1994 - 1998 B.S., Yantai University

1998 - 2003 Ph.D., Institute of Biophysics, Chinese Academy of Sciences

2003 - 2005 Postdoc. University of Michigan, Ann Arbor

2003 - 2006 Postdoc. Yale University

2006 - 2009 Research Associate, The University of Chicago

2009 - 2023 Professor, Beijing Institute of Genomics, Chinese Academy of Sciences

2023 - Professor, Institute of Biophysics, Chinese Academy of Sciences

1. Epigenetic regulation on gene expression and embryonic development

Epigenetic information regulates gene expression. Abnormal epigenetic regulations can lead to birth failure or birth defects. Our team is interested in establishing new technologies to investigate the spatial epigenome. Then, we are interested in understanding the epigenetic reprogramming during embryonic development. We are also likely to study the mechanism and role of epigenetic information during organogenesis.

2. Clinical translational study of epigenetics in reproductive medicine

Our team has invented the method of "PreImplantation DNA methylation screening (PIMS)". PIMS method has established the first molecular biomarker in evaluating the developmental potential of embryos, which has been used in clinics. Now, we are performing randomized clinical trial of PIMS in multiple assisted reproductive technology (ART) center. Moreover, we are establishing artificial intelligent model to select embryos by PIMS. We also investigate other methods to improve the efficiency of ART practice, and reduce the birth defect rate.

1. Zhenping Chen(陈振平), Maoni Guo(郭毛妮), Lin Zhang(张林), Hao Yu(喻昊), Xinxin Wang(王欣欣), Xinrui Yu, Mingyue Chen(陈明月), Junjie Lv(吕俊杰), Zhisong Chen(陈智松), Changjun Peng(彭长军), Qian Gong(龚倩), Qiao Zhang(张乔), Ru Guo(郭茹), Yiping Huang(黄伊萍), Lei Gao(高磊), Shan Jiang(姜姗), Junmei Wang(王俊梅), Zhihua Zhang(张治华), Jianliang Qian, Jianrong Wang, Jiang Liu(刘江)*, Xuepeng Chen(陈雪鹏)*. Spatially resolved chromatin architectures in mammalian brain tissues. Nature methods. 2026, doi.org/10.1038/s41592-026-03218-3

2. Xun Shan, Yimin Tang, Jinzhou Hu, Mingyuan Bian, Xuelong Yao, Lei Gao*, Jiang Liu*, Spatial 5mC-seq profiling of embryos and decidua after implantation in mammals. Nature methods 2026, 23, 924-934.

3. Shan Jiang, Hao Yu, Ting Zhao, Yao Lu, Xuesong Li, Lei Gao, Jie Mi, Wenzhe Xia, Lanjun Geng, Panpan Li, Mingyue Chen, Mengyao Kang, Jiang Liu*, Yuwen Ke*, A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development. Innovation, 2025, 6, 100767.

4. Chao Ning, Xi Wu, Xudong Zhao, Zongyang Lu, Xuelong Yao, Tao Zhou, Lizhi Yi, Yaoyu Sun, Shuaishuai Wu, Zhenbo Liu, Xingxu Huang*, Lei Gao*, Jiang Liu*, The epigenomic landscapes during prefrontal cortex development and aging in rhesus. National Science Review, 2024, doi.org/10.1093/nsr/nwae213

5. Jianhong Zhan*, Chuangqi Chen, Na Zhang, Shuhuai Zhong, Jiaming Wang, Jinzhou Hu, Jiang Liu*, An artificial intelligence model for embryo selection in preimplantation DNA methylation screening in assisted reproductive technology. Biophysics Reports. 2023, 9(6):352?361

6. Keliang Wu, Dongdong Fan, Han Zhao, ZhenboLiu, Zhenzhen Hou, Wenrong Tao, Guanling Yu, Shenli Yuan, Xiaoxiao Zhu, Mengyao Kang, Yong Tian*, Zi-Jiang Chen*, Jiang Liu* and Lei Gao*. Dynamics of histone acetylation during human early embryogenesis. Cell discovery, 2023, 9, 29.

7. Shan Jiang, Zheng Huang, Yun Li, Chengwei Yu, Hao Yu, Yuwen Ke, Lan Jiang*, and Jiang Liu*, Single-cell chromatin accessibility and transcriptome atlas of mouse embryos. Cell reports. 2023, 42, 112210.

8. Yuan Gao*, Lizhi Yi, Jianhong Zhan, Lijuan Wang, Xuelong Yao, Junhao Yan, Sijing Jian, Lei Gao, Mamadboqirova Farangez, Ming Gao, Yang Zou, Xuan Gao, Keliang Wu, Jiang Liu*, and Zi-Jiang Chen*. A clinical study of preimplantation DNA methylation screening in assisted reproductive technology. Cell Research. 2023, May; 33: 483-485

9. Xuelong Yao, Zongyang Lu, Zhanying Feng, Lei Gao, Xin Zhou, Min Li, Suijuan Zhong, Qian Wu, Zhenbo Liu , Haofeng Zhang, Zeyuan Liu, Lizhi Yi, Tao Zhou, Xudong Zhao, Jun Zhang, Yong Wang, Xingxu Huang*, Xiaoqun Wang* & Jiang Liu*. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human. Nature Communications, 2022,13:3883

10. Xinxin Wang, Xin Ma, Gaobo Wei, Weirui Ma, Zhen Zhang, Xuepeng Chen, Lei Gao, Zhenbo Liu, Yue Yuan, Lizhi Yi, Jun Wang, Toshinobu Tokumoto, Junjiu Huang, Dahua Chen*, Jian Zhang*, Jiang Liu*. The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish. Genomics Proteomics & Bioinformatics, 2021, 19(1):48-63

11. Xuepeng Chen, Yuwen Ke, Keliang Wu, Han Zhao, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao, Zhenzhen Hou, Hui Liu, Jiang Liu*, Zi-Jiang Chen*. Key role for CTCF in establishing chromatin structure in human embryos. Nature, 2019, 576：306-310

12. Xiaocui Xu, Guoqiang Li, Congru Li, Jing Zhang, Qiang Wang, David K. Simmons, Xuepeng Chen, Naveen Wijesena, Wei Zhu, Zhanyang Wang, guoNeelakanteswar Aluru, Paola Oliveri, Yong E. Zhang, Mark Q. Martindale and Jiang Liu*, Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis. National Science Review, 2019, doi: 10.1093/nsr/nwz064

13. Lei Gao, Keliang Wu, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Jianqiao Liu*, Zi-Jiang Chen*, and Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. Cell, 2018, 173, 248-259

14. Congru Li, Yong Fan, Guoqiang Li, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Yang Yu*, Jiang Liu*. DNA methylation reprogramming of functional elements during mammalian embryonic development. Cell Discovery, 2018, 4:41

15. Yuwen Ke, Yanan Xu, Xuepeng Chen, Songjie Feng, Zhenbo Liu, Yaoyu Sun, Xuelong Yao, Fangzhen Li, Wei Zhu, Lei Gao, Haojie Chen, Zhenhai Du, Xie Wei, Xiaocui Xu, Xingxu Huang*, Jiang Liu*. 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis, Cell, 2017, 170, Jul 13;170(2):367-381.e20

16. Guoqiang Li, Yang Yu, Yong Fan, Congru Li, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao*, Jiang Liu*, Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology, Journal of Genetics and Genomics, 2017, Oct 20; 44 (10): 475-481.

17. Ke Chen, Jing Zhang, Zhongqiang Guo, Qin Ma, Zhengzheng Xu, Yuanyuan Zhou, Zhiying Xu, Zhongwu Li, Yiqiang Liu, Xiongjun Ye, Xuesong Li, Bifeng Yuan, Yuwen Ke, Chuan He, Liqun Zhou*, Jiang Liu* and Weimin Ci*. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer, Cell Research, 2016, Jan; 26(1):103-18

18. Yunfang Wang*, Jinhua Qin, Shuyong Wang, Wencheng Zhang, Jialei Duan, Jing Zhang, Xin Wang, Fang Yan, Mingyang Chang, Xiaofang Liu, Bo Feng, Jiang Liu*, Xuetao Pei*, Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules, Cell Stem Cell, 2016, Oct 6; 19 (4); 449-461, * co-senior author

19. Zhong-Qiang Guo, Tong Zheng, Baoen Chen, Cheng Luo, Sisheng Ouyang, Shouzhe Gong, Jiafei Li, Liu-Liang Mao, Fulin Lian, Yong Yang, Yue Huang, Li Li, Jing Lu, Bidong Zhang, Luming Zhou, Hong Ding, Zhiwei Gao, Liqun Zhou, Guoqiang Li, Ran Zhou, Ke Chen, Jingqiu Liu, Yi Wen, Likun Gong, Yuwen Ke, Shang-Dong Yang, Xiao-Bo Qiu, Naixia Zhang, Jin Ren, Dafang Zhong, Cai-Guang Yang,* Jiang Liu,* and Hualiang Jiang*. Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer, Cancer Cell, 2016, 30(3), 474-484 (highlighted by Nature Reviews Urology)

20. Lu Wang, Jun Zhang, Jialei Duan, Xinxing Gao, Wei Zhu, Xingyu Lu, Lu Yang, Jing Zhang, Guoqiang Li, Weimin Ci, Wei Li, Qi Zhou, Neel Aluru, Fuchou Tang, Chuan He, Xingxu Huang*, Jiang Liu*, Programming and inheritance of parental DNA methylomes in mammals, Cell, 2014, 157(4),979-991

21. Guoqiang Li, Weimin Ci, Subhradip Karmakar, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Erin E. Mowers, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman, Jiang Liu*, Kevin P. White*, SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer, Cancer Cell, 2014, 25(4), 455-468.

22. Lan Jiang, Jing Zhang, Jing-Jing Wang, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci*, Jiang Liu*. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos, Cell, 2013, 153(4), 773-84, (Cover story，highlighted by Cell, Nature Review Genetics）

23. Jiang Liu^#, Murad Ghanim^#, Lei Xue^#, Ivan Iossifov, Cesar Angeletti, Sujun Hua, Nicolas Negre, Michael Ludwig, Thomas Stricker, Hikmat A. Al-Ahmadie, Maria Tretiakova, Robert L. Camp, Montse Perera-Alberto, David L. Rimm, Tian Xu, Andrey Rzhetsky and Kevin P. White. 2009. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer, Science, 2009, 323(5918):1218-1222

(From Jiang Liu, October 26, 2026)