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Dongpeng Wang, Ph.D., Prof.

Principal Investigator
Key Laboratory of Epigenetic Regulation and Intervention, IBP


Research Interests: DNA damage and repair, Epigenetics.


Email: wangd@ibp.ac.cn


Tel: 010-64888570


Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China


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Biography

2010 - 2014  B.S., School of Life Sciences, Hubei University

2014 - 2019  Ph.D., Institute of Biophysics, Chinese Academy of Sciences

2020 - 2024  Postdoctoral Fellow, National Cancer Institute, NIH

2024 -           Institute of Biophysics, CAS, Principle Investigator

Awards
Membership in Academies & Societies
Research Interests

Genomic instability is a key driver of neurodegenerative diseases, cancer, and immune-inflammatory disorders. DNA damage triggers repair mechanisms and activates intricate cellular signaling pathways that ultimately dictate cell fate-repair, apoptosis, or senescence.

Our main research topics include:

1. DNA Repair with epigenetic regulation.

2. Functional mechanisms of DNA damage in postmitotic cells like neuron and macrophage.

3. The role of non-coding RNAs and other epigenetic factors in DNA damage and repair.

Grants
Selected Publications

1. Lihui Liu#; Ziyang Liu#; Qinghua Liu#; Wei Wu#; Peng Lin#; Xing Liu#; Yuechuan Zhang; Dongpeng Wang; Briana C. Prager; Ryan C. Gimple; Jichuan Yu; Weixi Zhao; Qiulian Wu; Wei Zhang; Erzhong Wu; Xiaomin Chen; Jianjun Luo; Jeremy N. Rich*; Qi Xie*; Tao Jiang*; Runsheng Chen*; LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O methylation, Nature Communications, 2023, 14(1)

2. Dongpeng Wang#; Wei Wu#; Elsa Callen#; Raphael Pavani; Nicholas Zolnerowich; Srikanth Kodali; Dali Zong; Nancy Wong; Santiago Noriega; William J. Nathan; Gabriel Matos-Rodrigues; Raj Chari; Michael J. Kruhlak; Ferenc Livak; Michael Ward; Keith Caldecott; Bruno Di Stefano; André Nussenzweig*; Active DNA demethylation promotes cell fate specification and the DNA damage response, Science, 2022, 378(6623): 983-989

3. Chong Zhang#; Dongpeng Wang#; Yajing Hao#; Shuheng Wu; Jianjun Luo; Yuanchao Xue; Di Wang; Guohong Li; Lihui Liu; Changwei Shao; Huiyan Li; Jinfeng Yuan; Maoxiang Zhu; Xiang-Dong Fu*; Xiao Yang*; Runsheng Chen*; Yan Teng* ; LncRNA CCTT-mediated RNA-DNA and RNA-protein interactionsfacilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly, Molecular Cell, 2022, 82(21): 4018-4032.e9

4. Xiaoli Cui; Ruijin Zhang; Ye Yang; Erzhong Wu; Yiheng Tang; Zhihua Zhao; Chao Li; Lei Yang; Xueyi Teng; Yanzhen Ye; Ya Cui; Feng Xu; Zewen Su; Dongpeng Wang; Dongdong Zhang; Yan Yang; Jianyuan Sun; Jianjun Luo*; Shuli Zhang*; Runsheng Chen*; Jianzhong Jeff Xi*; Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory, Cell Reports, 2022, 38(8): 110398

5. Wei Wu#; Sarah E. Hill#; William J. Nathan#; Jacob Paiano; Elsa Callen; Dongpeng Wang; Kenta Shinoda; Niek van Wietmarschen; Jennifer M. Colón-Mercado; Dali Zong; Raffaella De Pace; Han-Yu Shih; Steve Coon; Maia Parsadanian; Raphael Pavani; Hana Hanzlikova; Solji Park; Seol Kyoung Jung; Peter J. McHugh; Andres Canela; Chongyi Chen; Rafael Casellas; Keith W. Caldecott*; Michael E. Ward*; André Nussenzweig* ; Neuronal enhancers are hotspots for DNA single-strand break repair, Nature, 2021, 593(7859): 440-444

6. Yajing Hao#; Dongpeng Wang#; Shuheng Wu; Xiao Li; Changwei Shao; Peng Zhang; Jia-Yu Chen; DoHwan Lim; XiangDong Fu*; Runsheng Chen*; Shunmin He*; Active retrotransposons help maintain pericentromeric heterochromatin required for faithful cell division, Genome Research, 2020,30(11): 1570-1582

7. Shuheng Wu#; Erzhong Wu#; Dongpeng Wang#; Yiwei Niu; Haiyan Yue; Dongdong Zhang; Jianjun Luo*; Runsheng Chen* ; LncRNA HRCEG, regulated by HDAC1, inhibits cells proliferation and epithelial mesenchymal-transition in gastric cancer, Cancer genetics, 2020, 241: 25-33

8. Yanying Wang; Pingping Zhu; Jianjun Luo; Jing Wang; Zhiwei Liu; Wei Wu; Ying Du; Buqing Ye; Dongpeng Wang; Lei He; Weizheng Ren; Jianyi Wang; Xianhui Sun; Runsheng Chen*; Yong Tian*; Zusen Fan*; LncRNA HAND2‐AS1 promotes liver cancer stem cell self‐renewal via BMP signaling, EMBO Journal, 2019, 38(17): e101110-e101110

9. Ya Cui #; Xiaowei Chen#; Yiwei Niu #; Dongpeng Wang; Huaxia Luo; Zhen Fan; Dan Wang; Wei Wu; Xueyi Teng; Shunmin He; Jianjun Luo; Runsheng Chen*; Dynamic-BM: multispecies Dynamic BodyMap database from temporal RNA-seq data, BRIEFINGS IN BIOINFORMATICS, 2018, 6(19): 1302-1309

10. Bao Zhang#; Dongpeng Wang# ; Jing Wu#; Jun Tang; Weixiong Chen; Xiaomin Chen; Dongdong Zhang; Yanming Deng; Mingzhou Guo; Yuejian Wang*; Jianjun Luo*; Runsheng Chen*; Expression Profiling and Functional Prediction of Long Noncoding RNAs in Nasopharyngeal Nonkeratinizing Carcinoma, DISCOVERY MEDICINE, 2016, 116(21): 239-250

 

(From Dongpeng Wang, September 11, 2024)

 

Contact Us

Tel: 010-64889872

E-Mail: webadmin@ibp.ac.cn

Address: No 15 Datun Road, Chaoyang District, Beijing

Postcode: 100101