Chinese Academy of
Sciences Protein
Science core facility
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IBP Seminar：Multiple functions of the Origin Recognition Complex in Drosophila,Thursday, October 23, 2008, 9：00 a.m. |
| Author: |
pagemaker |
Update time: |
2008-10-21 |
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Seminars & Events
From:Scientific Administration Office of IBP
October 21, 2008
IBP Seminar: Multiple functions of the Origin Recognition Complex in Drosophila
| what: |
Multiple functions of the Origin Recognition Complex in Drosophila |
| who: |
Prof. Igor N. Chesnokov
Department of Biochemistry and Molecular Genetics, University of Alabama, School of Medicine, Birmingham, USA |
| when: |
Thursday, October 23, 2008
9?00 a.m. |
| where: |
Lecture Hall in Library, Institute of Biophysics |
| Host: |
Prof. Yingfang Liu |
| More Information: |
The Origin Recognition Complex (ORC), a heteromeric six-subunit protein, is an important component for eukaryotic DNA replication. ORC binds to DNA at replication origin sites in ATP dependent manner and serves as a scaffold for the assembly of other key initiation factors. In addition to its well-documented role in the initiation of DNA replication ORC is also involved in other cell functions. Some of these activities directly link cell cycle progression with DNA replication, while other functions seem distinct from replication. ORC?s function in the establishment of transcriptionally repressed regions is described for many species and may be a conserved feature common for both unicellular eukaryotes and metazoans. ORC subunits are found at the cell membranes and at the cytokinesis furrows of dividing cells as well as at the kinetochore. The exact mechanism of these localizations remains to be determined, however, latest results support the idea that ORC proteins participate in multiple aspects of the chromosome inheritance cycle. These results also suggest that some of the proteins that control initiation of DNA replication are likely to interact with the pathways that connect it with other important cell-cycle events. In this presentation, I will discuss the participation of ORC in various cell functions, in addition to its canonical role in initiating DNA replication.
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