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  Chang Huang, Ph.D, Associate Professor
  Member of the Youth Innovation Promotion Association of CAS
  National Laboratory of Biomacromolecules (NLB)
  E-mail: huangchang@ibp.ac.cn 
  Tel: 010-64888213
  Zip code: 100101

Biography & Introductions

2003-2007 B.S., Biological Sciences, College of Biological Sciences, China Agricultural University, Beijing, China

2007-2012 Ph.D., Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University & National Institute of Biological Sciences, Beijing, China

2012-2014 Postdoc, National Institute of Biological Sciences, Beijing, China

2013-2015 Institute of Biophysics, CAS Associate Professor

2014-2019 Associate Professor, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Research interest

(1) Analysis of the distribution of histone variant H3.3 containing H3-H4 tetramer splitting events at genomewide level by utilizing gene induction system and sequential purification based ChIP-seq technology.

(2) Purification and characterization of histone H3K36me2 methyltransferase Ash1 complex.

Selected Publications

I、Research articles

1. Hou P#, Huang C#, Liu C, Yang N, Yu T, Yin Y, Zhu B, Xu R. Structural insights into stimulation of Ash1’s H3K36 methyltransferase activity by Mrg15 binding. Structure. Published online, 2019 Feb 28. co-first authors)

2. Huang C#, Yang F#, Zhang Z#, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R, Zhu B. Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila. Nat Commun 2017. 21;8(1):1649. (#co-first authors)

3. Huang C#, Zhang Z#, Xu M, Li Y, Li Z, Ma Y, Cai T, Zhu B. 2013. H3.3-H4 tetramer splitting events feature cell-type specific enhancers. PLoS Genet 9: e1003558. (#co-first authors)

4. Yuan W, Xu M, Huang C, Liu N, Chen S, Zhu B. 2011. H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J Biol Chem 286: 7983-7989.

5. Xu M, Long C, Chen X, Huang C, Chen S, Zhu B. 2010. Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science 328: 94-98.


1. Huang C, Zhu B. Roles of H3K36-specific histone methyltransferases in transcription: antagonizing silencing and safeguarding transcription fidelity. Biophys Rep. 2018;4(4):170-177

2. Huang C, Zhu B. 2014. H3.3 turnover: a mechanism to poise chromatin for transcription, or a response to open chromatin? Bioessays 36: 579-584.

3. Huang C, Xu M, Zhu B. 2013. Epigenetic inheritance mediated by histone lysine methylation: maintaining transcriptional states without the precise restoration of marks? Philos Trans R Soc Lond B Biol Sci 368: 20110332.


From Chang Huang, 2019-03-25 update


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