 | Haibin Wang Ph.D., Associate Professor Member of the Youth Innovation Promotion Association of CAS National Laboratory of Biomacromolecules, IBP E-mail: lincybin@163.com Tel: 010-64888387 Zip code: 100101 |
Biography & Introduction
Education & Positions
2004.09 - 2008.06 Bachelor in Biological Sciences, China Agricultural University
2008.09 - 2013.06 Ph.D. in Biology, China Agricultural University, Beijing, China Joint with National Institute of Biological Sciences, Beijing (NIBS)
2013.07 - 2015.05 Postdoc fellow at National Institute of Biological Sciences, Beijing (NIBS)
2015.06 - 2019.09 Postdoc fellow at Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Germany
2019.10 - present Associate Professor, Institute of Biophysics, Chinese Academy of Sciences
Honors
2013 Excellent oral presentation prize, 3ndChinese C. elegans Meeting, Hefei, China
2013 Monsanto scholarship award for excellent student-research project
2012 Outstanding Student, National Institute of Biological Sciences, Beijing
2011 Excellent Graduate Students of China Agriculture University
Research Interest Macropinocytosis is a process of large-scale, non-selective fluid uptake. Cells extend thin sheets and cups (circular ruffles) from their plasma membrane into the medium, and eventually close them to entrap a droplet of fluid inside a vesicle called macropinosome. Macropinocytosis is important in a range of physiological processes. It allows cells to sample environment and uptake nutrients or capture antigens. Recent studies have also implicated it in cancer and neurodegenerative diseases. we use Dictyostelium as a model system, combining with high content imaging technique, to screen for novel macropinocytosis regulators. We also utilize mammalian system to further elucidate their function.
Selected Publications
1. Wang H, Loerke D, Bruns C, Müller R, Koch PA, Puchkov D, Schultz C, Haucke V. Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway. J Biol Chem., 2020, 295(4):1091-1104.
2. Wang H#; Lo, Wen-Ting#; Haucke, Volker; Phosphoinositide switches in endocytosis and in the endolysosomal system., Curr Opin Cell Bio., 2019, 59: 50-57.
3. Hu J, Cheng S, Wang H, Li X, Liu S, Wu M, Liu Y, Wang X. Distinct roles of two myosins in C.elegans spermatid differentiation. PloS Biol., 2019, Apr 16;17(4).
4. Wang H#, Lo WT#, Zagar A, Gulluni F, Lehmann M, Scapozza L, Haucke V and Vadas O. Autoregulation of class II alpha PI3K activity by its lipid-binding PX-C2 domain module. Mol Cell., 2018, 71(2):343-351.
5. Su Y, Li L, Wang H, Wang X and Zhang Z. All-In-One Azides: Empowered Click Reaction for in vivo Labeling and Imaging of Biomolecules. Chem Commun., 2016, 52(10):2185-8.
6. Cheng S, Wang K, Zou W, Miao R, Huang Y, Wang H, Wang X. PtdIns(4,5) P2 and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance. J Cell Biol., 2015,210(3):485-502.
7. Wang H#, Lu Q*, Cheng S, Wang X, Zhang H. Autophagy activity contributes to programmed cell death in Caenorhabditis elegans. Autophagy., 2013, (12):1975-82.
8. Zhang Y, Wang H and Wang X. Quantification of Cell Corpses, Cell Death Occurrence, Cell Corpse Duration. Bio-protocol., 2013, Vol 3, Iss 9.
9. Huang J#, Wang H#, Chen Y, Wang X, Zhang H. Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance. Development., 2012, 139(24): 4613-22.
10. Zhang Y, Wang H, Kage-Nakadai E, Mitani S, Wang X.C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpseengulfment. Curr Biol., 2012 22(14):1276-84.
From Haibin Wang, 2020-05-21
