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Zhixin Wang, Ph.D, Prof., CASM

Principal Investigator
National Laboratory of Biomacromolecules, IBP


Research Interests: Biochemistry and structural biology


Email: zxwang@ibp.ac.cn/zhixinwang@mail.tsinghua.edu.cn


Tel: 010-64889890


Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China


Chinese personal homepage


 

Biography

1988             Ph.D. Institute of Biophysics, Academia Sinica

1989 - 1993  Postdoctoral associate, Cornell University and North Dakota State University, USA

1993 -           Professor, Institute of Biophysics, Academia Sinica

I have published more than 70 papers in biochemistry and structural biology, and my present research interests center on the physical chemistry of protein, kinetics of enzyme catalysis and regulation, protein-ligand interaction and prediction of protein three-dimensional structure.

Awards
 
Membership in Academies & Societies
 
Research Interests
 
Grants
 
Selected Publications

1. Li-Sha Zheng, Yuan-Yuan Zhang, Jia-Wei Wu, Zhenguo Wu, Zhong-Yin Zhang, Zhi-Xin Wang, A continuous spectrophotometric assay for mitogen-activated protein kinase kinases, Anal. Biochem. 2012 421 191-197

2. Hongwei Yao, Yingang Feng, Tao Zhou, Jinfeng Wang, Zhi-Xin Wang, NMR Studies of the Interaction between Human Programmed Cell Death 5 and Human p53, Biochemistry 2012 51 2684-2693

3. Tian Xie, Ruobing Ren, Yuan-yuan Zhang, Yuxuan Pang, Chuangye Yan, Xinqi Gong, Yuan He, Wenqi Li, Di Miao, Qi Hao, Haiteng Deng, Zhixin Wang, Jia-Wei Wu, Nieng Yan, Molecular Mechanism for Inhibition of a Critical Component in the Arabidopsis thaliana Abscisic Acid Signal Transduction Pathways, SnRK2.6, by Protein Phosphatase ABI1, J. Biol. Chem. 2012 287 794-802

4. Yuan-Yuan Zhang, Jia-Wei Wu, Zhi-Xin Wang, Mitogen-activated Protein Kinase (MAPK) Phosphatase 3-mediated Cross-talk between MAPKs ERK2 and p38, J. Biol. Chem. 2011 286

5. Jue Wang, Jia-Wei Wu, Zhi-Xin Wang, Mechanistic Studies of the Autoactivation of PAK2, A TWO-STEP MODEL OF CIS INITIATION FOLLOWED BY TRANS AMPLIFICATION, J. Biol. Chem. 2011 286 2689-2695

6. Yi-Tong Liu, Qiong-Jie Dan, Jiawei Wang, Yingang Feng, Lei Chen, Juan Liang, Qinxi Li, Sheng-Cai Lin, Zhi-Xin Wang, Jia-Wei Wu, Molecular Basis of Wnt Activation via the DIX Domain Protein Ccd1, J. Biol. Chem. 2011 286 8597-8608

7. Yuan-Yuan Zhang, Jia-Wei Wu, Zhi-Xin Wang, A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38a with the MAPK Binding Domain of the Phosphatase MKP5, Sci. Signal. 2011 4

8. Jue Wang, Jia-Wei Wu, Zhi-Xin Wang, Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase , Structure 2011 19 1752-1761

9. Lei Chen, Zhi-Hao Jiao, Li-Sha Zheng, Yuan-Yuan Zhang, Shu-Tao Xie, Zhi-Xin Wang, Jia-Wei Wu1, Structural insight into the autoinhibition mechanism of AMP-activated protein kinase, Nature 2009 459 1146-U139

10. Rui Hao,a Lei Chen,b Jia-Wei Wub,Zhi-Xin Wang, Structure of Drosophila Mad MH2 domain, Acta Crystallogr. F- 2008 64 986-990

 

(From Zhixin Wang, January 13, 2014)

 

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Address: No 15 Datun Road, Chaoyang District, Beijing

Postcode: 100101