1990 – 1994  BS in physics, Jilin University

1994 – 1997  MS in physics, Peking University

1997 – 2000  Ph.D in physics, Institute of theoretical physics, CAS

2000 – 2001  Postdoctoral Fellow, University of Nevada, Las Vegas

2001 – 2005  Postdoctoral Fellow, Georgia Institute of Technology

2005 – 2009  Research Scientist, Georgia Institute of Technology

2009 -            Principal Investigator, Institute of Biophysics, CAS

We use single molecule biophysics techniques and molecular dynamics simulations to study cell mechanobiology and mechano-chemistry of Biomacromolecules. Our researches focus on T-cell immune activation and its regulation. We try to elucidate how immune receptors recognize their ligands and how the recognition signals are transduced across the cell membrane. We also try to develop new strategies for T-cell based immunotherapy for cancers and other immune diseases.

1. Yiran Chen^#, Li Li^#, Jie Lan^#, Yang Cui, Xiaosong Rao, Jing Zhao, Tao Xing, Gaoda Ju, Guangtao Song*, Jizhong Lou*, and Jun Liang*. CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma. Mol Cancer. 2022 Jan 4;21(1):11. doi: 10.1186/s12943-021-01466-9.

2. Juan Fan^#, Jiawei Shi^#, Yong Zhang^#, Junwei Liu, Chenyi An, Huaying Zhu, Peng Wu, Wei Hu, Danmei Yao, Xin Shou, Yibing Xu, Weijia Fang, Zhou Tong, Xue Wen, Jizhong Lou*, Weiwei Yin*, and Wei Chen*. NKG2D sensitively discriminates diverse ligands through selectively mechano-regulated ligand conformational changes. EMBO J. 2022 Dec 17;41(2):e107739. doi: 10.15252/embj.2021107739.

3. Wei Hu^#, Yong Zhang^#, Panyu Fei^#, Tongtong Zhang^#, Danmei Yao^#, Yufei Gao, Jia Liu, Hui Chen, Qiao Lu, Tenny Mudianto, Xinrui Zhang, Chuxuan Xiao, Yang Ye, Qiming Sun, Jing Zhang, Qi Xie, Pei-Hui Wang, Jun Wang*, Zhenhai Li*, Jizhong Lou*, and Wei Chen*. Mechanical activation of spike fosters SARS-CoV-2 viral infection. Cell Res. 2021 Oct;31(10):1047-1060.

4. Hui Chen, Yang Cui, Xuling Han, Wei Hu, Min Sun, Yong Zhang, Pei-Hui Wang, Guangtao Song, Wei Chen*, and Jizhong Lou*. Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA. Cell Res. 2020 Dec; 30(12):1143-1145.. doi: 10.1038/s41422-020-00408-2.

5. Yang Cui, Yangchao Tang, Meng Liang, Qinghua Ji, Yan Zeng, Hui Chen, Jie Lan, Peng Jin, Lei Wang, Guangtao Song*, and Jizhong Lou*. Direct Observation of the Formation of a CRISPR-Cas12a R-loop Complex at the Single-Molecule Level. Chem Commun (Camb). 2020,56 (14), 2123-2126.

6. Wei Hu^#, Yong Zhang^#, Xiaolin Sun^#, Tongtong Zhang, Liling Xu, Hengyi Xie, Zhanguo Li, Wanli Liu*, Jizhong Lou*, and Wei Chen*. FcγRIIB-I232T Polymorphic Change Allosterically Suppresses Ligand Binding. eLife. 2019;8:e46689.

7. Peng Wu^#, Tongtong Zhang^#, Baoyu Liu^#, Panyu Fei^#, Lei Cui^#, Rui Qin, Huaying Zhu, Danmei Yao, Ryan J. Martinez, Wei Hu, Chenyi An, Yong Zhang, Junwei Liu, Jiawei Shi, Juan Fan, Weiwei Yin, Jie Sun, Chun Zhou, Xun Zeng, Chenqi Xu, Jianan Wang, Brian D. Evavold, Cheng Zhu, Wei Chen* and Jizhong Lou*. Mechano-regulation of peptide-MHC class I conformations determines TCR antigen recognition. Mol Cell. 2019 Mar 7;73(5):1015-1027.e7.

8. Song G, Chen H, Sheng G, Wang Y*, Lou J.*. Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome. Biochemistry. 2018 Apr 17;57(15):2179-2183.

9. Zeng Y^#, Cui Y^#, Zhang Y, Zhang Y, Liang M, Chen H, Lan J, Song G*, and Lou J*. The Initiation, Propagation and Dynamics of CRISPR-SpyCas9 R-loop Complex. Nucleic Acids Research. 2018 Jan 9;46(1):350-361.

(From Jizhong Lou, March 31, 2022)