Han Feng, Ph.D., Associate Professor   　　Member of the Youth Innovation Promotion Association of CAS 　　Pathogen infection and host innate immune defense 　　E-mail: qingfengpa@163.com  　　Tel: +86-10-64887122 　　Zip code: 100101 　　Chinese personal homepage

Biography & Introduction

Education & Positions

2006.09-20011.06 Jilin University, Bachelor of Medicine

20011.09-2016.06 University of Chinese Academy of Sciences, Ph.D

2016.07-2019.12 Institute of Biophysics, CAS Assistant Professor

2020.01-present Institute of Biophysics, CAS Associate Professor

The major research focuses on pathogen infection and host immune response. By means of structural biology (X-ray and cryo-electron microscopy) combined with biochemistry and cell biology, we are trying to explore the molecular mechanisms of pathogen infection and host immunity, as well as design novel drug and biological tools.

Selected Publications

1. Zhu Yalan^#; Gao Ang^#; Zhan Yi; Wang Yong; Feng Han; Liu Songqing; A. Serganov* and Gao Pu*. Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Molecular cell，2019.4.18 74(2): 296~309.

2. Wang Yong^#; Shi Miao; Feng Han; Zhu Yalan; Liu Songqing; Gao Ang*; Gao Pu*. Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE. Cell, 2018.5.17 173(5): 1231~1243.

3. Feng Han^#; Liu Xuehui; Wang Sheng; Fleming Joy; Wang Da-Cheng*; LiuWei*. The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nature Communications, 2017.12.21 8(2242).

4. Feng Han^#; Ding Jingjin^#; Zhu Deyu^#; Liu Xuehui; Xu Xueyong; Zhang Ying; Zang Shanshan; Wang Da-Cheng*; Liu Wei*. Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins. Journal of the American Chemical Society, 2014.10.22 136(42): 14694~14697.

5. Wang Yong^#; Feng Han^#; Zhu Yalan; Gao Pu(*).Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes. Protein & Cell, 2017.03.07 8: 308~312.

6. Feng Han^#; Wang Sheng^#; Guo Ling; Punekar Avinash S.; Ladenstein Rudolf; Wang Da-Cheng*; Liu Wei*. MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction. Protein & Cell, 2016.12 7(12) : 916~920.

7. Feng Han^#; Liu Wei; Wang Da-Cheng*. Purification crystallization and X-ray diffraction analysis of the DNA-binding domain of human heat-shock factor 2. Acta Crystallographica Section F-Structural Biology Communications, 2016.4 72 : 294~299.