Tao Jiang, Ph.D, Prof.
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Principal Investigator
State Key Laboratory of Biomacromolecules, IBP
Research Interests: Structural and functional analysis of biomacromolecules and structure- based drug discovery
Email: tjiang@ibp.ac.cn
Tel: 010-64888510
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
1987 - 1991 Bachelor of Chemistry, Xiamen University
1995 - 1998 PhD. of Biophysics, Institute of Biophysics, CAS
1999 - 2004 Associate professor, Institute of Biophysics, CAS
2004 - Professor, Institute of Biophysics, CAS
- Awards
- Membership in Academies & Societies
- Research Interests
1. Structural and functional research on neurodegenerative diseases and drug development.
2. Development of gene editing tools and their applications in disease surveillance.
3. Structural and functional studies on DNA damage response and investigation of its pathological implications.
4. Studies of key enzymes in anabolism related to natural bioactive small molecules.
- Grants
- Selected Publications
1. Huo YG*, Zhao HS, Dong QH, Jiang T*. (2023) Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat. Microbiol. 8, 522-532.
2. Li HL, Huo YG, He X, Yao LP, Zhang H, Cui YQ, Xiao HJ, Xie WX, Zhang DJ, Wang Y, Zhang S, Tu HX, Cheng YW, Guo YS, Cao XT, Zhu YF, Jiang T, Guo XJ*, Qin Y*, Sha JH*. (2022) A male germ-cell-specific ribosome controls male fertility. Nature. 612(7941):725-731.
3. Xiao YM, Chen JY, Hou XC, Wang HW, Zhang KD, Xu SJ, Jiang T, Huo YG*, Zhang FY*, Gu LC*. (2025) A NanoLock-enabled, Craspase-based strategy for highly sensitive RNA detection. Nucleic Acids Res. 53(17): gkaf907.
4. Tong YR, Ma XL, Hu TY, Chen K, Cui GH, Su P, Xu HF, Gao W*, Jiang T*, Huang LQ*. (2022) Structural and mechanisticinsights intothe precise product synthesis by a bifunctional miltiradiene synthase. Plant Biotechnol J. 21(1):165-175.
5. Huo YG, Li T, Wang N, Dong QH, Wang XX, Jiang T*. (2018) Cryo-EM structure of Type III-A CRISPR effector complex. Cell Res. 28(12):1195-1197.
6. Xu M, Yang X, Yang XA, Zhou L, Liu TZ, Fan Z*, Jiang T*. (2016) Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system. Protein Cell. 7 (6):403-16.
7. Wang TY, Sun HL, Cheng F, Zhang XE, Bi LJ*, Jiang T*. (2013) Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5'exonuclease. Nucleic Acids Res. 41 (15): 7556-7565.
8. Tong Q, Wang F, Zhou HZ, Sun HL, Song H, Shu YY, Gong Y, Zhang WT, Cai TX, Yang FQ, Tang J, Jiang T*. (2012) Structural and functional insights into lipid-bound nerve growth factors. FASEB J. 26, 3811-3821.
9. Gong Y, Zhu D, Ding J, Dou CN, Ren X, Gu L, Jiang T*, Wang DC*. (2011) Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Nat Struct Mol Biol. 18, 1297-1299.
10. Tang L, Bai L, Wang WH, Jiang T*. (2010) Crystal structure of the carnitine transporter and insights into the antiport mechanism. Nat Struct Mol Biol. 17, 492-496.
11. Xu M, Bai L, Gong Y, Xie W, Hang HY*, Jiang T*. (2009) Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex. J Biol Chem. 284, 20457-20461.
12. Gong Y, Cao P, Yu HJ, Jiang T*. (2008) Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature. 454, 789-793.
13. Tang L, Li MH, Cao P, Wang F, Chang WR, Bach S, Reinhardt J, Ferandin Y, Galons H, Wan Y, Gray N, Meijer L, Jiang T*, Liang DC*. (2005) Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem. 280, 31220-31229.
14. Li MH, Kwok F, Chang WR, Lau CK, Zhang JP, Lo SC, Jiang T*, Liang DC*. (2002) Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily. J Biol Chem. 277, 46385-46390.
(From Tao Jiang, November 20, 2025)