischemic stroke. National Basic Research Program (2011CB504405; 1.2 millions)

2.  Cellular and Molecular Mechanisms underlying major depression (2013CB531304; 3 millions).

3.  Animal models for neurological diseases. Natural Science Foundation of China (NSFC 81171033; 0.9 millions).

4.  Molecular mechanisms underlying the development of neural network and memory. Natural National Science Foundation (NSFC 30990261; 3.7 millions).

Selected Publications

1) Jin-Hui Wang and De-Pei Feng (1992). Postsynaptic protein kinase C essential to both induction and maintenance of long-term potentiation in hippocampal CA1 region. Proc. Natl. Acad. Sci. USA, 89, 2576-2580.

2) Jin-Hui Wang and Paul Kelly (1995). Postsynaptic injection of Ca2+/CaM induces synaptic potentiation requiring CaM-KII and PKC activity. Neuron 15(2), 443-452.

3) Jin-Hui Wang and Armin Stelzer (1996). Shared calcium signaling pathways in the induction of long-term potentiation and synaptic disinhibition in CA1 pyramidal cell dendrites. Journal of Neurophysiology. 75 (4), 1687-1701.

4) Jin-Hui Wang and Paul Kelly (1996), Regulation of synaptic facilitation by postsynaptic Ca2+ -CaM signaling pathway in rat hippocampal CA1 neurons. Journal of Neurophysiology. 76,276-286.

5) Jin-Hui Wang and Paul Kelly (1996). The balance between postsynaptic Ca2+-dependent protein kinases and phosphates controlling synaptic strength. Learning & Memory 3, 170-181.

6) Jin-Hui Wang and Paul Kelly (1997). Postsynaptic calcineurin activity down-regulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons. Journal of Neuroscience. 17, 4600-4611.

7) Jin-Hui Wang and Paul Kelly (1997). Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. Journal of Neurophysiology. 78, 2707-2716.

8) Jin-Hui Wang* and Paul Kelly (2001). Ca2+/CaM signal pathway up-regulates glutamatergic synaptic function on non-pyramidal fast-spiking neurons in hippocampal CA1. Journal of Physiology (London) 533(2), 407-422.

9) Mei Zhang, Fen-S Hung Yan Zhu, Zuoping Xie and Jin-Hui Wang* (2004). Calcium signal- dependent multigrade-plasticity of neuronal excitability developed postnatally. Journal of Neurobiology 61, 277-287.

10) Jianning Wei, Mei Zhang, Yan Zhu and Jin-Hui Wang* (2004). Ca2+/CaM signal pathway up-regulates GABA synaptic function through cytoskeleton-mediated mechanisms. Neuroscience 127, 637-647.

11) Na Chen, Xin Chen and Jin-Hui Wang* (2008). Homeostasis by coordination of subcellular compartment plasticity improves spike encoding. Journal of Cell Science, 121(17):2961-2971.

12) Jin-Hui Wang*, J. Wei, X. Chen, J. Yu, N. Chen and J. Shi (2008). The gain and fidelity of transmission patterns at cortical excitatory unitary synapses improves spike encoding. Journal of Cell Science, 121(17):2951-2960.

13) Hong Ni, Li Huang, Na Chen, Dongbo Liu, Fengyu Zhang, Ming Ge, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2010). Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deprivation. PLoS One 5(10):e13736.

14) Na Chen, Jiandong Yu, Hao Qian and Jin-Hui Wang* (2010). Axon amplifies somatic incomplete spikes to uniform. PLoS One 5(7):e11868.

15) Rongjing Ge, Hao Qian and Jin-Hui Wang* (2011). Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons. Molecular Brain 4(19), 1~11.

16) Jiandong Yu, Hao Qian, Na Chen and Jin-Hui Wang* (2011). Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks. PloS One 6(9): e25219.

17) Jun Zhao, Dangui Wang and Jin-Hui Wang* (2012). Barrel cortical neurons and astrocytes coordinately respond to an increased whisker stimulus frequency. Molecular Brain 5,12.

18) Fengyu Zhang, Bei Liu, Zhuofan Lei and Jin-Hui Wang* (2012). mGluR activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: Implication for anxiety-like behavior in DAB/2 mice. Molecular Bain 5(20), 1~12.

19) Bing Ye, Li Huang, Zilong Gao, Ping Chen, Hong Ni, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2012). The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. PLoS One 7(8):e41986.

20) Jiandong Yu, Hao Qian and Jin-Hui Wang* (2012). Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes. Molecular Brain 5(26):1~11.

21) Guanjun Zhang, Zhilong Gao, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2013). Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs. Molecular Brain 6(2): 1~11.

22) Zhilai Yang and Jin-Hui Wang* (2014). Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells. Molecular Brain 7(1):1-13.

23) Rongjing Ge, Hao Qian, Na Chen and Jin-Hui Wang* (2014). Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons. Molecular Brain 7(26):1-16.

24) Wei Lu, Bo Wen, Fengyu Zhang and Jin-Hui Wang* (2014). Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons. Molecular Brain 7(38):1-15.

25) Bei Liu, Jing Feng and Jin-Hui Wang* (2014). Protein kinase C is essential for kainate-induced anxiety-like behavior and glutamatergic synapse upregulation in prefrontal cortex. CNS Neuroscience and Therapeutics 20:982-990.

26) Bo Wen, Hao Qian, Jing Feng, Rong-Jing Ge, Xin Xu, Zhi-Qiang Cui, Ru-Yuan Zhu, Long-Sheng Pan, Zhi-Pei Ling and Jin-Hui Wang* (2015). A portion of inhibitory neurons in human TLE are functionally upregulated: an endogenous mechanism for seizure termination. CNS Neuroscience and Therapeutics 21:204-214.

27) Dangui Wang, Jun Zhao, Zilong Gao, Na Chen, Bo Wen, Wei Lu, Zhuofan Lei, Changfeng Chen, Yahui Liu, Jing Feng and Jin-Hui Wang* (2015). Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals. Frontier in Cellular Neuroscience. 9:320, 1-17.

28) Li Huang, Shidi Zhao, Wei Lu, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2015). Acidosis-induced dysfunction of cortical GABAergic neurons through astrocyte-related excitotoxicity. PLoS One. 10(10): e0140324.

29) Zhuofan Lei, Bei Liu and Jin-Hui Wang* (2015). Reward memory relieves anxiety-related behavior through synaptic strengthening and protein kinase C in dentate gyrus. Hippocampus. DOI:10.1002/hipo.22540. Online.

30) Aiping Xu, Shan Cui and Jin-Hui Wang* (2015). Incoordination among subcellular compartments is associated to depression-like behavior induced by chronic mild stress. International Journal of Neuropsychopharmacology. DOI:10.1093/ijnp/pyv122 Online. 

 

From Jinhui Wang 2015-11-16 update

 

 

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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
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