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  Xi Wang, Ph.D, Associate Professor 

  Members of the Youth Innovation Promotion Association, CAS 

  National Laboratory of Biomacromolecules, IBP 

  Oxidative protein folding in the endoplasmic reticulum  

  E-mail: wangxi(AT)moon.ibp.ac.cn  

  Tel: 010-64888501

  Fax: 010-64840672   

  Zip code: 100101 

  Chinese personal homepage  

Biography & Introduction

Education & Positions   

09/1999-06/2003 B.Sc. in Biology, College of Life Sciences, Wuhan University, Wuhan   

09/2003-06/2008 Ph.D in Biochemistry and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing   

07/2008-12/2011 Research Associate, Institute of Biophysics, Chinese Academy of Sciences, Beijing   

01/2012- Associate Professor, Institute of Biophysics, Chinese Academy of Sciences, Beijing   

12/2015-12/2016 Visiting Scholar, The Scripps Research Institute, La Jolla, CA, USA   

Grants

1. NSFC General Program, “Regulation of redox homeostasis in the endoplasmic reticulum via oxidoreductases”, 2019-2022    

1. NSFC General Program, “Molecular mechanism and structural basis of peroxiredoxin 4 mediated oxidative protein folding pathway”, 2014-2017

2. NSFC Young Scientists Program, “Roles of human quiescin-sulfhydryl oxidase1 in oxidative protein folding and quality control”, 2010-2012   

Research Interests   

Disulfide formation is one of the key rate-limiting steps in oxidative protein folding, which is vital for the stability of many secretory and cell-surface proteins and redox regulation of protein activities in some cases. Dr. Xi Wang worked on the structure-function relationships and molecular mechanisms of essential enzymes in oxidative protein folding. His recent research interests also include studying the proteostasis regulation and its impacts on human healthspan through a multidisciplinary application of cell biological, biochemical, and structural approaches.   

Selected publications   

1. Shili Xu, Yajing Liu, Kai Yang, Hanxiao Wang, Andrea Shergalis, Anahita Kyani, Armand Bankhead III, Shuzo Tamura, Suhui Yang, Xi Wang, Chih-chen Wang, Alnawaz Rehemtulla, Mats Ljungman, Nouri Neamati (2019) Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes. Theranostics 9:2282-2298. 

2. Yini Zhang, Tao Li, Lihui Zhang, Fugen Shangguan, Guizhi Shi, Xun Wu, Ya Cui, Xi'e Wang, Xi Wang, Yongzhang Liu, Bin Lu, Taotao Wei, Chih-chen Wang, Lei Wang (2019) Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer. EBioMedicine 41:408-419.

3. Jianchao Zhang, Qinyu Zhu, Xi'e Wang, Jiaojiao Yu, Xinxin Chen, Jifeng Wang, Xi Wang, Junyu Xiao, Chih-chen Wang, Lei Wang (2018) Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α. EMBO J., 37:e98699.  

4. Kai Yang, De-Feng Li, Xi’e Wang, Jinzhao Liang, Roberto Sitia, Chih-chen Wang#, Xi Wang# (2016) Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention. Structure, 24:1755-1765. (#co-corresponding author)   

5. Lei Wang*, Xi Wang*, Chih-chen Wang (2015) Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone. Free Radic Biol Med, 83:305-13. (*co-first author)   

6. Li Zhu, Kai Yang, Xi’e Wang, Xi Wang# and Chih-chen Wang# (2014) A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding. PLoS One, 9:e105529. (#co-corresponding author)   

7. Shang Yang*, Xi Wang*, Lei Cui, Xiang Ding, Lili Niu, Fuquan Yang, Chao Wang, Chih-chen Wang, Jizhong Lou (2014) Compact conformations of human protein disulfide isomerase. PLoS One, 9:e103472. (*co-first author)   

8. Xi Wang*, Likun Wang*, Xi’e Wang, Fei Sun and Chih-chen Wang (2012) Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. Biochem J., 441:113–118. (*co-first author)   

9. Chao Wang, Sihong Chen, Xi Wang, Lei Wang, A. Katrine Wallis, Robert B. Freedman and Chih-chen Wang (2010) Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance. J Biol Chem., 285: 26788-97.   

10. Guoping Ren*, Xi Wang*, Shufeng Hao, Hongyu Hu and Chih-chen Wang (2007) Translocation of alpha-synuclein expressed in Escherichia coli. J Bacteriol., 189: 2777-86. (*co-first author)

  

From Xi Wang, 2019-10-16

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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Tel:8610-64889872    Fax: 8610-64871293    E-mail: office@ibp.ac.cn