1994 - 1997  BS in Veterinary, Hebei Agriculture University

1997 - 2000  MS in Veterinary Microbiology and Immunology, Nanjing Agricultural University

2000             Ph.D. in Virology, Chinese Academy of Preventive Medicine (CAPM)

2000 - 2002  Assistant Professor, Institute of Virology, Chinese Academy of Preventive Medicine (CAPM)

2002 - 2004  Post Doc associate, School of Medicine, Yale University

2004 - 2008  Post Doc associate, School of Medicine, University of North Carolina

2008 -           Principle investigator, Institute of Biophysics, CAS

2005 - 2006  AmFAR fellowship (The Foundation for AIDS Research)

1. HIV pathogenesis in a Humanized mice model with human immune system.

2. Developing humanized mice model with human immune system and liver for studying HBV and HCV infection and imunopathogenesis.

3. Plasmacytoid dendritic cells and its role in viral infection.

Research papers

1. Cheng L, Ma J, Li J, Li D, Li G, Li F, Zhang Q, Yu H, Yasui F, Ye C, Tsao LC, Hu Z, Su L, Zhang L (2017) Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs. J Clin Invest 127(1):269-279.

2. Zhang X, Yang P, Wang N, Zhang J, Li J, Guo H, Yin X, Rao Z, Wang X, Zhang L (2017) The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein Cell 8(8):590-600.

3. Yin X, Yu H, Jin X, Li J, Guo H, Shi Q, Yin Z, Xu Y, Wang X, Liu R, Wang S, Zhang L (2017) Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions. J Immunol 198(4):1553-1564.

4. Li J1, Du Q, Hu R, Wang Y, Yin X, Yu H, Du P, Plumas J, Chaperot L, Liu YJ, Zhang L (2016) Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production.Protein Cell 7(4):291-4. doi: 10.1007/s13238-015-0239-0.

5. Ma J, Yu H, Yin X, Cheng M, Shi Q, Yin Z, Nie X, Shouli W, Zhang L (2015) E2-2, a novel immunohistochemical marker for both human and monkey plasmacytoid dendritic cells.Biophys Rep 1:139-147. doi: 10.1007/s41048-016-0023-6. Epub 2016 Apr 11

6. Guo H, Zhang J,Zhang X, and Zhang L (2015) SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7. J Immunol 194(10): 4737–4749.

7. Cheng M, Zhang X, Yu H, Du P, Plumas J, Chaperot L, Su L, Zhang L (2015) Characterization of species-specific genes regulated by E2-2 in human plasmacytoid dendritic cells. Sci Rep 17;5:10752. doi: 10.1038/srep10752.

8. Li G, Cheng M, Nunoya J, Cheng L, Guo H, Yu H, Liu YJ, Su L & Zhang L (2014) Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice. PLoS Pathog 10, e1004291.

9. Hu R, Du Q, Yin X, Li J, Wang T & Zhang L (2014) Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment. FEBS Lett 588, 401-407.

10. Yang D, Liu L, Zhu D, Peng H, Su L, Fu YX & Zhang L (2014) A mouse model for HBV immunotolerance and immunotherapy. Cell Mol Immunol 11, 71-78.

11. Li F, Cowley DO, Banner D, Holle E, Zhang L & Su L (2014) Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology. Sci Rep 4, 5290.

12. Dang M, Wang X, Wang Q, Wang Y, Lin J, Sun Y, Li X, Zhang L, Lou Z, Wang J, et al. (2014) Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71. Protein Cell doi: 10.1007/s13238-014-0087-3.

13. Bility MT, Cheng L, Zhang Z, Luan Y, Li F, Chi L, Zhang L, Tu Z, Gao Y, Fu Y, Su L. (2014) Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. PLoS Pathog 10, e1004032.

14. Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, et al. (2012) S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. Acta Crystallogr D Biol Crystallogr 68, 521-530.

15. Ma JP, Xia HJ, Zhang GH, Han JB, Zhang L & Zheng YT (2012) Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques. Cell Mol Immunol 9(5):410-6.

16. Bility MT, Zhang L, Washburn ML, Curtis TA, Kovalev GI & Su L (2012) Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis. Nat Protoc 7, 1608-1617.

17. Du Q, Jiao Y, Hua W, Wang R, Wei F, Ji Y, Du P, Liu YJ, Wu H & Zhang L (2011) Preferential depletion of CD2(low) plasmacytoid dendritic cells in HIV-infected subjects. Cell Mol Immunol 8, 441-444.

18. Zhang L, Jiang Q, Li G, Jeffrey J, Kovalev GI & Su L (2011) Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2(-)/(-)gamma C(-)/(-) mice in vivo. Blood 117, 6184-6192.

19. Washburn ML, Bility MT, Zhang L, Kovalev GI, Buntzman A, Frelinger JA, Barry W, Ploss A, Rice CM & Su L (2011) A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology 140, 1334-1344.

20. Sivaraman V, Zhang L & Su L (2011) Type I interferon contributes to CD4+ T cell depletion induced by infection with HIV-1 in the human thymus. J Virol 85, 9243-9246.

21. Ince WL, Zhang L, Jiang Q, Arrildt K, Su L & Swanstrom R (2010) Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse model. J Virol 84, 2740-2752.

22. Sivaraman V, Zhang L, Meissner EG, Jeffrey JL & Su L (2009) The heptad repeat 2 domain is a major determinant for enhanced human immunodeficiency virus type 1 (HIV-1) fusion and pathogenicity of a highly pathogenic HIV-1 Env. J Virol 83, 11715-11725.

23. Choudhary SK, Rezk NL, Ince WL, Cheema M, Zhang L, Su L, Swanstrom R, Kashuba AD & Margolis DM (2009) Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse. J Virol 83, 8254-8258.

24. Jiang Q, Zhang L, Wang R, Jeffrey J, Washburn ML, Brouwer D, Barbour S, Kovalev GI, Unutmaz D & Su L (2008) FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo. Blood 112, 2858-2868.

25. Holmes D, Jiang Q, Zhang L & Su L (2008) Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis. Immunol Res 41, 248-266.

26. Zhang L, Kovalev GI & Su L (2007) HIV-1 infection and pathogenesis in a novel humanized mouse model. Blood 109, 2978-2981.

27. Meissner EG, Zhang L, Jiang S & Su L (2006) Fusion-induced apoptosis contributes to thymocyte depletion by a pathogenic human immunodeficiency virus type 1 envelope in the human thymus. J Virol 80, 11019-11030.

28. Farr GA, Zhang L & Tattersall P (2005) Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry. Proc Natl Acad Sci U S A 102, 17148-17153.

Invited Reviews

1. Zhang L & Su L (2012) HIV-1 immunopathogenesis in humanized mouse models. Cell Mol Immunol 9, 237-244, doi: 10.1038/cmi.2012.7.

2. Zhang L, Meissner E, Chen J & Su L (2010) Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci 53, 195-203, doi: 10.1007/s11427-010-0059-7 [doi].

(From Liguo Zhang, December 12, 2020)