Signal Transduction and Targeted Therapy, 21 March, 2023, DOI：https://doi.org/10.1038/s41392-023-01370-2

TGF-β changes cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy

Na Zhang, Zunling Zhao, Yin Zhao, Lei Yang, Yanhong Xue, Yun Feng, Jianjun Luo, Runsheng Chen, Wei Wei & Yan Qin

Abstract

Pulmonary fibrosis (PF) is characterized by failed alveolar re-epithelialization and fibroblast activation.A continuing struggle in the field has been how to diagnose and treat the disease early and effectively on the basis of shared pathogenetic mechanisms. Transforming growth factor-β (TGF-β) signaling and mitochondria are involved in PF pathogenesis.Mitochondrial respiratory chain complexes (RCCs) I, III, IV, and V comprise both nuclear DNA (nDNA)- and mitochondrial DNA (mtDNA)-encoded subunits, and their biogenesis depends on the cooperation of cytoplasmic (cyto) and mitochondrial (mito) translation.3 To date, a correlation between PF and RCC biogenesis has not been reported.

Article link：https://www.nature.com/articles/s41392-023-01370-2