Pengyuan Yang, Ph.D, Prof.
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Principal Investigator
Chinese Academy of Sciences Key Laboratory of Infection and Immunity, IBP
Research Interests: HBV infection and associated tumor immune microenvironment
Email: pyyang@ibp.ac.cn
Tel: 010-64886041
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
1995 - 1999 Second Military Medical University, B.S.
1999 - 2004 Second Military Medical University, Ph.D.
2004 - 2008 Second Military Medical University, Lecturer/Postdoc
2009 - 2014 Duke University Medical School, USA, Postdoc
2014 - Principle Investigator, Institute of Biophysics, Beijing, China
- Awards
- Membership in Academies & Societies
- Research Interests
1. Mechanism of HBV-induced carcinogenesis
2. Host interactions with HBV
3. Virus-derived antigens and recognition
4. Inflammation-Cancer linkage
- Grants
- Selected Publications
1. Gao Y#, You M#, Fu J#, Tian M, Zhong X, Du C, Hong Z, Zhu Z, Liu J, Markowitz GJ, Wang FS*, Yang P*. Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HBV-associated HCC. Journal of Hepatology. 2022 Jan;76(1):148-159. doi: 10.1016/j.jhep.2021.08.029.
2. You M#, Chen L*#, Zhang D#, Zhao P#, Chen Z, Qin EQ, Gao Y, Davis MM*, Yang P*. Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19. Nat Cell Biol. 2021 Jun; 23(6): 620-630. doi: 10.1038/s41556-021-00690-1.
3. Zhang C#, Gao Y#, Du C#, Markowitz GJ#, Fu J#, Zhang Z, Liu C, Qin W, Wang H, Wang F*, Yang P*. Hepatitis B-induced IL-8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation. Cancer Res. 2021 May 1; 81(9): 2386-2398. doi: 10.1158/0008-5472.CAN-20-3453.
4. Qiu W, Zhang Q, Zhang R, Lu Y, Wang X, Tian H, Yang Y, Gu Z, Gao Y, Yang X, Cui G, Sun BF, Peng Y, Deng H, Peng H, Yang A, Yang YG*, Yang P*. N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA. Nat Commun. 2021 Mar 11;12(1):1582. doi: 10.1038/s41467-021-21904-y.
5. Yang B#, Li B#, Jia L, Jiang Y, Wang X, Jiang S, Du S, Ji X*, Yang P*. 3D landscape of Hepatitis B virus interactions with human chromatins. Cell Discov. 2020 Dec 29;6(1):95. doi: 10.1038 /s41421-020-00218-1.
6. Jia L, Gao Y, He Y, Hooper JD*, Yang P*. HBV induced hepatocellular carcinoma and related potential immunotherapy (Invited Review). Pharmacol Res. 2020 Sep; 159: 104992. doi: 10.1016 /j.phrs.2020. 104992.
7. Qiu W, Wang B, Gao Y, Tian Y, Tian M, Chen Y, Xu L, Yao TP, Li P, Yang P*. Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma. Hepatology. 2020 Jun;71(6):1967-1987. doi: 10.1002/hep.30960. (Cover story)
8. Gao Y#, Fan X#, Li N#, Du C, Yang B, Qin W, Fu J, Markowitz GJ, Wang H, Ma J*, Cheng S*, Yang P*. CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma. Pharmacol Res. 2020 Jul; 157: 104800. doi: 10.1016 /j.phrs.2020. 104800.
9. Tian Y#, Yang B#, Qiu W, Hao Y, Zhang Z, Yang B, Li N, Cheng S, Lin Z, Rui YC, Cheung OKW, Yang W, Wu WKK, Cheung YS, Lai PBS, Luo J, Sung JJY, Chen R, Wang HY, Cheng ASL*, Yang P*. ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. Nat Commun. 2019 Jul 29;10(1):3391. doi: 10.1038/s41467-019-11274-x.
(From Pengyuan Yang, May 19, 2022)