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  Hong-Xia Duan, Ph.D, Associate Professor
  Member of the Youth Innovation Promotion Association of CAS
  Key Laboratory of Protein & Peptide Pharmaceuticals, Institute of Biophysics
  Tumor immunology
  E-mail: cherryshoen(AT)aliyun.com 
  Tel: 010-64888503
  Zip code: 100101

Biography & Introduction

2002-2007 Wuhan University of Science and Technology, Bachelor of Medicine

2007-2009 HuaZhong University of Science and Technology, Master of Medicine

2009-2013 University of Chinese Academy of Sciences, Ph.D

2013-2016 Institute of Biophysics, CAS, post-doctor

2017-Institute of Biophysics, CAS, Associate professor

Research Interest

It has been well recognized that there is a close relationship between chronic non-resolving inflammation and malignant transformation. However, the molecular mechanism of this process is not clear. In the past three years, we have been focusing on cancer-related inflammation, angiogenesis and metastasis. Our study provided important evidence that CD146, as a node molecule, links chronic non-resolving inflammation and malignant transformation. Based on the established the endogenous molecular–cellular network of CD146+ immune cells, we will predict the candidate molecules in controlling the function conversion of CD146+ immune cells, including the crosstalk with other immune cells, stromal cells and liver cells. Collectively, our study will provide a novel marker for functional switch of tumor-associateimmune cells during HCC initiation. Our study will also provide a new treatment strategy for HCC.

Selected Publications

1. Daji Wang#, Hongxia Duan#, Jing Feng, Jianquan Xiang, Liqun Feng, Dan Liu, Xuehui Chen, Lin Jing, Zheng Liu, Dexi Zhang, Hongjun Hao, Xiyun Yan. Soluble CD146, a cerebrospinal fluid marker for neuroinflammation, promotes blood-brain barrier dysfunction. (#Co-first author) Theranostics 2020, Vol. 10, Issue 1.

2. Shuai Zhao, Hongxia Duan, Yili Yang, Xiyun Yan*, Kelong Fan*. Fenozyme Protects the Integrity of the Blood–Brain Barrier against Experimental Cerebral Malaria. Nano Lett 2019.

3. Yongting Luo#, HongxiaDuan#, Yining Qian#, Liqun Feng, Zhenzhen Wu, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan. Macrophage CD146 promotes atherosclerosis by trapping macrophages in the plaques. (#Co-first author) Cell Res. 2017 Mar;27(3):352-372

4. Duan H, Xing S, Luo Y, Feng L, Gramaglia I, Zhang Y, Lu D, Zeng Q, Fan K, Feng J, Yang D, Qin Z, Couraud PO, Romero IA, Weksler B, Yan X. Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS. Sci Rep. 2013;3:1687.

5. Duan H, Luo Y, Hao H, Feng L, Zhang Y, Lu D, Xing S, Feng J, Yang D, Song L, Yan X. Soluble CD146 in cerebrospinal fluid of active multiple sclerosis. Neuroscience. 2013 Apr 3;235:16-26.

6. Jiang T, Zhuang J, Duan H, Luo Y, Zeng Q, Fan K, Yan H, Lu D, Ye Z, Hao J, Feng J, Yang D, Yan X. CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood. 2012 Sep 13;120(11):2330-9.

7. Zeng Q, Li W, Lu D, Wu Z, Duan H, Luo Y, Feng J, Yang D, Fu L, Yan X. CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer. ProcNatlAcadSci U S A. 2012 Jan 24;109(4):1127-32.

8. Qian YN, Luo Y, Duan HX, Feng LQ, Bi Q, Wang YJ, Yan XY. Adhesion Molecule CD146 and its Soluble Form Correlate Well with Carotid Atherosclerosis and Plaque Instability. CNS NeurosciTher. 2014; 20(5):438-45.

9. Shu Xing, Luo Y, Zhihua Liu, Pengcheng Bu, Hongxia Duan, Dan Liu, Ping Wang, Jing Yang, Lina Song, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan. Targeting endothelial CD146 attenuates colitis and prevents colitis-associated-carcinogenesis. Am J Pathol. 2014; 184:1604-16.

10. Wang P, Luo Y, Duan H, Xing S, Zhang J, Lu D, Feng J, Yang D, Song L, Yan X. MicroRNA-329 suppresses angiogenesis by targeting CD146. Mol Cell Biol. 2013, 33(18):3689-99.


From Hong-Xia Duan, 2019-11-25


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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
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