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IBP Seminar：Molecular mechanism of compound insulin exocytosis, May 13, 2009 |
| Author: |
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Update time: |
2009-05-12 |
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Seminars & Events
From：Scientific Administration Office of IBP
May 12, 2009
IBP Seminar：Molecular mechanism of compound insulin exocytosis, May 13, 2009
| what: |
Molecular mechanism of compound insulin exocytosis |
| who: |
Herbert Y. Gaisano, M.D.
Professor, Departments of Medicine and Physiology, University of Toronto, Canada |
| when: |
Wednesday, May 13, 2009
10：30 p.m. |
| where: |
Lecture Hall , Institute of Biophysics |
| Host: |
Tao Xu, Professor |
| More Information: |
Research in the Gaisano lab has been directed towards elucidating cell signal transduction mechanisms of secretory cells using the model of the pancreatic acinar cell and the insulin-secreting b-cell. Current emphasis has been on molecular mechanisms which regulate the targeting, docking and fusion of the secretory granule with the plasma membrane, i.e. exocytosis. The lab was one of the first to hypothesize that mechanisms involved in the primitive yeast constitutive secretory machinery and the highly regulated neurotransmitter release in mammalian neurons may also be conserved in non-excitable cells to regulate secretion. This hypothesis has now been extended towards the elucidation of the mechanism of insulin exocytosis in pancreatic islet ?-cells. It is hoped that the insights gained from this research will contribute to the long term goal of developing drugs directed at these distal stages of insulin secretion. | |
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