Kelong Fan, Ph.D, Prof.
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Principal Investigator
State Key Laboratory of Biomacromolecules, IBP
Research Interests: Biomedical Applications of Nanozymes
Email: fankelong@ibp.ac.cn
Tel: +86-10-64888280
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
Education Sep, 2009 - Jul, 2014 Institute of Biophysics, Chinese Academy of Sciences PhD., Cell Biology Thesis topic: Ferritin nanoparticles: novel property and applications for tumor detection and therapy Work Experience Aug, 2019 - present Institute of Biophysics, Chinese Academy of Sciences 15 Datun Road, Beijing, China Professor Conducting researches on nanozyme, ferritin and others and teaching students Aug, 2014 - Jul, 2019 Institute of Biophysics, Chinese Academy of Sciences 15 Datun Road, Beijing, China Associate Professor Conducting researches on nanozyme, ferritin and others and teaching students Aug, 2014 - Jan, 2018 Institute of Biophysics, Chinese Academy of Sciences 15 Datun Road, Beijing, China Postdoctor Conducting researches
- Awards
2022-2025 Highly-Cited Researcher, Clarivate
2021-2026 World's Top 2% Scientists, Stanford University
2024 Highly Ranked Scholar- Prior Five years in All Fields of Scholarly Endeavor, ScholarGPS
2023 Excellent member of Youth Innovation Promotion Association, Chinese Academy of Sciences;
2023 VCANBIO Award for Innovations and Breakthroughs in Life Science and Medicine;
2023 High-level Talent, Phoenix Program of Chaoyang, Beijing;
2022 First Prize of "Invention, Entrepreneurship and Innovation", China Invention Association;
2019 Bei Shizhang Young Biophysicist Award;
2019 Member of Young Innovation Promotion Society, Chinese Academy of Sciences;
2019 Good Youth in Innovation and Entrepreneurship, National Innovation and Entrepreneurship Program;
- Membership in Academies & Societies
- Research Interests
1. Rational Design of High-Activity Nanozymes and Structure-Activity Relationship Studies of Nanozymes. The first to propose a new concept for mimicking natural enzyme active centers, biomimetic design, and optimization of nanozymes, enabling the design of high-activity nanozymes that surpass natural enzymes.
2. Ferritin Nanozymes and Studies on Tumor Diagnosis and Catalytic Therapy. The first to discover that ferritin is a novel ligand of TfR1, capable of recognizing tumor tissues and crossing the blood brain barrier (BBB). We designed ferritin nanozyme probes, created a new method for tumor immunodiagnosis, and developed new strategies for nanozyme-mediated tumor catalytic therapy and a new therapeutic approach for malignant cerebral malaria.
3. Ferritin-Based Nano-Drug Delivery Carriers. The first to discover a temperature-sensitive drug channel in ferritin, developed ferritin-based nano-drug delivery carriers, achieved a breakthrough in nucleic acid drug loading, and promoted the industrialization of ferritin-based drug carriers.
- Grants
- Selected Publications
1. Ruofei Zhang, Hanqing Zhao, Sijie Zhang, Xiyun Yan*, Kelong Fan*. Standardized assays for evaluating superoxide dismutase-like and catalase-like activities of nanozymes. Nature Protocols, 2026.
2. Xiaoyong Zhang, Hang Yu, Kai Zhu, Yao Xiao, Yuxuan Gong, Dandan Che, Wanyi Chen, Guoxing You, Xiyun Yan, Quan Wang*, Kelong Fan*, Hong Zhou*, Gan Chen*. Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds. Nature Communications, 2026, 17:6935.
3. Shuai Zhang, Yiliang Jin, Yaxin Hou, Guoheng Tang, Zhuoran Wang, Xuehui Chen*, Xiyun Yan*, Kelong Fan*. Bioengineered ferritin-based lysosome-targeting chimera platform for tumor-targeted therapy. Nature Communications, 2026, 17:3706.
4. Yixin Yu, Ran Xu, Xuetong Wu, Bilian Wang*, Mingzhen Zhang*, Kelong Fan*. A Spin-Engineered Nanozyme Overcomes the Activity-Selectivity Trade-Off for Sustainable Adhesive Production From Lignin Biomass Conversion. Advanced Materials, 2026, 38(7):e17928.
5. Qihang Ding, Kai Liao, Kunxiu Zhang, Mingzhen Zhang*, Ling Mei*, Kelong Fan*. Beyond Enzyme Mimics: Engineering Photo-Responsive Nanozymes for Therapeutic Innovation. Advanced Materials, 2025, 38(3):e10661.
6. Haolun Gu, Jingqi Li, Pengyu Dai, Tiedong Sun*, Chunxia Chen*, Zhong Guo*, Kelong Fan*, Polyphenol Oxidase-Like Nanozymes. Advanced Materials, 2025, e09346.
7. Yaxin Hou, Guoheng Tang, Qizhi Wang, Meng Zhou, Ran Xu, Xuehui Chen, Guizhi Shi, Zhuoran Wang, Xiyun Yan*, Jie Zhuang*, Kelong Fan*. Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations. Signal Transduction and Targeted Therapy, 2025, 10(1): 212.
8. Ruofei Zhang, Xiyun Yan, Lizeng Gao*, Kelong Fan*. Nanozymes expanding the boundaries of biocatalysis, Nature Communications, 2025, 16(1): 6817.
9. Yiliang Jin, Baoli Zhang, Jianru Li, Zhenxi Guo, Chen Zhang, Xuehui Chen, Long Ma, Zhuoran Wang, Haiyin Yang, Yong Li, Yuhua Weng, Yuanyu Huang, Xiyun Yan*, Kelong Fan*, Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma. Science Advances. 2025, 11(8): eadr9266.
10. Long Ma, Zimo Liang, Yinyin Hou, Ruofei Zhang, Kelong Fan*, Xiyun Yan*，Nanozymes and Their Potential Roles in the rigin of Life. Advanced Materials. 2025, 37 (6): 2412211.
11. Zheng Li, Xiaowan Fan, Ying Liu, Muxin Yue, Tingting Wu, Xing Wang*, Wei Jiang*, Kelong Fan*, Engineering Mild-Photothermal Responsive and NO Donor Prussian Blue Nanozymes Using Mild Synthesis for Inflammation Regulation and Bacterial Eradication in Periodontal Disease. Advanced Materials. 2025, 37 (6): 2409840.
12. Ruofei Zhang, Yanfang Shen, Xiaoying Zhou, Jianru Li, Hanqing Zhao, Zixia Zhang, Jun Zhao, Hongjun Jin, Shuanshuan Guo, Hui Ding, Guohui Nie, Zhe Zhang*, Ying Wang*, Xiyun Yan*, Kelong Fan*, Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization. Nature Communications, 2025, 16(1): 890.
13. Ruofei Zhang, Bing Jiang, Kelong Fan*, Lizeng Gao*, Xiyun Yan*. Designing nanozymes for in vivo applications. Nature Reviews Bioengineering. 2024, 2(10): 849-868.
14. Jingqi Li, Xinda Cai, Peng Jiang, Huayuan Wang, Shiwei Zhang, Tiedong Sun*, Chunxia Chen*, Kelong Fan*. Co-based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences. Advanced Materials. 2024, 36(8): 2307337.
15. Daji Wang*, Jie Wang*, Xuejiao J. Gao, Hui Ding, Ming Yang, Zhiheng He, Jiaying Xie, Zixia Zhang, Haibing Huang, Guohui Nie*, Xiyun Yan*, Kelong Fan*. Employing Noble Metal-Porphyrins to Engineer Robust and Highly Active Single-Atom Nanozymes for Targeted Catalytic Therapy in Nasopharyngeal Carcinoma. Advanced Materials. 2024, 36(7): 2310033.
16. Zhuoran Wang, Yue Zhao, Yaxin Hou, Guoheng Tang, Ruofei Zhang, Yili Yang, Xiyun Yan*, Kelong Fan*. A Thrombin-Activated Peptide-Templated Nanozyme for Remedying Ischemic Stroke via Thrombolytic and Neuroprotective Actions. Advanced Materials. 2024, 36 (10): 2210144. (Recommended in Faculty Opinions)（ESI highly cited paper）
17. Xiangqin Meng, Huizhen Fan, Lei Chen, Jiuyang He, Chaoyi Hong, Jiaying Xie, Yinyin Hou, Kaidi Wang, Xingfa Gao, Lizeng Gao, Xiyun Yan*, Kelong Fan*. Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy. Nature Communications. 2024, 15: 1626.
18. Long Ma, Jia-Jia Zheng, Ning Zhou, Ruofei Zhang, Long Fang, Yili Yang, Xingfa Gao, Chunying Chen, Xiyun Yan*, Kelong Fan*. A natural biogenic nanozyme for scavenging superoxide radicals. Nature Communications. 2024,15: 233. (Featured Article selected by Editors of NC).
19. Wei Jiang, Qing Li*, Ruofei Zhang, Jianru Li, Qianyu Lin, Jingyun Li, Xinyao Zhou, Xiyun Yan*, Kelong Fan*. Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson's disease. Nature Communications, 2023, 14: 8137.
20. Huizhen Fan, Jiajia Zheng, Jiaying Xie, Juewen Liu, Xingfa Gao, Xiyun Yan, Kelong Fan, Lizeng Gao*, Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay, Advanced Materials. 2023, 36(10): 2300387.
21. Yongjuan Li, Yu Zhang, Ya Dong, Ozioma Udochukwu Akakuru, Xiaohan Yao, Jinmeng Yi, Xinyan Li, Linlin Wang, Xiaohan Lou, Baoyu Zhu, Kelong Fan*, Zhihai Qin*. Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme-Mediated Catalytic/Starvation/Mild-Temperature Photothermal Therapy. Advanced Materials. 2023, 35(22): 2210464.
22. Wenhui Gao, Jiuyang He, Lei Chen, Xiangqin Meng, Yana Ma, Liangliang Cheng, Kangsheng Tu, Xingfa Gao, Cui Liu*, Mingzhen Zhang*, Kelong Fan*, Dai-Wen Pang*, Xiyun Yan*. Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme. Nature Communications. 2023, 14: 160. (Featured Article Selected by Editors of NC)（ESI highly cited paper）
23. Ruofei Zhang#, Bai Xue#, Yanhong Tao#, Hanqing Zhao, Zixia Zhang, Xiaonan Wang, Xinyao Zhou, Bing Jiang, Zhenglin Yang*, Xiyun Yan*, and Kelong Fan*. Edge-site Engineering of Defective Fe-N4 nanozymes with Boosted Catalase-like Performance for Retinal Vasculopathies. Advanced Materials. 2022, 34(39): 2205324.（ESI highly cited paper）
(From Kelong Fan, October 22, 2026)