Science, 10 December, 2021, DOI：https://doi.org/10.1126/science.abj6641

Mouse and human share conserved transcriptional programs for interneuron development

Yingchao Shi, Mengdi Wang, Da Mi, Tian Lu, Bosong, Wang, Hao Dong, Suijuan Zhong, Youqiao Chen, Le Sun, Xin Zhou, qiang Ma, Zeyuan Liu, Wei Wang, Junjing Zhang, Qian Wu, Oscar MariN, Xiaoqun Wang

Abstract

The cerebral cortex contains two main classes of neurons that derive from distinct structures in the developing telencephalon. Excitatory neurons originate from progenitor cells in the developing pallium, whereas γ-aminobutyric acid–expressing (GABAergic) interneurons derive from the ganglionic eminences, the transitory structures of the fetal brain that also give rise to the basal ganglia. The general organization and cellular architecture of the telencephalon are conserved among mammals, but its size and complexity vary enormously between rodents and humans. The extent to which differences in early regulatory mechanisms governing the development of the telencephalon shape fundamental differences in this brain structure in rodents and humans remains elusive.

Article link：https://www.science.org/doi/10.1126/science.abj6641