1989 - 1993  B Sc, Huazhong University of Science and Technology

1993 - 1996  M Sc, Hubei Institute of Chemistry

1996 - 1999  Ph D, Institute of Biophysics, Chinese Academy of Sciences

1999 - 2001  Assistant Professor, Institute of Biophysics, Chinese Academy of Sciences

2001 - 2008  Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

2008 -           Professor, Institute of Biophysics, Chinese Academy of Sciences

1999  President Fellowship of Chinese Academy of Sciences

Mitochondrion is the center for energy metabolism machinery, and the major checkpoint of apoptotic regulation. The homeostasis of mitochondrial network plays essential role in many cellular processes; its dysregulation has been linked to many diseases. We aim to use combined approaches to investigate the mechanism and regulation of the mitochondrial network, and their implication in various human diseases.

Selected Research Articles (*corresponding author)

1. Yanwu Huo*, Lingfei Kong, Ye Zhang, Min Xiao, Sunyuntao Xu, Xiaoxue Yan, Jun Ma*, Taotao Wei*. Structural and biochemical insights into the mechanism of the Gabija bacterial immunity system. Nature Communications, 15(2024), 836.

2. Hong-Yu Li, Min Wang, Xiaoyu Jiang, Yaobin Jing, Zeming Wu, Yifang He, Kaowen Yan, Shuhui Sun, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, Taotao Wei* and Guang-Hui Liu*. CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver. Nucleic Acids Research, (2024), doi.org/10.1093/nar/gkae740.

3. Jialing Zhang, Chaoju Hua, Yu Zhang, Peng Wei*, Yaping Tu*and Taotao Wei*. KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression. Cell Death and Disease 11(2020), 732.

4. Sheng Wang, Yan Xie, Yanwu Huo, Yan Li, Peter W. Abel, Haihong Jiang, Xiaohan Zou, Haizhan Jiao, Xiaolin Kuang, Dennis W. Wolff, Youguo Huang, Thomas B. Casale, Reynold A. Panettieri Jr., Taotao Wei*, Zhengyu Cao* and Yaping Tu*. Airway relaxation mechanisms and structural basis of osthole to improve lung function in asthma. Science Signaling, 13(2020), eaax0273.（封面论文）

5. Li Ma, Shuxin Hu, Xiaolong He, Na Yang, Licui Chen, Chenguang Yang, Fangfu Ye, Taotao Wei* and Ming Li*. Detection of tBid oligomerization and membrane permeabilization by graphene-based single-molecule surface-induced fluorescence attenuation. Nano Letters 19(2019), 6937-6944.

6. Peng Wei, Yan Xie, Peter W. Abel, Yapei Huang, Qin Ma, Linghai Li, Junfeng Hao, Dennis W. Wolff, Taotao Wei* and Yaping Tu*. Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis. Cell Death and Disease 10(2019), 670.

7. Yang Xu, Jinqi Ren, Xiaolong He, Han Chen, Taotao Wei* and Wei Feng*. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy 15(2019), 1017-1030.

8. Yipeng Du, Hao Hu, Xiaoxia Pei, Kang Du and Taotao Wei*. Genetically encoded FapR-NLuc as a biosensor to determine Malonyl-CoA in situ at subcellular scales. Bioconjugate Chemistry 30(2019), 826-832.

9. Yipeng Du*, Hao Hu, Saisi Qu, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, Junfeng Hao, Pingsheng Liu, Fuquan Yang, Tingting Li* and Taotao Wei*. SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice. EBioMedicine 36(2018), 347-357.

10. Ping Zhu, Yongzhang Liu, Fenglin Zhang, Xiufeng Bai, Zilei Chen, Fugen Shangguan, Bo Zhang, Lingyun Zhang, Qianqian Chen, Deyao Xie, Linhua Lan, Xiangdong Xue, Xingjie Liang, Bin Lv*, Taotao Wei* and Yan Qin*. Human Elongation Factor 4 regulates cancer bioenergetics by acting as a mitochondrial translation switch. Cancer Research 78(2018), 2813-2824.

Reviews (*corresponding author)

1. Hejiang Zhou*, Yanwu Huo, Na Yang, Taotao Wei*. Phosphatidic acid: from biophysical properties to diverse functions. The FEBS Journal, 291(2024), 1870-1885.

2. 卫涛涛*，陈佺*，徐涛*，陈晔光*. 中国细胞器互作研究的进展和趋势. 中国科学：生命科学, 52(2022), 1-4.

3. Bo Zhang, PengWei, Zhixiang Zhou and Taotao Wei*. Interactions of graphene with mammalian cells: Molecular mechanisms and biomedical insights. Advanced Drug Delivery Reviews 105 (2016) 145-162.

4. Yipeng Du and Taotao Wei*. Inputs and outputs of insulin receptor. Protein & Cell 5(2014), 203-213.

(From Taotao Wei, September 12, 2024)