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Genetically Encoded Phosphine Ligand for Metalloprotein Design, J. Am. Chem. Soc, 23 Nov 2022

Updated: 2022-11-23

Journal Of The American Chemical Society, 23 November, 2022, DOI:https://doi.org/10.1021/jacs.2c09683


Genetically Encoded Phosphine Ligand for Metalloprotein Design

Hua-Zhen Duan, Cheng Hu, Yue-Lin Li, Shi-Hao Wang, Yan Xia, Xiaohong Liu*, Jiangyun Wang*, and Yong-Xiang Chen*



Phosphine ligands are the most important class of ligands for cross-coupling reactions due to their unique electronic and steric properties. However, metalloproteins generally rely on nitrogen, sulfur, or oxygen ligands. Here, we report the genetic incorporation of P3BF, which contains a biocompatible borane-protected phosphine, into proteins. This step is followed by a straightforward one-pot strategy to perform deboronation and palladium coordination in aqueous and aerobic conditions. The genetically encoded phosphine ligand P3BF should significantly expand our ability to design functional metalloproteins.


Article link:https://pubs.acs.org/doi/10.1021/jacs.2c09683



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