Neurotrophins (NTs) engage two types of  cell-surface receptors Trks and p75NTR to play a wide variety of functions in the mammalian nervous system. Recently, Tao Jiang's Group solved the crystal structure of neurotrophin-3 (NT-3) complexed to the ectodomain of p75NTR.  It provides an important model for NTs-p75NTR recognition and signal generation, as well as new insights into coordination between p75NTR and Trks.