Science Bulletin, 24 June, 2024, DOI：https://doi.org/10.1016/j.scib.2024.06.028

The romance of replication: Hand in hand, from dawn to dusk

Runze Ma, Zijing Liu, Bing Zhu

Abstract

Faithful DNA duplication is the fundamental event for all life forms. How to replicate the whole genome quickly and efficiently is a challenge that must be faced within every S phase of the cell cycle. Considering the increased size and complexity of mammalian genomes, it is plausible that the regulation of DNA replication is more intricate in mammals. Tens of thousands of replication origins have been identified throughout mammalian genomes. Whether replication forks originated from different origins cooperate during replication is a long-term concern in the field.

Article link：https://www.sciencedirect.com/science/article/pii/S2095927324004535?via%3Dihub