Nucleic Acids Research, 18 October, 2024, DOI：https://doi.org/10.1093/nar/gkae911

MAPbrain: a multi-omics atlas of the primate brain

Liangchen Zhuo, Mengdi Wang, Tingrui Song, Suijuan Zhong, Bo Zeng, Zeyuan Liu, Xin Zhou, Wei Wang, Qian Wu, Shunmin He, Xiaoqun Wang

Abstract

The brain is the central hub of the entire nervous system. Its development is a lifelong process guided by a genetic blueprint. Understanding how genes influence brain development is critical for deciphering the formation of human cognitive functions and the underlying mechanisms of neurological disorders. Recent advances in multi-omics techniques have now made it possible to explore these aspects comprehensively. However, integrating and analyzing extensive multi-omics data presents significant challenges. Here, we introduced MAPbrain (http://bigdata.ibp.ac.cn/mapBRAIN/), a multi-omics atlas of the primate brain. This repository integrates and normalizes both our own lab's published data and publicly available multi-omics data, encompassing 21 million brain cells from 38 key brain regions and 436 sub-regions across embryonic and adult stages, with 164 time points in humans and non-human primates. MAPbrain offers a unique, robust, and interactive platform that includes transcriptomics, epigenomics, and spatial transcriptomics data, facilitating a comprehensive exploration of brain development. The platform enables the exploration of cell type- and time point-specific markers, gene expression comparison between brain regions and species, joint analyses across transcriptome and epigenome, and navigation of cell types across species, brain regions, and development stages. Additionally, MAPbrain provides an online integration module for users to navigate and analyze their own data within the platform.

Article link：https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae911/7825961?login=true