Junhua Lv, Ph.D., Prof.
-
Principal Investigator
State Key Laboratory of Epigenetic Regulation and Intervention, IBP
Research Interests: Stem cell function and lineage differentiation, disease pathogenesis and drug resistance
Email: lvjh@ibp.ac.cn
Tel: 010-64888671
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
2005 - 2009 B.S., Shandong Agricultural University
2009 - 2012 M.S., Shandong Agricultural University
2012 - 2017 Ph.D., Institute of Zoology, Chinese Academy of Sciences
2017 - 2018 Postdoc Fellow, City of Hope
2018 - 2023 Postdoc Fellow, UT Southwestern Medical Center
2023 - 2025 Scientist, St. Jude Children's Research Hospital
2025 - Principle Investigator, Institute of Biophysics, Chinese Academy of Sciences
- Awards
- Membership in Academies & Societies
- Research Interests
Our group conducts systematic basic research on hematopoietic development, disease pathogenesis, and therapeutic interventions. The main research areas include:
1. Regulatory mechanisms of hematopoietic stem cell function and lineage differentiation;
2. Pathogenic mechanisms underlying the initiation and progression of hematologic malignancies, and the discovery of novel diagnostic biomarkers and therapeutic targets;
3. Mechanisms of drug resistance and development of new targeted therapeutic strategies.
- Grants
- Selected Publications
Selected Publications:
1. Lyu J, Liu Y, Liu N, Vu H, Cai F, Cao H, Kaphle P, Wu Z, Botten GA, Zhang Y, Wang J, Achyutuni S, Gao X, Iacobucci I, Mullighan CG, Chun SS, Ni M, DeBerardinis RJ, Xu J*. CD44-Mediated Metabolic Rewiring is A Targetable Dependency of IDH-Mutant Leukemia. Blood. 2025.145(14):1553-1567.
2. Lyu J#, Gu Z#, Zhang Y#, Vu H, Lechauve C, Cai F, Cao H, Keith J, Brancaleoni V, Granata F, Motta I, Cappellini MD, Huang LJS, DeBerardinis RJ, Weiss MJ, Ni M*, Xu J*. A Glutamine Metabolic Switch Supports Erythropoiesis. Science. 2024 Nov 15;386(6723):eadh9215.
3. Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J*. Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance. Cancer Discov. 2023. 13(1):170-193
4. Lv J#, Zhang Y#, Gao S#, Zhang C#, Chen Y#, Li W, Yang YG, Zhou Q, Liu F*. Endothelial-specific m6A Modulates Mouse Hematopoietic Stem and Progenitor Cell Development via Notch Signaling. Cell Res. 2018. 28(2):249-252.
5. Lv J#, Wang L#, Gao Y, Ding Y, Liu F*. 5-hydroxytryptamine Synthesized in the Aorta-Gonad-Mesonephros Regulates Hematopoietic Stem and Progenitor Cell Survival. J Exp Med. 2017. 214(2):529-545.
Invited Reviews/Comments:
1. Lyu J, Ni M, Weiss MJ, Xu J*. Metabolic Regulation of Erythrocyte Development and Disorders. Exp Hematol. 2024 Jan 16:104153.
2. Lyu J, Xu J*. Context matters: role of ATF4 in hematopoiesis. Blood. 2024 Aug 15;144(7):684-686.
3. Lv J, Liu F*. The Role of Serotonin Beyond the Central Nervous System during Embryogenesis. Front Cell Neurosci. 2017. 11:74.
(From Junhua Lv, September 30, 2025)