Jun Ma, Ph.D, Associate Professor   　　Member of the Youth Innovation Promotion Association of CAS 　　National Laboratory of Biomacromolecules , IBP 　　Host-virus interaction 　　E-mail: majun(AT)ibp.ac.cn  　　Tel: +86-10-64887082 　　Zip code: 100101 　　Chinese personal homepage

Biography & Introduction

Education & Positions

2003 - 2007, School of Life Sciences, Lanzhou University, B.S.

2008 - 2014, Institute of Biophysics, Chinese Academy of Sciences, Ph.D

2015 - 2017, Institute of Biophysics, Chinese Academy of Sciences, Postdoc

2017 - present, Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

Many viruses are closely related to human diseases and public health. To illustrate the the molecular mechanisms of virus infection and pathogenesis, as well as providing usefull imformation for novel antiviral therapeutics, I would like to focus on the physiological function and structure basis of the proteins encoded by viruses and the interactions between viral and cellular proteins.

Selected Publications

1. You L#, Ma J#, Wang J#, ArtamonovaD, Wang M,Liu L, Xiang H, Severinov K, Zhang X* andWang Y*. Structure studies of the CRISPR-Csm complex reveal mechanism of co-transcriptional interference. Cell, 2019, 176(1-2):239-253.
2. Su X#, Ma J#, Pan X#, Zhao X, Chang W, Liu Z, Zhang X*, Li M*. Antenna arrangement and energy transfer pathways of a green algal photosystem I-LHCI supercomplex. Nature Plants, 2019, 5(3):273-281.
3. Ma J, Zhai Y, Chen M, Zhang K, Chen Q, Pang X*, Sun F*. New interfaces on MiD51 for Drp1 recruitment and regulation. PLoS One, 2019, 14(1):e0211459.
4. Pan X#, Ma J#, Su X#, Cao P, Chang W, Liu Z, Zhang X*, Li M*. Structure of the maize photosystem I supercomplex with light harvesting complexes I and II. Science, 2018, 360(6393):1109-1113.
5. Chen L#, Wang M#, Zhu D#, Sun Z#, Ma J, Wang J, Kong L, Wang S, Liu Z, Wei L, He Y, Wang J*, Zhang X*. Implication for alphavirus host-cell entry and assembly indicated by a 3.5？ resolution cryo-EM structure. Nature Communications, 2018, 9(1):5326.
6. David L, Li Y, Ma J, Garner E, Zhang X, Wu H. Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. Proc Natl Acad Sci U S A, 2018, 115(7):1499-1504. 
7. Su X#, Ma J#, Wei X#, Cao P,# Zhu D, Chang W, Liu Z*, Zhang X*, Li M*. Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex. Science, 2017, 357(6353):815-820. 
8. Liu L#, Li X#, Ma J#, Li Z#, You L, Wang J, Wang M, Zhang X*, Wang Y*. The molecular architecture for RNA-guided RNA cleavage by Cas13a. Cell, 2017, 170(4):714-726. 
9. Yuan Y#, Cao D#, Zhang Y#, Ma J#, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y*, Zhang X*, Gao GF*. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains. Nature Communications, 2017, 8:15092.
10. Wang J#, Ma J#, Cheng Z, Meng X, You L, Wang M, Zhang X*, Wang Y*.A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses.Cell Research, 2016, 26(10):1165-1168.
11. Ma J, Sun F. Expression, purification, crystallization and preliminary crystallographic study of the cytoplasmic domain of the mitochondrial dynamics protein MiD51. Acta Crystallographica Section F, 2014, F70: 596-599.
12. Pang X, Fan J, Zhang Y, Zhang K, Gao B, Ma J, Li J, Deng Y. Zhou Q, Egelman E.H, Hsu VW and Sun F. A PH domain in ACAP1 possesses key features of the BAR domain in promoting membrane curvature. Developmental Cell, 2014, 31(1):73-86.
13. Wang X, Xu F, Liu J, Gao B, Liu Y, Zhai Y, Ma J, Zhang K, Baker T.S, Schulten K, Zheng D, Pang H & Sun F. Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography. PLoS Pathogens, 2013, 9(1): e1003132.
14. Bai M, Pang X, Lou J, Zhou Q, Zhang K, Ma J, Li J, Sun F, Hsu VW. Mechanistic insights into regulated cargo binding by ACAP1. Journal of Biological Chemistry, 2012, 287: 28675-28685.

 

From Jun Ma, 2019-04-22