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  Lu Yang, Ph.D., Associate Prof.
  Member of the Youth Innovation Promotion Association of CAS
  State Key Laboratory of Brain & Cognitive Sciences, IBP
  Cellular basis and molecular regulation of neurogenesisin brain development and brain disease and brain disease
  E-mail: luyang@ibp.ac.cn 
  Zip code: 100101

Biography & Introduction

2007/9-2011/7 China Agricultural University, B.S. in Life Science

2011/9-2017/7 Peking University, Ph.D. in Life Science College

2017/7-2018 Institute of Biophysics, Associate Professor

Research Interest  

oRGcells exist extensively in non-human primates and human cortex, and were thought to be key factors of evolution from non-gyrus to gyrus. We used single-cell RNA-seq to screen the marker genes of oRG cells, and the conditional overexpression of the genes confirmed the genes could promote the proliferation of mouse neural progenitor cells and induce cortical thickening and gyrification in postnatal mice.

Selected Publications

1. Liu, J., W. Liu, L. Yang, Q. Wu, H. Zhang, A. Fang, L. Li, X. Xu, L. Sun, J. Zhang, F. Tang and X. Wang (2017). "The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding."Cell Stem Cell.(Co First Author

2. Dai, H. Q., B. A. Wang, L. Yang, J. J. Chen, G. C. Zhu, M. L. Sun, H. Ge, R. Wang, D. L. Chapman, F. Tang, X. Sun and G. L. Xu (2016). "TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling." Nature 538(7626): 528-532.(Co Fisrt Author

3. Yang, L., Z. C. Ma, C. Cao, Y. H. Zhang, X. L. Wu, R. Lee, B. Q. Hu, L. Wen, H. Ge, Y. Y. Huang, K. Q. Lao and F. C. Tang (2017). "MR-seq: measuring a single cell's transcriptome repeatedly by RNA-seq." Science Bulletin 62(6): 391-398.(Co Fisrt Author

4. Wang, L., J. Zhang, J. Duan, X. Gao, W. Zhu, X. Lu, L. Yang, J. Zhang, G. Li, W. Ci, W. Li, Q. Zhou, N. Aluru, F. Tang, C. He, X. Huang and J. Liu (2014). "Programming and inheritance of parental DNA methylomes in mammals." Cell 157(4): 979-991.

5. Streets, A. M., X. Zhang, C. Cao, Y. Pang, X. Wu, L. Xiong, L. Yang, Y. Fu, L. Zhao, F. Tang and Y. Huang (2014). "Microfluidic single-cell whole-transcriptome sequencing." Proc Natl Acad Sci U S A 111(19): 7048-7053.

6. Yan, L., M. Yang, H. Guo, L. Yang, J. Wu, R. Li, P. Liu, Y. Lian, X. Zheng, J. Yan, J. Huang, M. Li, X. Wu, L. Wen, K. Lao, R. Li, J. Qiao and F. Tang (2013). "Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells." Nat Struct Mol Biol 20(9): 1131-1139.

7. Zhang, R. R., Q. Y. Cui, K. Murai, Y. C. Lim, Z. D. Smith, S. Jin, P. Ye, L. Rosa, Y. K. Lee, H. P. Wu, W. Liu, Z. M. Xu, L. Yang, Y. Q. Ding, F. Tang, A. Meissner, C. Ding, Y. Shi and G. L. Xu (2013). "Tet1 regulates adult hippocampal neurogenesis and cognition." Cell Stem Cell 13(2): 237-245..





From Lu Yang, 2018-02-01


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