Cell Discovery, 20 March, 2025, DOI：https://doi.org/10.1038/s41421-025-00785-1

Structural characterization reveals substrate recognition by the taurine transporter TauT

Hao Xu, Qinru Bai, Han Wang, Jun Zhao, Aiping Guo, Renjie Li, Qihao Chen, Yiqing Wei, Na Li, Zhuo Huang & Yan Zhao

Abstract

Taurine, an organic acid abundant in animal tissues, is crucial for various physiological processes in humans, particularly in the brain, heart, retina, and skeletal muscles1. Although the body can synthesize taurine, production often falls short, necessitating exogenous supplementation. The taurine transporter (TauT, SLC6A6) plays a vital role in taurine absorption and distribution, facilitating its transport across cell membranes2.

Article link：https://www.nature.com/articles/s41421-025-00785-1