 | Jiuyu Wang, B.S., Associate Professor Member of the Youth Innovation Promotion Association of CAS Chinese Academy of Sciences Key Laboratory of RNA Biology，IBP Structural and functional studies of CRISPR-Cas system E-mail: wangjiuyu(AT)moon.ibp.ac.cn Tel: 010-64884212 Zip code: 100101 |
Biography & Introduction
2007.06-2011.09 B.S., China Agricultural University
2011.07-2015.12 Research Assistant, Key Laboratory of RNA Biology, Institute of Biophysics, CAS
2015.12-present Associate Professor, Key Laboratory of RNA Biology, Institute of Biophysics, CAS
Grants
2018-2020 National Natural Science Foundation of China, Young Scientists Program
Research Interest The clustered regularly interspaced short palindromic repeats (CRISPR), together with CRISPR-associated (Cas) proteins form the microbial adaptive immune system that protects against invading phages and plasmids. The CRISPR-Cas system is a RNA-guided immune system found in nearly half of all bacteria studied, as well as in the majority of archaea. Our research in this area includes the molecular mechanism of spacer acquisition, pre-crRNA processing and RNA-guided DNA/RNA cleavage.
Selected Publications (First author#, Correspondence*)
1. You L, Ma J, Wang J, Artamonova D, Wang M, Liu L, Xiang H, Severinov K, Zhang X*, Wang Y*. Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. Cell 2019, 176, 239–253.
2. Yin M, Wang J, Wang M, Li X, Zhang M, Wu Q*, Wang Y*. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. Cell Res 2017, 27:1365-1377.
3. Liu L#, Li X#, Ma J#, Li Z#, You L, Wang J, Wang M, Zhang X*, Wang Y*. The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. Cell 2017, 170:714-726 e710.
4. Liu L, Li X, Wang J, Wang M, Chen P, Yin M, Li J, Sheng G, Wang Y*. Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities. Cell 2017, 168:121-134 e112.
5. Liu L, Chen P, Wang M, Li X, Wang J, Yin M, Wang Y*. C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism. Mol Cell 2017, 65:310-322.
6. Sheng G, Gogakos T, Wang J, Zhao H, Serganov A, Juranek S, Tuschl T, Patel DJ*, Wang Y*. Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res 2017, 45:9149-9163.
7. Wang J#, Ma J#, Cheng Z, Meng X, You L, Wang M, Zhang X*, Wang Y*. A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses. Cell Res 2016, 26:1165-1168.
8. Wang J#, Li J#, Zhao H, Sheng G, Wang M, Yin M, Wang Y*. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. Cell 2015, 163:840-853.
9. Zhao H, Sheng G, Wang J, Wang M, Bunkoczi G, Gong W, Wei Z, Wang Y*. Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli. Nature 2014, 515:147-150.
10. Sheng G#, Zhao H#, Wang J, Rao Y, Tian W, Swarts DC, van der Oost J, Patel DJ*, Wang Y*. Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A 2014, 111:652-657.
From Jiu-Yu Wang, 2019-10-30
