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Eli Song, Ph.D., Associate Professor
Members of the Youth Innovation Promotion Association, CAS
National Laboratory of Biomacromolecules, IBP, CAS
RESEARCH INTERESTS: Molecular Mechanism of Diabetes
Email: songali(AT)ibp.ac.cn
Tel/Fax: +86-10-64888522
Zip code: 100101 

Biography & Introductions

1999.9-2003.7 College of Life Sciences, Beijing Normal University   B.S 
2003.8-2007.6 Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences School of Basic Medicine, Peking Union Medical College   M.S. & Ph.D. 
2007.7-2010.8 National Laboratory of Biomacromolecules, IBP   Assistant Professor  
2010.9- National Laboratory of Biomacromolecules, IBP   Associate Professor 
2014.5-2015.4  Harvard Medical School/Boston Children’s Hospital   Visiting Scientist  
2015.5-2015.9  Harvard Medical School/Boston Children’s Hospital   Research Associate  

Awards and Honors

1. 2018  Scientific and Technological Progress Prize of Henan Province, Second Class, 3rd author

2. 2010  Lu Jia-xi Young Talent Award

3. 2009  Outstanding Doctoral Thesis of Chinese Academy of Medical Sciences/ Peking Union Medical College

Research interest

Molecular Mechanism of Diabetes

Glucose homeostasis is of critical importance to human health, and it is be precisely regulated by insulin. Insulin is a key hormone made by pancreatic beta cells, and its deficiency or resistance are considered as major risk factors in the etiology of type 2 diabetes mellitus. Our researches focus on the beta cell dysfunction resulting in abnormal insulin secretion during the progression of patients from a state of impaired glucose tolerance to diabetes. To achieve the research aims, plenty of advanced techniques are performed, including molecular and biochemical assays, proteomics, transcriptomics, gene editing, animal models, stem cells, organoids, and live cell bioimaging.

Publications(# first author, * corresponding author)

1. Kangmin He#, Eli Song#, Srigokul Upadhyayula#, Song Dang, Raphael Gaudin, Wesley Skillern, Kevin Bu, Benjamin R Capraro, Iris Rapoport, Ilja Kusters, Minghe Ma, Tom Kirchhausen*, Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic, BioRxiv, doi: https://doi.org/10.1101/718726, This article is a preprint.

2. Kuan-Chen Lu, Yujing Zhang, Eli Song*, Extracellular RNA: mechanisms of it’s transporting into target cells, ExRNA, volume 1, Article number: 22 (2019).

3. Xianghua Liu, Ning Sun, Nan Mo, Shan Lu, Eli Song, Chuanchuan Ren, Zhenzhen Li, Quercetin inhibits kidney fibrosis and the epithelial to mesenchymal transition of the renal tubular system involving suppression of the Sonic Hedgehog signaling pathway, Food Function, 2019 Jun 19;10(6):3782-3797.

4. Zhenzhen Li, Yan Wang, Ning Sun, Xianghua Liu, Eli Song, Zhenqiang Zhang, Jianguo Wen, Tao Zheng, Melatonin therapy protects against renal injury before and after release of bilateral ureteral obstruction in rats, Life Sciences, Volume 229, 15 July 2019, 104-115

5. Min Li, Wen Du, Maoge Zhou, Li Zheng, Eli Song*, Junjie Hou*. Proteomic analysis of insulin secretory granules in INS-1 cells by protein correlation profiling. Biophysics Reports, 2018;4(6):329-338.

6. Xinyu Zhu, Min Li, Xiaojun Xu, Rui Zhang, Xiaofei Zhang, Zhuo Ma, Jingze Lu J, Tao Xu*, Junjie Hou*, Eli Song*. hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells. Protein Cell. 2018 Oct;9(10):896-901.

7. Xinyu Zhu, Xiaojun Xu, Kang Du, Jingze Lu, Eli Song*. I-BAR protein IRSp53 regulates clathrin-independent endocytosis in a biphasic manner. Science Bulletin. 2018;63:149-151.

8. Jiajun Fu, Haining Zhang, Wenming Huang, Xinyu Zhu, Yi Sheng, Eli Song*, Tao Xu*. AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans. Biophysics Reports. 2018;4(1):17-24.

9. Kangmin He*, Robert Marsland III, Srigokul Upadhyayula, Eli Song, Song Dang, Benjamin R. Capraro, Weiming Wang, Wesley Skillern, Raphael Gaudin, Minghe Ma, and Tom Kirchhausen*, Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic, Nature, 2017, 552, 410–414.

10. Xiaobing Li, Xianghua Liu, Ji Li, ELi Song, Ning Sun, Wen Liu, Tian Wang, Jinchang Yang, and Zhenzhen Li*, Semaphorin-3A and Netrin-1 predict the development of kidney injury in children with congenital hydronephrosis, Scandinavian Journal of Clinical and Laboratory Investigation, 2017, Dec 3:1-7.

11. Wen Du, Maoge Zhou, Wei Zhao, Dongwan Cheng, Lifen Wang, Jingze Lu, Eli Song, Wei Feng, Yanhong Xue, Pingyong Xu, Tao Xu*, HID-1 is required for homotypic fusion of immature secretory granules during maturation, eLife, 2016; 5: e18134.

12. Pingping Lv, Yi Sheng, Zhenao Zhao, Wei Zhao, Lusheng Gu, Tao Xu*, Eli Song*, Targeted disruption of Rab10 causes early embryonic lethality, Protein Cell, June 2015, Volume 6, Issue 6, pp 463-467

13. Yan Chen, Zhiping Xia, Lifen Wang, Yong Yu, Pingsheng Liu, Eli Song*, Tao Xu*, An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells, Biophysics Reports, August 2015, Volume 1, Issue 1, pp 34-40

14. Zhiping Xia, Yan Chen, Yi Sheng, Yalan Yi, Eli Song*, Tao Xu*,Whole Genome RNAi Screen in C. elegans Identifies CAB-1 as a Novel Regulator of DCV Secretion, Progress in Biochemistry and Biophysics, 2014, 41(8): 787-795

15. Zhengguang Guo#, Eli Song#,*, Sucan Ma, Shijuan Gao, Xiaorong Wang, Chen Shao, Siqi Hu, Lulu Jia, Dexian Zheng, Tao Xu and Youhe Gao*, A Proteomics Strategy to Identify Substrates of LNX, a PDZ Domain Containing E3 Ubiquitin Ligase, Journal of Proteome Research, 2012 Oct 5;11(10):4847-62

16. Yu Chen, Yan Wang, Jinzhong Zhang, Yongqiang Deng, Li Jiang, Eli Song, Xufeng S. Wu, John A. Hammer, Tao Xu*, Jennifer Lippincott-Schwartz*, Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes, Journal of Cell Biology, 2012 198:545-560

17. Lifen Wang#, Yi Zhan#, Eli Song#, Yong Yu, Yaming Jiu, Wen Du, Jingze Lu, Pingsheng Liu1, Pingyong Xu, Tao Xu, HID-1 is a peripheral membrane protein primarily associated with the medial- and trans-Golgi apparatus, Protein Cell. 2011, 2(1): 74–85.

18. Yong Yu#, Lifen Wang#, Yaming Jiu#, Yi Zhan, Lin Liu, Zhiping Xia, Eli Song, Pingyong Xu* and Tao Xu*, HID-1 is a novel player in the regulation of neuropeptide release, Biochem Journal. 2011 Mar 15;434(3):383-90.

19. Lulu Jia, Ling Zhang, Chen Shao, Eli Song, Wei Sun, Mingxi Li, and Youhe Gao, An attempt to understand kidney’s protein handling function by comparing plasma and urine proteomes, PloS ONE, 2009, 4(4):e5146

20. Siqi Hu, Eli Song, Rui Tian, Sucan Ma, Tao Yang, Yi Mu, Yuan Li, Chen Shao, Shijuan Gao and Youhe Gao*, Systematic analysis of a simple adaptor protein PDZK1: ligand identification, interaction and functional prediction of complex. Cellular Physiology and Biochemistry, 2009, 24:231–242

21. Sucan Ma#, Eli Song#, Shijuan Gao, Rui Tian, Youhe Gao*,Rapid Characterization of the Binding Property of HtrA2/Omi PDZ Domain by Validation Screening of PDZ Ligand Library,Science in China Series C: Life Sciences, 2007, 50(3), 412-422,

22. Eli Song#, Shijuan Gao#, Rui tian#, Sucan Ma, Haiming Huang, Jiayan Guo, Yingna Li, Ling Zhang, Youhe Gao*,A High-Efficiency Strategy for Binding Property Characterization of Peptide Binding Domains, Molecular & Cellular Proteomics, 2006, 5 (8), 1368-1381.

23. Eli Song*, Life Science and Biotechnology in China, Bio-science Law Review, 2006, 7 (6), 224-228

Book Chapters

1. Tao Xu, Eli Song, Rongying Zhang, Molecular Cell Biology (Third Edition, Higher Education Press), Chapter 5, Cellular Vesicle Transportation, 99-118.

2. Liangyi Chen and Eli Song. Using molecular imaging techniques to study protein-protein interactions. Molecular Imaging-Fundamentals and Applications (Springer Press), Part III, Chapter 18, 633-659.

3. Eli Song and Youhe Gao. Protein-protein interaction and diseases, Human Pathophysiology (Third Edition, People's Medical Publishing House Co., LTD), Chapter 2, Section 5, Protein-protein Interaction and Disease, 38-51.


Title: A validation screening method for binding ligands of peptide-binding domains

Inventor: Youhe Gao, Eli Song, Shijuan Gao, Rui Tian, Sucan Ma, Haiming Huang

Patent Number: ZL.200610057182.1


From Eli Song, 2019-11-25 update

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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
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