ACS Nano, 24 February, 2026, DOI：https://doi.org/10.1021/acsnano.5c20068

Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects

Zhengguang Wang, Qian Wang, Kaixi Liu, Xing Peng, Jiedong Wang, Shengxin Zeng, Kangchun Wang, Shuai Han, Shilong Su, Jing Ye, Chaoxin Wang, Yuanyu Hu, Zeqi Ren, Caimei Wang, Xiaolin Ma, Jiajia Zheng, Yubao Lu, Peng Wen, Yufeng Zheng, Lizeng Gao*, Yun Tian*, Bingchuan Liu*

Abstract

Infected bone defects pose a major clinical challenge because they typically involve severe infection, poor vascularization, and bone loss. Existing implant materials lack integrated functionality for long-term infection control and tissue regeneration. Here, a multifunctional nanozyme platform consisting of a 3D-printed titanium scaffold functionalized with an iron sulfide multiactivity nanozyme (ISMNzyme)-modified hydrogel is introduced. The platform leverages synergistic peroxidase-like, myeloperoxidase-like, and glutathione peroxidase (GSH-Px)-like activities, alongside the controlled release of Fe²⁺ and polysulfides. This dual mechanism induces ferroptosis-like bacterial death while concurrently promoting angiogenesis and osteogenesis. The platform represents a promising nanozyme-based strategy for the treatment of infected bone defects.

Article link：https://pubs.acs.org/doi/10.1021/acsnano.5c20068