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Ping Zhu, Ph.D, Prof.
National Laboratory of Biomacromolecules, IBP
Cryo-electron microscopy (cryo-EM); Virus infection and replication;
Chromatin structure and epigenetic regulation.
Biography & Introduction
1986.9-1990.6 B.S., Zhejiang Univ., Hangzhou, China
1990.9-1993.6 M.S., Xi’an Jiaotong Univ., Xi’an, China
1993.9-1997.6 Ph.D., Tsinghua Univ., Beijing, China
1997.7-1998.12 Lecturer, Tsinghua Univ., Beijing, China
1999.3-2008.5 Postdoctoral Research Associate; Assist. in Research (NTTF) ; Associate Scholar/Scientist (NTTF); Florida State Univ., Tallahassee, Florida, USA
2008.6-present Principal Investigator, Professor of “Hundred Talents Program”, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
We are focusing on the structural and functional analysis of virus, chromatin, and other macrobiomolecules, primarily utilizing cryo-electron microscopy (cryo-EM) and electron tomography (ET). Rapidly developed in the past decades, cryo-EM provides a unique way to study the 3D structure of macrobiomolecules in their native status.
The main research interests in the laboratory are: (1) the molecular mechanism of viral assembly, infection and replication; and (2) the higher-order structure of 30nm chromatin fiber and the molecular mechanism of epigenetic regulation. We are also interested in the 3-D structure and function analysis of other functionally important molecular complexes, as well as visualizing the significant biological processes.
Selected Publications (in chronological order)
1. Yao Q, Lu Q, Wan X, Song F, Xu Y, Hu M, Zamyatina A, Liu X, Huang N, Zhu P*, Shao F*. A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family. elife, 2014, 3:e03714 (*corresponding author)
2. Gong M, Zhu H, Zhou J, Yang C, Feng J, Huang X, Ji G, Xu H*, Zhu P*. Cryo-EM study of insect cell-expressed Enterovirus 71 and Coxsackievirus A16 virus-like particles provides a structural basis for vaccine development. J. Virol., 2014, 88:6444-52 (*corresponding author)
3. Song F, Chen P, Sun D, Wang M, Dong L, Liang D, Xu RM, Zhu P*, Li G*. Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units. Science. 2014, 344: 376-80 (*corresponding author, Research Article)
4. Cheng L, Huang X, Li X, Xiong W, Sun W, Yang C, Zhang K, Wang Y, Liu H, Huang X, Ji G, Sun F, Zheng C*, Zhu P*. Cryo-EM structures of two bovine adenovirus type 3 intermediates. Virology, 2014, 450-451:174-81 (*corresponding author)
5. Zhu H, Zhuang J, Feng H, Liang R, Wang J, Xie L*, Zhu P*. Cryo-EM structure of isomeric molluscan hemocyanin triggered by viral infection. PLoS One, 2014, 9(6): e98766 (*corresponding author)
6. Yang C, Ji G, Liu H, Zhang K, Liu G, Sun F, Zhu P*, Cheng L*. Cryo-EM Structure of a transcribing cypovirus. Proc. Natl. Acad. Sci. USA, 2012, 109:6118-23 (*corresponding author)
7. Cheng L, Sun J, Zhang K, Mou Z, Huang X, Ji G, Sun F, Zhang J*, Zhu P*. Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping. Proc. Natl. Acad. Sci. USA, 2011, 108:1373–78 (*corresponding author)
8. Zhu P, Winkler H, Chertova E, Taylor K, Roux K. Cryoelectron tomography of HIV-1 envelope spikes: further evidence for tripod-like legs. PLoS Pathog., 2008, 4(11): e1000203.
9. Zhu P, Liu J, Bess J., Chertova E, Lifson J, Grisé H, Ofek G, Taylor K, Roux K. Distribution and Three-Dimensional Structure of AIDS Virus Envelope Spikes. Nature. 2006, 441:847-852 (Article)
10. Zhu P, Chertova E., Bess J, Lifson J, Arthur L, Liu J, Taylor KA, Roux KH. Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc. Natl. Acad. Sci. USA, 2003, 100:15812-15817
From Ping Zhu, 2014-11-20 update