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   Qian Wu, Ph.D., Associate Prof. 

  Members of the Youth Innovation Promotion Association, CAS 

  State Key Laboratory of Brain & Cognitive Sciences, IBP 

  Cellular basis and molecular regulation of neurogenesis

        in brain development and brain disease.

  E-mail: qianwu@moon.ibp.ac.cn

  Tel: 010-64887377, Zip code: 100101 

  Chinese personal homepage   

Biography & Introduction   

1999.9 - 2003.7  Beijing Normal University,  B.S. in Biotechnology

2003.8 - 2008.4  University of Pittsburgh,  Ph.D. in Molecular, Cellular and Developmental Biology

2004.8 - 2008.4  University of Pittsburgh,  Minor Degree in Teaching in the Biological Sciences

2008.5 - 2011.9  University of Pittsburgh,  Postdoctoral Training

2011.10- 2017.12  Institute of Biophysics,  Associate Professor

2018.1- 2018 Institute of Biophysics, Professor

Research Interests

I am interested in the understanding of cellular basis and molecular regulation of neurogenesis in brain development and nervous system diseases.

Selected Publications

1. Zhong S*, Zhang S*, Fan X*, Wu Q*, Yan L*, Dong J, Zhang H, Li L, Sun L, Pan N, Xu X, Tang F#, Zhang J#, Qiao J#, Wang X#. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature. 2018 Mar 22;555(7697):524-528. (*Equal contribution)

2. Shi Y*, Li S*, Wu Q*, Sun L, Zhang J, Pan N, Wang Q, Bi Y, An J, Lu X, Gao GF, Wang X. Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring. Sci Rep. 2018 Feb 23;8(1):3541. (*Equal contribution)

3. Liu J*, Liu W*, Yang L*, Wu Q*, Zhang H, Fang A, Li L, Xu X, Sun L, Zhang J, Tang F, Wang X. The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding, Cell Stem Cell. 2017 Nov 2;21(5):635-649.e8. (*Equal contribution)

4. Li R, Sun L, Fang A, Li P, Wu Q*, Wang X*. Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like(ASPM related primary) microcephaly disease. Protein Cell. 2017 Nov;8(11):823-833. (* Corresponding authors)

5. Wang Y*, Wu Q*, Yang P, Wang C, Liu J, Ding W, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 2016 Jan 22;7:10481. doi: 10.1038/ncomms10481. (*Equal contribution)

6. Kou Z*, Wu Q*, Kou X*, Yin C*, Wang H, Zuo Z, Zhuo Y, Chen A, Gao S, Wang X. CRISPR/Cas9-mediated genome engineering of the ferret. Cell Res. 2015 Dec;25(12):1372-5. doi: 10.1038/cr.2015.130. (*Equal contribution)

7. Li R, Bai Y, Liu T, Wang X*, Wu Q*. Induced pluripotency and direct reprogramming: a new window for treatment of neurodegenerative diseases. Protein Cell. 2013 Jun;4(6):415-24. (* Corresponding authors)

8. Wu Q, Wang X. Neuronal stem cells in the central nervous system and in human diseases. Protein Cell. 2012 Apr;3(4):262-70.

9. Chao Y, Wu Q, Acquafondata M, Dhir R, Wells A, Partial Mesenchymal to Epithelial Reverting Transition in Breast and Prostate Cancer Metastases. Cancer Microenviron. 2012 Apr;5(1):19-28.

10. Wu Q, Dhir R, Wells A, Altered CXCR3 Isoform Expression Regulates Prostate Cancer Cell Migration and Invasion. Mol Cancer. 2012 Jan 11;11(1):3.

11. Chao Y*, Wu Q*, Shepard C, Wells A, Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance. Clin Exp Metastasis. 2012 Jan;29(1):39-50. (*Equal contribution)

12. Wells A, Chao YL, Grahovac J, Wu Q, Lauffenburger DA. Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. Front Biosci. 2011 Jan 1;16:815-37.

13. Wu Q, Sahasrabudhe RM, Luo LZ, Lewis DW, Gollin SM, Saunders WS. Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells. Oncogene. 2010 Jul 22;29(29):4183-93.

14. Wu Q, Xu FL, Li Y, Prochownik EV, Saunders WS. The c-Myc target Glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cells. PLoS One. 2010 May 25;5(5):e10819.

15. Li M, Aliotta JM, Asara JM, Wu Q, Dooner MS, Tucker LD, Wells A, Quesenberry PJ, Ramratnam B. Intercellular transfer of proteins as identified by stable isotope labeling of amino acids in cell culture. J Biol Chem. 2010 Feb 26;285(9):6285-97.

Book Chapters

1. Wu Q, Liu J, Fang A, Li R, Bai Y, Kriegstein AR, and Wang X, Chapter2: The Dynamics of Neuronal Migration, Cellular and Molecular Control of Neuronal Migration, 1st Edition, 2014, Springer, ISBN 978-94-007-7687-6.

2. Wells A, Chao YL, Wu Q, Chapter 58: Biology of metastatic liver tumors, Molecular Pathology of Liver Diseases, 1st Edition, 2011, Springer, ISBN: 978-1-4419-7106-7.


From Qian Wu, 2017-03-27

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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Tel:8610-64889872    Fax: 8610-64871293    E-mail: office@ibp.ac.cn