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Songying Ouyang, Ph.D, Prof.
Members of the Youth Innovation Promotion Association, CAS
The mechanism of pathogen infection and innate immune recognition of DNA
Tel: 010-6488 8252
Fax: 010-6488 8426
Zip code: 100101
Lab main page
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Biography & Introduction 
1997-2001  Nanchang University, China, B.S., in Biology
2001-2004  Jilin University (Heping Campus), China, M.S., in Biochemistry and molecule biology
2004-2007  Peking Union Medical College(PUMC), China, Ph.D., in Biochemistry and molecule biology
2007-2010  Assistant Prof., Institute of Biophysics, CAS
2010-2013  Associate Prof., Institute of Biophysics, CAS
2013-2017 Prof., Institute of Biophysics, CAS

2013  LuJiaxi Young Talent Award from Chinese Academy of Sciences
2013  Memberof Youth Innovation Promotion Association from Chinese Academy of Sciences

Research Interest
Specific projects in the lab include 1) Structural and functional studies of important proteins from emerging infectious diseasespathogens; 2) The basic mechanisms of Innate Immune Sensing of DNA.

Selected Publications
1. Li J#, Rodriguez J#, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S*. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci USA. 2016 Nov 15;113(46):13015-13020. (*corresponding author.This article is a PNAS Direct Submission)

Comment in:王璞玥, 杨正宗, 杜生明. STAT6识别N4位点DNA的结构基础被揭示. SCIENTIA SINICA Vitae. DOI: 10.1360/N052016-00324.

Zhou X, Jiang Z. N4 DNA Recognition by STAT6 – Structural and Functional Implications. Protein Cell. 2017 Feb 20. doi: 10.1007/s13238-017-0380-z.

2. Jiang Y, Zhu Y, Liu ZJ, Ouyang S*. The emerging roles of the DDX41 protein in immunity and diseases. Protein Cell. 2017 Feb;8(2):83-89. (*corresponding author)

3. Jiang Y, Zhu Y, Qiu W, Liu YJ, Cheng G, Liu ZJ*, Ouyang S*. Structural and functional analyses of human DDX41 DEAD domain. Protein Cell. 2017 Jan;8(1):72-76. (*corresponding author)

4. Chu Y#, Zhu Y#, Chen Y, Li W, Zhang Z, Liu D, Wang T, Ma J, Deng H, Liu ZJ, Ouyang S*, Huang L*. aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism. Mol Cell Proteomics. 2016 Sep;15(9):2908-23. (*corresponding author)

5. Wang L, Valderramos SG, Wu A, Ouyang S, Li C, Brasil P, Bonaldo M, Coates T, Nielsen-Saines K, Jiang T, Aliyari R, Cheng G. From Mosquitos to Humans: Genetic Evolution of Zika Virus. Cell Host Microbe. 2016 Apr 14. pii: S1931-3128(16)30142-1. (已被引用40次)

6. Jiang Y, Jiang H, Zhou S, Meng B, Liu ZJ*, Ouyang S*. Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding. Biochem Biophys Res Commun. 2016 Mar 18;471(4):621-7. (*co-corresponding author)

7. Ni X#, Ru H#, Ma F#, Zhao L#, Shaw N, Feng Y, Ding W, Gong W, Wang Q, Ouyang S*, Cheng G*, Liu ZJ*. New insights into the structural basis of DNA recognition by HINa and HINb domain of IFI16. J Mol Cell Biol. 2016 Jan 12;8 (1): 51-61. (*co-corresponding author,Cover story)

8. Liu B#, Ouyang S#, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. A primase subunit essential for efficient primer synthesis by an archaeal eukaryotic-type primase. Nat Commun. 2015 Jun 22;6:7300. (#co-first author)

9. Zhao L#, Hua T#, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Jiang Y, Hung LW, Liu L, Ye K, Ouyang S*, Cheng G*, Liu ZJ*. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 2014 Mar; 24(3): 344-58. (*co-corresponding author,已被引用21次)

10. Gu J, Feng Y, Feng X, Sun C, Lei L, Ding W, Niu F, Jiao L, Yang M, Li Y, Liu X, Song J, Cui Z, Han D, Du C, Yang Y, Ouyang S*, Liu ZJ*, Han W*. Structural and biochemical characterization reveals LysGH15 as an unprecedented “EF-hand-like” calcium-binding phage lysin. PLOS Pathogens. 2014 May 15;10(5):e1004109. (*co-corresponding author,已被引用16次)

11. Meng B, Wu D, Gu J, Ouyang S, Ding W, Liu ZJ. Structural and functional analyses of human tryptophan 2,3-dioxygenase. 2014. PROTEINS: Structure, Function, and Bioinformatics. 2014 Nov;82(11):3210-6.

12. Jiao L#, Ouyang S#, Shaw N, Song G, Feng Y, Niu F, Qiu W, Zhu H, Hung LW, Zuo X, Shtykova E, Zhu P, Dong YH, Xu R*, Liu ZJ*. Mechanism of the Rpn13-induced activation of Uch37. Protein Cell. 2014 Aug;5(8):616-30. (#co-first author)

13. Zhang L, Mo J, Swanson K, Wen H, Petrucelli A, Gregory S, Zhang Z, Schneider M, Jiang Y, Fitzgerald K, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan J, Ting J. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity. 2014 Mar 20; 40(3): 329-341. (已被引用60次)

Comment in:Mangan M, Latz E. NLRC3 Puts the Brakes on STING. Immunity. 2014 Mar 20; 40(3): 305-306.

14. Niu F, Ru H, Ding W, Ouyang S*, Liu ZJ*. Structural biology study of human TNF receptor associated factor 4 TRAF domain. Protein Cell. 2013, 4(9): 687-694. (*co-corresponding author,Cover story)

15. Niu F#, Shaw N#, Wang Y#, Jiao L#, Ding W, Upurd H, Ouyang S*, Cheng G*, Liu ZJ*. From the Cover: Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation. Proc Natl Acad Sci USA. 2013 May 28;110(22):9054-9. (*co-corresponding author,已被引用29次。This article is a PNAS Direct Submission)

Comment in:Zheng W, Tao YJ. Genome encapsidation by orthobunyavirus nucleoproteins. Proc Natl Acad Sci U S A. 2013 110 (22) 8769-8770.

16. Jiao L#, Ouyang S#, Liang M#, Niu F#, Shaw N, Wu W, Ding W, Jin C, Peng Y, Zhu Y, Zhang F, Wang T, Li C, Zuo X, Luan CH, Li D, Liu ZJ*. Structure of severe fever with thrombocytopenia syndrome virus nucleoprotein in complex with Suramin reveals therapeutic potentials. J Virol. 2013 Jun;87(12):6829-39. (#co-first author,已被引用34次)

17. Shaw N, Ouyang S, Liu ZJ. Binding of bacterial secondary messenger molecule c di-GMP is a STING operation. Protein Cell. 2013 Feb;4(2):117-29.

18. Parvatiyar K*, Zhang Z*, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol. 2012 Nov 11; 13(8): 1155-1161. (Cover story, 已被引用达173次)

Comment in:“News and Views”by Andrew G Bowie:Innate sensing of bacterial cyclic dinucleotides: more than just STING. Nat Immunol. 2012 Dec;13(12):1137-9.

19. Ouyang S#, Song X#, Wang Y#, Ru H#, Shaw N, Jiang Y, Niu F, Zhu Y, Qiu W, Parvatiyar K, Li Y, Zhang R, Cheng G*, Liu ZJ*. Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding. Immunity. 2012 Jun; 36(6): 1073-1086. (#co-first author,已被引用达119次) (作为当年具有重要影响力的科研成果被中国科学院《2013科学发展报告》收录为“中国科学家代表性成果”;被《中国科学院重大成果年报(2012)》收录,入选《中国科学院国际科技合作年度述评》2012年度报告的《国际科技合作重要进展》)

20. Ouyang S#, Gong B#, Li JZ#, Zhao L#, Wu W, Zhang FS, Sun L, Wang SJ, Pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP, Wang Y*, Liu ZJ*, Liang M*. Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus. J Mol Med (Berl). 2012 July; 90(7):837-846. (#co-first author)

21. Zhan Z#, Ouyang S#, Liang W, Zhang Z, Liu ZJ*, Huang L*. Structural and functional characterization of the C-terminal catalytic domain of the SSV1 integrase. Acta Crystallogr D Biol Crystallogr. 2012 Jun; 68(Pt 6):659-70. (#co-first author)

22. Liang W#, Ouyang S#, Shaw N, Joachimiak A, Zhang R, Liu ZJ. Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE. FASEB J. 2011 Feb; 25(2):497-504.(#co-first author)

23. Qiu XB#*, Ouyang S#, Li CJ, Miao S, Wang L, Goldberg AL*. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 2006 Dec 13;25(24):5742-53. (#co-first author,已被引用达149次)

24. Yin XQ#, Ouyang S#, Xu WM*, Zhang XP, Fok K.L., Zhang JP, Miao SY, Chan HC, and Wang LF. YWK-II as a novel Go protein-coupled receptor for Müllerian Inhibiting Substance in cell survival. J Cell Sci. 2007 May 1;120(Pt 9):1521-8. (#co-first author)


1. 欧阳松应,刘志杰。重要天然免疫系统信号分子STING的结构与功能研究取得重要进展.《2013科学发展报告》,科学出版社,ISBN: 978-7-03-036755-6/N.497

2. 参编《生物信息学方法指南》一书(科学出版社,ISBN 7-03-014465-1,2005年2月)。


From Songying Ouyang, 2017-02-24 update

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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
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