1986 - 1990  B.S., Nankai University, Tianjin, China

1990 - 1993  M.S., Beijing Normal University, Beijing, China

1993 - 1996  Ph.D., Peking University, Beijing, China

1996 - 1998  Assistant Professor, Institute of Biophysics, CAS

1998 - 2000  Associate Professor, Institute of Biophysics, CAS Visiting Scientist in the Institute of Food Research, Norwich, UK (The Royal Society K.C. Wong Research Fellowship)

2000 -           Principle Investigator (PI ) (2004, full professor. Institute of Biophysics, CAS.)

2004 - 2005  Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK

2015 -           Distinguished Professor, University of Chinese Academy of Sciences

2015 -           Member, CAS Centre for Excellence in Biomacromolecules

2018             Visiting Scientist, National Institute of Neurological Disorders and Stroke (NINDS), NIH.

2012 - 2023  Vice Director of National Laboratory of Biomacromolecules

2015  Special Government Allowances of the State Council

2014  Outstanding Contribution, CAS-Beijing

2012  National Outstanding Young Scientist

2006  Young Scientist Award Society for Free Radical Research (SFRR)-Asia

Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency results in impaired homeostasis and is associated with pathology, such as aging, cancer, atherosclerosis, neurodegenerative diseases, obesity, and diabetes. Our research has been focused on the crosstalk between these small molecules and biomacromolecules, trying to explore the relationship between protein function and cellular redox status. Based on it, try to find out effective approach to maintain cellular redox homeostasis and apply for good health and anti-aging. We are also interested in the scientific mechanism of traditional Chinese medicine (TCM) and its application.

1. To explore Redox network - Redox map - Redox signaling: Through whole genome screening, we aim to identify new redox regulatory genes to elucidate the composition of redox family and the crosstalk between redox active small molecules and biomacromolecules. With the help of redox-specific probes, we are trying to draw high-resolution redox maps of cells to obtain a basic understanding of precise cellular redox states under various physiological, pathological and stress conditions. Furthermore, we continue illustrating the mechanism of redox signaling, particularly nitric oxide and S-nitros(yl)ation and other thiol modification in cellular quality control, aging and age-related diseases.

2. To explore Redox stress and Aging: Why anti-aging by antioxidant intervention does not work as expected according to the Free radical theory of aging? Our hypothesis is that the physiological function of redox stress in anti-aging process was neglected and the antioxidant intervention is not based on the precision cellular redox nature. We then proposed the concept of Precision Redox and the "5R" principles as the key for antioxidant pharmacology, i.e., Right species, Right place, Right time, Right level and Right target as guidelines for redox medicine development. Furthermore, we have found that the Redox-stress Response Capacity (RRC) decay is a substantive characteristic of aging and have discovered an insulin-resistance-like phenomenon in senescent cells, termed Redox-stress Response Resistance (RRR). We further identified the point of transition between eustress and distress, and named it as Redox-stress Signalling Threshold (RST), which is not fixed but modifiable. Based on these RRC-RRR-RST novel concepts of redox response in aging, we advocates a proactive health strategy: elevation of RST through early stage stimulation to potentiate RRC while diminishing RRR, thereby delaying the aging process. We proposed that anti-aging should better start from the early stage of life.

3. The scientific connotation of traditional Chinese medicine (TCM) and its application. We have demonstrated the mechanisms of the effect of L. barbarum on "muscle and bone strengthening and anti-aging" as recorded in "Ben Cao Gang Mu". Our study revealed the molecular mechanism of the effects of L. barbarum extract on preventing age-related osteoporosis, enhancing skeletal muscle endurance, preventing age-related muscle stem cell loss and promoting whitening. The research results will provide scientific basis for the development of effective ingredients of L. barbarum into clinical drugs, and may further provide a research model for the development of other traditional Chinese medicine.

4. Function, mechanism and the translational research of S-nitrosoglutathione reductase (GSNOR) and phosphatidylinositol 4-kinase type IIα (PI4KIIα). Our results demonstrate that GSNOR might be a new potential target for the treatment of age-related cognitive impairment (J Neurosci. 2017), cardiovascular diseases (J Mol Cell Cardiol. 2017; Redox Biol. 2018; Redox Biol. 2019) and antiviral innate immunity by restricting TANK-binding kinase 1 (TBK1) cysteine S-nitrosation (Redox Biol. 2021) and specific GSNOR activator and inhibitor are under development. About the study of PI4K, based on our previous work about the structure and function of PI4KIIα (Oncogene, 2010; Protein Cell, 2014; Nature Communications, 2014), PI-273, a substrate-competitive, specific small-molecule inhibitor of PI4KIIα was identified (Cancer Res. 2017) and the translational research is undergoing.

1. Sun C, Su J, Wang J, Ding K*, Chen C*. Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures. The FASEB Journal. 2024;38:e70010.

2. Su LY^#, Jiao L^#, Liu Q^#, Qiao X^#, Xie T, Ma Z, Xu M, Ye MS, Yang LX, Chen C*, Yao YG*. S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation. Redox Biol. 2024 Jun 14;75:103239.

3. Ou Q^#, Qiao X^#, Li Z^#, Niu L, Lei F, Cheng R, Xie T, Yang N, Liu Y, Fu L, Yang J, Mao X, Kou X, Chen C* Shi S*. Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation. Cell Metab. 2024 Jan 2; 36(1):78-89.e5.

4. Yang Q^#, Yan R^#, Zhang J^#, Zhang T, Kong Q, Zhang X, Xia H, Ye A, Qiao X, Kato K, Chen C*, An Y*. Reductive stress induced by NRF2/G6PD through glucose metabolic reprogramming promotes malignant transformation in Arsenite-exposed human keratinocytes. Sci Total Environ. 2023 Oct 20;896:165207.

5. Lv Z^#, Meng J^#, Yao S^#, Xiao F^#, Li S, Shi H, Cui C, Chen K, Luo X*, Ye Y*, Chen C*. Naringenin improves muscle endurance via activation of the Sp1-ERRγ transcriptional axis. Cell Reports. 2023 Oct 23;42(11):113288.

6. Hossain MS^#, Yao A^#, Qiao X^#, Shi W, Xie T, Chen C*, Zhang YQ*. Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth. J Cell Biol. 2023 Sep 4;222(9):e202202068.

7. Guo M^#, Qiao X^#, Wang Y^#, Li Z^#, Shi C, Chen Y, Kang L, Chen C*, Zhou X*. Mitochondrial translational defect extends lifespan in C. elegans by activating UPR^mt. Redox Biol. 2023 July;63:102722.

8. Meng J, Wang Y, Lv Z, Qiao X, Ye A, Zhu Q, Chen C*. Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells. Sci China Life Sci. 2023 May 6.

9. Aging Biomarker Consortium; Bao H^#, et al., Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JJ*, Huang K*, Ju Z*, Kong QP*, Li J*, Li J*, Li X*, Liu B*, Liu F*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Songyang Z*, Sun YE*, Sun Y*, Tian M*, Wang S*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong CCL*, Xiang AP*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C*, Zhang H*, Zhang L*, Zhang W*, Zhang Y*, Zhang YW*, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Sci China Life Sci. 2023 May;66(5):893-1066.

10. Meng J^#, Lv Z^#, Chen X^#, Sun C, Jin C, Ding K*, Chen C*. LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1. iScience. 2023 Apr 6;26(5):106573.

11. Zhang H^#, Yu F^#, Xie P^#, Sun S^#, Qiao X^#, Tang S, Chen C, Yang S, Mei C, Yang D, Wu Y, Xia R, Li X, Lu J, Liu Y, Xie X, Ma D, Xu X, Liang Z, Feng Z, Huang X, Yu H, Liu G, Wang Y, Li J, Zhang Q, Chen C, Ouyang Y*, Xie Q*. A Gγ protein regulates alkaline sensitivity in crops. Science. 2023 Mar 24;379(6638):eade8416.

12. Sun C^#, Chen X^#, Yang S, Jin C, Ding K*, Chen C*. LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRA/BMPRII/Noggin. Carbohyd Polym. 2023, 310: 120725.

13. Zhang Y^#, Qiao X^#,*, Liu L^#, Han W, Liu Q, Wang Y, Xie T, Tang Y, Wang T, Meng J, Ye A, He S, Chen R*, Chen C*. Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8. Redox Biol. 2022, Aug; 54:102383.

14. Qiao X, Zhang Y, Ye A, Zhang Y, Xie T, Lv Z, Shi C, Wu D, Chu B, Wu X, Zhang W, Wang P, Liu GH, Wang CC, Wang L*, Chen C*. ER reductive stress caused by Ero1α S-nitrosation accelerates senescence. Free Radic Biol Med. 2022 Feb 20;180:165-178.

15. Meng J, Lv Z, Wang Y, Chen C*. Identification of the redox-stress signaling threshold (RST): Increased RST helps to delay aging in C. elegans. Free Radic Biol Med. 2021 Nov 27;178:54-58.

16. Liu Q^#, Gu T^#, Su LY^#, Jiao L, Qiao X, Xu M, Xie T, Yang LX, Yu D, Xu L, Chen C*, Yao YG*. GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation. Redox Biol. 2021 Nov;47:102172.

17. Deng H^#, Qiao X^#, Xie T, Fu W, Li H, Zhao Y, Guo M, Feng Y, Chen L, Zhao Y, Miao L, Chen C*, Shen K*, Wang X*. SLC-30A9 is required for Zn²⁺ homeostasis, Zn²⁺ mobilization, and mitochondrial health. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2023909118.

18. Cai WB, Zhao YJ, Liu L, Cheng Q, Wang J, Shi XL, Yao L, Qiao XH, Zhu Y, Chen C*, Zhang X*. Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury. Free Radic Biol Med. 2021 Jul 9;173:7-18.

19. Yi W^#, Zhang Y^#, Liu B^#,*, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z*, Chen C*, Ju Z*. Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration. Cell Rep. 2021 Mar 30;34(13):108922.

20. Meng J, Lv Z, Zhang Y, Wang Y, Qiao X, Sun C, Chen Y, Guo M, Han W, Ye A, Xie T, Chu B, Shi C, Yang S, Chen C*. Precision Redox: The Key for Antioxidant Pharmacology. Antioxid Redox Signal. 2021 May 10;34(14):1069-1082.

21. Meng J^#, Lv Z^#, Sun C, Qiao X, Chen C*. An extract of Lycium barbarum mimics exercise to improve muscle endurance through increasing type IIa oxidative muscle fibers by activating ERRγ. FASEB J. 2020 Sep;34(9):11460-11473.

22. Zheng WQ^#, Zhang Y^#, Yao Q^#, Chen Y^#, Qiao X, Wang ED*, Chen C*, Zhou XL*. Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation. Nucleic Acids Res. 2020 Jul 9;48(12):6799-6810.

23. Ban Y^#, Liu Y^#, Li Y, Zhang Y, Xiao L, Gu Y, Chen S, Zhao B, Chen C*, Wang N*. S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension. Redox Biol. 2019 Feb;21:101099.

24. Li J, Zhang Y, Zhang Y, Lü S, Miao Y, Yang J, Huang S, Ma X, Han L, Deng J, Fan F, Liu B, Huo Y, Xu Q, Chen C*, Wang X*, Feng J*. GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation. Redox Biol. 2018 Jul;17:386-399.

25. Li J, Gao Z, Zhao D, Zhang L, Qiao X, Zhao Y, Ding H, Zhang P, Lu J, Liu J, Jiang H, Luo C*, Chen C*. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6253-6266.

26. Zhang Y, Wu K, Su W, Zhang DF, Wang P, Qiao X, Yao Q, Yuan Z, Yao YG, Liu G, Zhang C, Liu L, Chen C*. Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKIIα. J Neurosci. 2017 Oct 4;37(40):9741-9758.

27. Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, Qiao X, Zhang X, Xu T, Liu G, Li P, Chen C*. Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Autophagy. 2017 Jul 3;13(7):1145-1160.

28. Meng J, Lv Z, Qiao X, Li X, Li Y, Zhang Y, Chen C*. The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging. Redox Biol. 2017 Apr;11:365-374.

29. Yin R, Fang L, Li Y, Xue P, Li Y, Guan Y, Chang Y, Chen C*, Wang N*. Pro-inflammatory Macrophages suppress PPARγ activity in Adipocytes via S-nitrosylation. Free Radic Biol Med. 2015 Dec;89:895-905.

30. Zhou Q^#, Li J^#, Yu H, Zhai Y, Gao Z, Liu Y, Pang X, Zhang L, Schulten K*, Sun F*, Chen C*. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nat Commun. 2014 Mar 28;5:3552.

31. Wu K^#, Ren R^#, Su W^#, Wen B, Zhang Y, Yi F, Qiao X, Yuan T, Wang J, Liu L, Izpisua Belmonte JC*, Liu GH*, Chen C*. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J Biol Chem. 2014 Jul 18;289(29):20193-9.

32. Mao K^#, Chen S^#, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W, Chen C*, Meng G*, Sun B*. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res. 2013 Feb; 23(2):201-12.

33. Huang B, Chen C*. Detection of protein S-nitrosation using irreversible biotinylation procedures (IBP). Free Radic Biol Med. 2010 Aug 1;49(3):447-56.

34. Li J, Lu Y, Zhang J, Kang H, Qin Z*, Chen C*. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. Oncogene. 2010 Apr 29;29(17):2550-9.

35. Qu J^#, Liu GH^#, Wu K, Han P, Wang P, Li J, Zhang X, Chen C*. Nitric oxide destabilizes Pias3 and regulates sumoylation. PLoS One. 2007 Oct 31;2(10):e1085.

36. Qu J, Liu GH, Huang B, Chen C*. Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310. Nucleic Acids Res. 2007;35(8):2522-32.

37. He J^#, Wang T^#, Wang P, Han P, Yin Q, Chen C*. A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: the occurrence and regulation of protein S-nitrosylation is the checkpoint. J Neurochem. 2007 Sep;102(6):1863-1874.

38. Huang B, Chen C*. An ascorbate-dependent artifact that interferes with the interpretation of the biotin switch assay. Free Radic Biol Med. 2006 Aug 15;41(4):562-7.

39. Huang B^#, Zhang J^#, Hou J, Chen C*. Free radical scavenging efficiency of Nano-Se in vitro. Free Radic Biol Med. 2003 Oct 1; 35(7):805-13.

40. Chen C, Wei T, Gao Z, Zhao B, Hou J, Xu H, Xin W*, Packer L. Different effects of the constituents of EGb761 on apoptosis in rat cerebellar granule cells induced by hydroxyl radicals. Biochem Mol Biol Int. 1999 Mar;47(3):397-405.

Patents

1. Chang Chen, Kan Ding, Xingke Yang, Chuanxin Sun, Xia Chen, Can Jin. COMPOSITION COMPRISING HOMOGENEOUS POLYSACCHARIDE OR DERIVATIVE THEREOF AND METHOD OF USING THE SAME TO PREVENT AND/OR TREAT BONE LOSS. Patent Application No. PCT/IB2023/000414. Public No. WO 2024/013562 A1.

2. Chang Chen, Kan Ding, Xingke Yang, Jiao Meng, Can Jin, Zhenyu Lv, Chuanxin Sun, Xia Chen. COMPOSITION COMPRISING HOMOGENEOUS POLYSACCHARIDE AND METHOD OF USING THE SAME TO IMPROVE MUSCLE SATELLITE CELLS. Patent Application No.PCT/IB2023/000278. Public No.WO2023223098A1.

3. Chang Chen, Yang Ye, Xingke Yang, Kaixian Chen, Xiaomin Luo, Jiao Meng, Sheng Yao, Zhenyu Lv. COMPOSITION COMPRISING NARINGENIN OR DERIVATIVE THEREOF, METHOD OF MAKING AND METHOD OF USING THE SAME. Patent Application No.PCT/IB2023/000179. Public No. WO2023180813A1.

4. Chang Chen, Jiao Meng, Zhenyu Lv, Chuanxin Sun, Xinhua Qiao, LYCIUM BARBARUM EXTRACTS, RESULTING COMPOSITIONS, METHODS OF MAKING AND METHODS OF USING THE SAME. Patent Application No. 42021042963.5. Patent No.HK40052396. Date of Patent: Sep. 2, 2022. (Hong Kong)

5. Chang Chen, Jiao Meng, Zhenyu Lv, Chuanxin Sun, Xinhua Qiao, LYCIUM BARBARUM EXTRACTS, RESULTING COMPOSITIONS, METHODS OF MAKING AND METHODS OF USING THE SAME. Patent No. US11, 135, 260 B2, Date of Patent: Oct. 5, 2021.

6. Chang Chen, Jiao Meng, Zhenyu Lv, Chuanxin Sun, Xinhua Qiao, LYCIUM BARBARUM EXTRACTS, RESULTING COMPOSITIONS, METHODS OF MAKING AND METHODS OF USING THE SAME. Patent No. ZL202110023756.8, Date of Patent: Jan. 8, 2022.

7. Xiaolin Tong, Chang Chen, The invention relates to an antidepressant drug composition and a preparation method and application. Patent No: ZL201811628807.4, Date of Patent: Dec. 17, 2021.

8. Xiaolin Tong, Chang Chen, The invention relates to a drug composition for treating diabetes and a preparation method and application. Patent No: ZL 201811626580.X, Date of Patent: Oct. 22, 2021.

9. Chang Chen，Cheng Luo，Hualiang Jiang , Jiangmei Li, Zhen Gao, Dan Zhao, Lunfeng Zhang, Xinhua Qiao, The application of PI-273, the specific inhibitor of PI4KIIα. Patent No: ZL 201510831539.6, Date of Patent: Jan. 29, 2021.

10. Yi Wan，Chang Chen，Lei Gao, Yuying Zhang, Xinhua Qiao, Yan Wang, Method, target and application for NO accumulation to decrease Pseudomonas aeruginosa invasiveness. Patent No: US 10537593B2, United States, Date of Patent: Jan. 21, 2020.

11. Yi Wan，Chang Chen，Lei Gao, Yuying Zhang, Xinhua Qiao, Yan Wang, Method, target and application for NO accumulation to decrease Pseudomonas aeruginosa invasiveness, Patent No: ZL 201510697439.9, Date of Patent: May 17, 2019

12. Chang Chen, Bo Huang, A specific method for detection of thiol modification and its application. Patent No: ZL200910084155.7, Date of Patent: Aug. 28, 2013.

13. Chang Chen, Jiangmei Li "The application of Phosphatidylinositol 4-Kinase Type IIα (PI4KIIα) as a potential target for drug discovery". Patent No: ZL200810104272.0, Date of Patent: May 8, 2013.

Book Chapters

1. Chang Chen, Free Radical Biology. Encyclopedia of China, 2017.

2. Chang Chen, H. R. Tang, and P. Belton. Natural antioxidants - an ESR perspective, in "Magnetic Resonance in Food Science", pp117-128, edited by G.A. Webb, published by the Royal Society of Chemistry, UK. 2000.

3. Chang Chen. Functions and the mechanism of nitric oxide. Invited chapter in: Free Radical Biology and Medicine, edited by R. L Zheng, Yixuan Publishers, Taiwan, 2013. ISBN 978-957-616-983-0.

Graduate Student Training (as Mentor)

● Currently running a research group of 20 people (2 associate professors, 3 research assistants, 13 PhD students, and 1 technician).

● Two PhD have completed postdoctoral studies; 24 students have already completed their PhD; 10 students have completed a Master's.

● 2 have become PIs at other CAS institutes:

Jie He, Professor, Center for Excellence in Brain Science and Intellligence Technology, Chinese Academy of Sciences;

Jing Qu, Professor, Institute of Zoology，Chinese Academy of Sciences. 

Selected Invited Professional Presentations

2024 Analysis of scientific connotation of anti-aging effect of Lycium barbarum, 2024 China Aging Science Conference (CASC), 2024.4.26-28, Wenzhou, China. (Invited speaker)

2023 Say NO to aging, Society of Free Radical Research Korea Symposium，2023.11.24-26, Korea. (Invited speaker)

2023 The main problems and challenges of redox biology and medical research, 2023 Chinese Congress of Redox Biology and Medicine, 2023.8.10-13, Xiamen, China. (Chair and Plenary Speaker)

2023 Precision redox: The key for antioxidant pharmacology, 25^th International Conference on Redox Medicine, 2023.6.21-23, Paris, France. (Invited speaker)

2022 Improving RST-RRC as active health strategy and precision redox regulation in anti-aging, the 10^th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia 2022), Nov. 4-6, 2022, on line. (Invited Speaker)

2021 Cellular Precision Redox Regulation, Chinese Society of Metabolic Biology, Metabolic H-Talk No.98, Oct.9, 2021, on-line. (Invited Speaker)

2021 Redox-stress response capacity decline and ER reductive stress in aging, 20^th Biennial Meeting of SFRR International Online Congress, Mar. 15-18, 2021, on line. (Invited Speaker and Session Chair)

2019 Redox modification of protein sulfhydryl and aging, 2019 National Academic Conference of Chinese society of Biochemistry and molecular biology, Oct. 24-27, 2019, Taiyuan, China. (Invited Speaker)

2019 Redox response resistance and aging, 17^th Chinese Biophysics Congress, Aug.2-4, 2019, Tianjin, China. (Invited Speaker)

2019 The effect and mechanism of Endoplasmic Reticulum reductive stress on aging, International Conference on Aging Biology 2019, Apr. 18-21, 2019, Beijing, China. (Invited Speaker)

2019 Increased GSNOR causes age-related cognitive impairment via denitrosation of CaMKIIα, The 9^th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), Apr. 4-7, 2019, Kyoto, Japan. (Invited Speaker)

2018 Redox-stress Response Capacity and Aging, Cold Spring Harbor Asia Conference on Iron, Reactive Oxygen Species, and Ferroptosis in Life, Death & Disease, Nov 26-30, 2018, Suzhou, China. (Invited Speaker)

2018 Increased GSNOR causes age-related cognitive impairment via denitrosylation of CaMKIIα, International Conference on Ageing Biology and Chinese Society of Aging Biology Annual Meeting, Oct 19-21, 2018, Changsha, China. (Invited Speaker)

2017 Say NO to aging related cognitive impairment and metabolic disorder, 15^th Chinese Biophysics Congress, Nov 3-6, Shanghai, China. (Invited Speaker)

2017 The decay of Redox-stress Response Capacity (RRC) is a substantive characteristic of aging: revising the redox theory of aging. The 8^th Biennial Meeting of SFRR Asia and the 14^th Conference of the Asian Society of Mitochondrial Research and Medicine. Sep 8-11, Xi'an, China. (Invited Speaker)

2017 The decay of Redox-stress Adaptive Capacity is a substantive characteristic of aging: revising the redox theory of aging. EMBO Conference on Redox Biology. Jul 15-23, Moscow-St Petersburg, Russia. (Invited Speaker)

2016 Reductive stress of ER and its function in aging, The 23^rd Annual Meeting of the Society for Redox Biology and Medicine, Nov 16-19, 2016, San Francisco, America. (Plenary speaker and Session Chair)

2015 The homeostasis of nitric oxide and S-nitrosothiols in nervous system, The 7^th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), Nov 29-Dec. 2, 2015, Chiang Mai, Thailand. (Invited Speaker)

2014 A novel suppressive effect of S-nitroglutathione reductase in neurogenesis, at the 17^th Biennial Meeting of Society for Free Radical Research International (SFRRI 2014) , March 23 -26, 2014, Kyoto, Japan. (Invited Speaker and Session Chair)

2013 Function and structure study of phosphatidylinositol 4-kinase II alpha. The 6^th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), Oct. 16-20, 2013, Chang Gung University, Taiwan. (Invited Speaker)

2012 S-nitrosation and NO metabolism. The 1^st International Chinese Symposium on Free Radical Research, August 7-9, 2012, Lanzhou, China. (Invited Speaker)

2012 Say "NO" to SUMOylation: Crosstalk between S-nitrosation, ubiquitination and sumoylation. Gordon Research Conference (GRC) on Oxygen Radicals, Feb.5-10, 2012, Ventura, California, USA. (Invited Speaker)

2011 Functional study and method developing of S-nitrosation. The 5^th Biennial Meeting of SFRR-Asia. Aug.31 - Sep 4, 2011, Kagoshima, Japan. (Invited Speaker and Session Chair)

2010 Specific Detection of Protein S-Nitrosation Using Irreversible Biotinylation Procedures (IBP). GRC on Oxygen Radicals, Feb. 7-12, 2010, Ventura, California. (Invited Speaker)

2009 Repression of classical nuclear export by S-nitrosylation of CRM1. The 4^th International Meeting of SFRR-Asia, July 8-12, 2009, Malaysia. (Invited Speaker)

2008 The redox-based post-translational modification of proteins: S-nitros(yl)ation as an example. The Annual Meeting of the Beijing Society of Biochemistry and Molecular Biology, Dec. 6, 2008, Beijing, China. (Plenary Speaker)

2008 A novel crosstalk between S-nitrosation, ubiquitination, and sumoylation: NO regulates sumoylation through S-nitrosation-dependent degradation of Pias3. The 14^th Biennial Meeting of the Society for Free Radical Research International (14^th SFRRI). Oct. 18-22, 2008, Beijing, China. (Invited speaker and session chair)

2008 Cellular redox regulation and health, Beijing International Forum on Health, Dec. 26-28, 2008, Beijing, China. (Plenary Speaker)

2007 "S-nitrosylation as a switch of the translocation of APE1/REF1". The 3^rd international meeting of the society for free radical research (SFRR)-Asia，Jan. 8-11, 2007, India. (Invited speaker)

2006 "Proteomic analysis of S-nitrosation in spinach chloroplasts：much more beyond S-nitrosated target screening", The 13^th International Congress of the Society for Free Radicals International （13^th SFRR）, Aug.15-19, 2006 in Davos, Switzerland. SFRR- Asia Award for 2006.

2005 A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: the occurrence and regulation of S-nitrosylation of proteins is the checkpoint. The 2^nd international meeting of the society for free radical research (SFRR)-Asia and The 3rd international symposium on natural antioxidants-molecular mechanisms and health effects (ISNA)，Jun. 24-29, 2005, Shanghai, China. (Invited speaker and session chairperson)

2003 The endoplasmic reticulum stress is a mechanism of S-nitrosoglutathione-induced neurotoxicity in cerebella granule cells. The 1^st International Meeting of the Society for Free Radical Research (SFRR)-Asia, Nov. 6-8, 2003, Seoul, Korea. (Invited speaker)

2000 Natural antioxidants and free radicals - an ESR perspective. The 2^nd International Conference on Applications of Magnetic Resonance in Food Science, Sep. 18-20, 2000, Aveiro, Portugal. (Plenary Speaker) 

Conference organisation

1. 2023 Chinese Congress of Redox Biology and Medicine, 2023.08.10-12, Xiamen China. (Organizer and Chair)

2. "Women and Biophysical Beauty" Forum, Women in Science Forum of 16th Chinese Biophysics Congress, 2018, Chengdu, China. (Organizer and Co-Chair)

3. The 4^th Sino-German Symposium on Protein Folding, Redox Regulation and Quality Control, Oct 17-19, 2017, Beijing, China. (Organizer and Co-Chair).

4. The Annual Meeting of the Beijing Society of Biochemistry and Molecular Biology, Dec. 3, 2016, Beijing, China (Organizer and Chair).

5. The 14^th Chinese Biophysics Congress, 16-20 Nov. 2015, Kunming, China. (Organizer and Chair for Women Scientist Forum; Co-Chair for Parallel Session: Free radical biology and medicine).

6. The 2^nd International Chinese Symposium on Free Radical Research, Nov.14-16, 2014, Hong Kong, China. (Organizer and Co-Chair).

7. The 1^st International Chinese Symposium on Free Radical Research, August 7-9, 2012, Lanzhou, China. (Organizer and Co-Chair).

8. The 17^th International Biophysics Congress (IUPAB), Oct. 30th to Nov. 3rd, 2011, (Local Organizing Committee Member and Co-Chair for Parallel Session: Free radical biology and medicine, Organizer and Chair for Women Scientist Forum)

9. The 11^th national conference of biophysics, July 12-16, 2009, Guilin, China. (Co-Chair for satellite meeting Free radical biology and medicine)

10. The 14^th Biennial Meeting of the Society for Free Radical Research International (14^th SFRRI). October 18-22, 2008, Beijing, China. (Co-Chair of scientific program)

(From Chang Chen, September 12, 2024)