 | Chao-Pei Liu, Ph.D, Associate Professor Member of the Youth Innovation Promotion Association of CAS National Laboratory of Biomacromolecules, IBP, CAS Histone chaperones structural biology E-mail: liuchaopei(AT)moon.ibp.ac.cn Tel: 010-64888390 Fax: 010-64888023 Zip code: 100101 |
Biography & Introduction
2001.09-2005.06 B.S., Physics, Hunan Normal University, Changsha, China
2005.09-2010.06 Ph.D., Condensed Matter Physics, Institute of High Energy Physics, CAS
2010.07-2013.03 Postdoc, Institute of Biophysics, CAS
2013.04-Pre. Associate professor, Institute of Biophysics, CAS
Grants
2019-2024 National Key Research and Development Program of China
2017-2022 National Key Research and Development Program of China, Young Scientists Program
2016-2019 National Natural Science Foundation of China, General Program
2015-2019 National Natural Science Foundation of China, State Key Program
2014-2016 National Natural Science Foundation of China, Young Scientists Program
Research Interest
Dr. Liu’s work mainly focus on histone chaperones structural biology. The fundamental repeating unit of chromatin is the nucleosome: histone octamer surrounded by 147 bp of DNA. Nucleosomes are dynamically displaced and reassembled to allow access to the underlying DNA for transcription, replication, and DNA damage repair. Histone chaperones binding with histone H3.1 or its variants, such as CAF-1, NASP, HIRA and DAXX, are central to the processes of nucleosome assembly and disassembly. We aim to gain the 3D structures of these complexes of interest by X-ray crystallography and cryo-EM techniques, and to uncover the molecular mechanism of histone chaperone recognition through biochemical and cell biology approaches.
Selected Publications (First author#, Correspondence*)
1. Peini Hou#, Chang Huang#, Chao-Pei Liu, Na Yang, Tianshu Yu, Yuxin Yin, Bing Zhu*, Rui-Ming Xu*. Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. Structure, 2019, 27(5):837-845.e3.
2. Chaoyang Xiong#, Zengqi Wen#, Juan Yu, Jun Chen, Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu, Guohong Li. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells. BMC Biol. 2018, 16(1):110.
3. Wenxing Jin#, Yi Wang#, Chao-Pei Liu#, Na Yang, Mingliang Jin, Yao Cong, Mingzhu Wang* and Rui-Ming Xu*. Structural basis for snRNA recognition by the double WD40-repeat domain of Gemin5. Genes & Development, 2016, 30(21): 2391-2403.
4. Chao-Pei Liu#, Chaoyang Xiong#, Mingzhu Wang, Zhouliang Yu, Na Yang,Ping Chen, Zhiguo Zhang, Guohong Li* and Rui-Ming Xu*. Structure of the variant histone H3.3–H4 heterodimer in complex with its chaperone DAXX. Nature Structural & Molecular Biology, 2012, 19(12): 1287-1292.
5. Ying Liu, Zeng-Qiang Gao, Chao-Pei Liu, Jian-Hua Xu, Lan-Feng Li, Chao-Neng ji, Xiao-Dong Su and Yui-Hui Dong (2011). Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans. Acta Crystallogr Sect F Struct Biol Cryst Commun, 67(Pt 2):182-7.
6. Chao-Pei Liu, Rui Xu, Zeng-Qiang Gao, Jian-Hua Xu, Hai-Feng Hou, Li-Qin Li, Zhun She, Lan-Feng Li, Xiao-Dong Su, Peng Liu and Yui-Hui Dong (2010). Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans. Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 5):498-502.
From Chao-Pei Liu, 2019-11-25
