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  Shan Shan , Ph.D, Associate Professor
  Member of the Youth Innovation Promotion Association of CAS
  National Laboratory of Biomacromolecules , IBP
  E-mail: shanshan(AT)ibp.ac.cn 
  Tel: +86-10-64889948
  Zip code: 100101

Biography & Introduction

Education & Positions

2007 - 2012  Ph.D., School of Medicine, Tsinghua University,Beijing

2012 - 2016  Assitant Professor, Institute of Biophysics, CAS,Beijing

2017 - Present   Associate Professor, Institute of Biophysics, CAS,Beijing

Research Interest

Dr. Shan is working on the understanding of molecular mechanisms of the remodelling complex (such as SWR1,INO80,SRCAP) catalyzed chromatin histone exchange and their potential application in therapeutics and diagnostics against human dieases. AND also the molecular mechanisms of epgenetic regulations during viruses infection which can help us to understand host-virus interaction, virus evolutional strategy and taxonomy of viruses.
Selected Publications

1. Dai Y*, Zhang A*, Shan S*, Gong Z#, Zhou Z#. Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR. Nature communications ,2018, 9(1): 2123. (* co-first author)
2. Liang X*, Shan S*, Pan L*, Zhao J*, Ranjan A, Wang F, Zhang Z, Huang Y, Feng H, Wei D, Huang L, Liu X, Zhong Q, Lou J, Li G, Wu C#, Zhou Z#. Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. Nature structural & molecular biology, 2016, 23(4): 317-323. (* co-first author)
3. Shan S*#, Min H*, Liu T, Jiang D, Rao Z. Structural insight into dephosphorylation by trehalose 6-phosphate phosphatase (OtsB2) from Mycobacterium tuberculosis. FASEB journal ,2016, 30(12): 3989-3996. (co-first author, corresponding author)
4. Shan S*, Chen X*, Liu T, Zhao H, Rao Z, Lou Z#. Crystal structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis. FASEB journal, 2011, 25(5): 1577-1584. (* co-first author)
5. Shan S, Chen X. Crystallization and preliminary X-ray analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis. Acta crystallographica Section F, 2011, 67(Pt 7): 821-823.
6. Wang Y., Liu S., Sun L., Xu N., Shan S., Wu F., Liang X., Huang Y., Luk E., Wu C., Zhou Z , Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement. PLOS biology, 2019, 17(5): e3000277.
7. Mao Z*, Pan L*, Wang W*, Sun J, Shan S, Dong Q, Liang X, Dai L, Ding X, Chen S, Zhang Z#, Zhu B#, Zhou Z#. Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z. Cell research 2014, 24(4): 389-399.


From Shan Shan, 2019-04-16


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Institute of Biophysics, CAS    Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
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