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  Yanying Wang, Ph.D, Associate Professor
  Member of the Youth Innovation Promotion Association of CAS
  Cancer immunology
  E-mail: wangyanying@moon.ibp.ac.cn,
  Tel: 010-64884329
  Fax: 64871293, Zip code: 100101

Biography & Introduction

1999.9-2002.7 College of life sciences, Shandong University

2005.9-2008.7 Master, Beijing University of Agriculture

2008.8-2011.12Ph.D., Institute of Basic Medical Sciences, Peking Union Medical College

2012.1-2015.12Assistant professor, Institute of Biophysics, Chinese Academy of Sciences

2016.1-Present Associate professor, Institute of Biophysics, Chinese Academy of Sciences

Awards and Honors

2008 Excellent Graduate Studentin the graduate school, Beijing University of Agriculture

2008 Excellent MA theses, Beijing University of Agriculture

2002 Excellent Graduate Student, Shandong University

Research interest

Cancer stem cells (CSCs)possess the ability to self-renew and differentiate. CSCs may contribute to tumor initiation, metastasis, recurrence as well as drug resistance. Our current research interest is to study the molecular mechanisms of liver CSCs self-renewal, discover novel markers of liver CSCs, and provide novel drug targets for personal therapy of liver cancer.

Selected Publications

1. Wang Y#, He L#, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, and Fan Z. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015; 16 (4);413-425. ( #co-first author)  

2. Zhu P#, Wang Y#, Huang G, Ye B, Liu B, Wu J, Du Y, He L, and Fan Z. lnc-beta-Catm elicits EZH2-dependent beta-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 2016; 23(7); 631-639. (#co-first author)

3. Zhu P#, Wang Y#, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, and Fan Z. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608. ( #co-first author)

4. Zhu P#, Wang Y#, He L#, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, and Fan Z. Zic2 Drives Self-renewal of Human Liver Cancer Stem Cells. J Clin Invest. 2015;125(10):3795–3808( #co-first author)

5. Zhu P, Wang Y, Du Y, He L, Huang G, Zhang G, Yan X, and Fan Z. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signaling. Nat Commun. 2015;6:7122.   

6. Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y, and Fan Z. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014, 211: 2439-2454.   

7. Yang X, Xu M, Wang Y, Xia P, Wang S, Ye B, Tong L, Jiang T, and Fan Z. Molecular mechanism for self-protection against type VI secretion system in Vibrio cholerae. Acta Crystallogr D Biol Crystallogr.2014, 70(4): 1094-1103.  

8. Wang Y, Song G, Qiu L, Qin X, Liu H, Li F, Wang X, Guo S, Zhang Y, and Li Z. Elevated Serum Levels of Circulating Immunoinflammation-Related Protein Complexes Are Associated with Cancer. J Proteome Res. 2014, 13(2): 710-719.   

9. Song G, Liu Y, Wang Y, Ren G, Guo S, Ren J, Zhang L, and Li Z. Personalized biomarkers to monitor disease progression in advanced non-small-cell lung cancer patients treated with icotinib. Clinica Chimica Acta.2015, 440:44-48.   

10. Chen G, Wang Y, Qin X, Li H, Guo Y, Wang Y, Liu H, Wang X, Song G, Li F, Guo S, Qiu L, and Li Z. Change in IgG1 Fc N-linked glycosylation in human lung cancer: age- and sex-related diagnostic potential. Electrophoresis. 2013, 34: 2407-2416.   

11. Chen G, Zhang L, Wang Y, Guo Y, Liu H, and Li Z. Letter to the editor. Probing gender-specific change in IgG1 Fc-galactosylation in non-small cell lung cancer patients treated with epidermal growth factor receptor inhibitor. Rapid Commun Mass Spectrom. 2013, 27, 1168-1172.   

12. Chen G, Wang Y, Qiu L, Qin X, Liu H, Wang X, Wang Y, Song G, Li F, Guo Y, Li F, Guo S, and Li Z. Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer. J Proteomic. 2012, 75(10), 2824-2834.   

13. Guo Y, Wang X, Qiu L, Qin X, Liu H, Wang Y, Li F, Chen G, Song G, Guo S, and Li Z. Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry. Clin Chim Acta. 2012, 414, 135-141.   

14. Wang Y, Zhang Z, Shen H, Lu Y, Li H, Ren X, Wu G. TGF-β1/Smad7 signal pathway stimulates renal tubuloinsterstitial fibrosis induced by AAⅠ. J Recept Sig Transd Res. 2008, 28: 4, 413-428.   

15. Li J, Zhang Z, Wang D, Wang Y, Li Y, and Wu G. TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Sig Transd Res. 2009, 29(5): 280-285.


From Yanying Wang,2019-11-25



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