Xiangming Wang Ph.D,  Associate professor Members of the Youth Innovation Promotion Association, CAS PVD neuron morphogenesis and maintenance in C. elegans E-mail: xmwang@moon.ibp.ac.cn Phone: 010-64889515 Fax: 010-64889515 Chinese personal homepage

Biography & Introduction

2014.1 - now Institute of Biophysics, CAS  Research associate
2010.7 - 2013.12 Institute of Biophysics, CAS, Research assistant
2008.7 - 2010.6 China Academy of Chinese Medical Sciences, Postdoc
2002.9 - 2008.7 Peking University, Ph.D
2005.1 - 7 UCSC, Visiting Scholar
1998.9-2002.7 Yantai University, Bachelor

Research interests
Dendrites are the branched projections of a neuron which receive signals from other neural cells. They play a critical role in integrating synaptic inputs to the cell body. The malfunction of dendrites has been shown to be associated with many human diseases, such as autism, Down, Rett, Fragile-X syndrome et al.I am interested in the molecular mechanism of dendrite morphogenesis and maintenance. Here I will use the PVD neuron of  C. elegans as the model system to isolate new genes controlling PVD neuron development and maintenance.

Selected publications(#=first author, *=corresponding author)

1. Xianzhuang Liu, Xiangyang Guo, Liling Niu, Xixia Li, Fei Sun, Junjie Hu, Xiangming Wang*, and Kang Shen*, Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites, Nat. Commun., 2019, Feb 4;10(1):568.

2. Rui Dong, Ting Zhu, Lorena Benedetti, Swetha Gowrishankar, Huichao Deng, Yiying Cai, Xiangming Wang, Kang Shen*，Pietro De Camilli*,The inositol 5-phosphatase INPP5K participates in the fine control of ER organization, J Cell Biol. 2018 Oct 1;217(10):3577-3592.

3. Shuai Zhang, Zhibin Fan, Ping Qiao, Yinsuo Zhao, Yanan Wang, Da Jiang, Xiangming Wang, Xiaojuan Zhu, Yu Zhang, Baiqu Huang, Jun Lu*, Xiaoxue Li*, miR-51 regulates GABAergic synapses by targeting Rab GEF GLO-4 and lysosomal trafficking-related GLO/AP-3 pathway in Caenorhabditis elegans, Dev Biol. 2018, Apr 1;436(1):66-74.

4. Ting Zhu#, Xing Liang#, Xiangming Wang*, Kang Shen*, Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells, J Cell Sci., 2017, 130(23):4063-4071.

5. Xianzhuang Liu, Xiangming Wang*, and Kang Shen*, Receptor tyrosine phosphatase CLR-1 acts in skin cells to promote sensory dendrite outgrowth, Dev Biol. 2016 May 1;413(1):60-9.

6. Xiangming Wang*, Jianhong Liu, Zhiwen Zhu, Guangshuo Ou, The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration, Dev Biol., 2015, 399(2): 306-14.

7. Xing Liang, Xintong Dong, Moerman, D. G., Kang Shen*, and Xiangming Wang*, Sarcomeres Pattern Proprioceptive Sensory Dendritic Endings through UNC-52/Perlecan in C. elegans, Dev. cell, 2015, 33(4): 388-400.

    Preview in the same isuue: Jiang N, Parrish JZ.Muscles get dendrites into shape. Developmental cell, 2015, 33, 369-370.

8. Xiangming Wang, Fanli Zhou, Sijing Lv, Peishan Yi, Zhiwen Zhu, Yihong Yang, Guoxin Feng, Wei Li, and Guangshuo Ou*, Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration, Proc Natl Acad Sci U S A., 2013, 110(27): 11175-11180.　　

9. Ze Cheng#, Peishan Yi#, Xiangming Wang, Yongping Chai, Guoxin Feng, Yihong Yang, Xing Liang, Zhiwen Zhu, Wei Li*& Guangshuo Ou*, Conditional targeted genome editing using somatically expressed TALENs in C. elegans, Nature Biotechnology, 2013, volume 31, pages 934–937.　　

10. Guoxin Feng#, Peishan Yi#, Yihong Yang#, Yongping Chai#, Dong Tian, Zhiwen Zhu, Jianhong Liu, Fanli Zhou, Ze Cheng, Xiangming Wang, Wei Li, Guangshuo Ou*, Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression, Development, 2013, 140: 3838-3847.　　

11. Yongping Chai#, Wei Li#, Guoxin Feng, Yihong Yang, Xiangming Wang & Guangshuo Ou*, Live imaging of cellular dynamics during Caenorhabditis elegans postembryonic development, Nat Protoc. 2012, Dec;7(12):2090-102.　　

12. Xiangming Wang*, Xiaoyan Wang, Lianda Li, Danqiao Wang*, Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16, Biochem Biophys Res Commun. 2010, Oct 1;400(4):613-8.　　

13. Xiangming Wang#, Min Liu#, Weida Li, Christopher D. Suh, Zuoyan Zhu, Yishi Jin, Qichang Fan*, The function of a spindle checkpoint gene bub-1 in C. elegans development, PLoS One. 2009, Jun 15;4(6):e5912.　

14. Xiangming Wang, Christopher D. Suh, Zuoyan Zhu, Qichang Fan*, Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development, Biochem Biophys Res Commun. 2007, Aug 10;359(4):965-71.

Patents 

Xiangming Wang, Danqiao Wang, Xiaoyan Wang, et. al, The application of DMSO in making anti-aging products. Accepted patent number: 200910244038.2

Xiaoyan Wang, Danqiao Wang, Xiangming Wang, et. al, The application of Chuanxiong Extract in making anti-aging products. Accepted patent number: 200910243699.3

From Xiangming Wang, 2019-11-22 update