Shan Shan, Ph.D, Associate Professor
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Member of the Youth Innovation Promotion Association of CAS
National Laboratory of Biomacromolecules , IBP
Research Interests: Molecular mechanisms of the remodelling complex
Email: shanshan@ibp.ac.cn
Tel: 010-64889948
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
2007 - 2012 Ph.D., School of Medicine, Tsinghua University,Beijing
2012 - 2016 Assitant Professor, Institute of Biophysics, CAS,Beijing
2017 - Associate Professor, Institute of Biophysics, CAS,Beijing
- Awards
- Membership in Academies & Societies
- Research Interests
Dr. Shan is working on the understanding of molecular mechanisms of the remodelling complex (such as SWR1,INO80,SRCAP) catalyzed chromatin histone exchange and their potential application in therapeutics and diagnostics against human dieases. AND also the molecular mechanisms of epgenetic regulations during viruses infection which can help us to understand host-virus interaction, virus evolutional strategy and taxonomy of viruses.
- Grants
- Selected Publications
1. Dai Y*, Zhang A*, Shan S*, Gong Z#, Zhou Z#. Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR. Nature communications ,2018, 9(1): 2123.
2. Liang X*, Shan S*, Pan L*, Zhao J*, Ranjan A, Wang F, Zhang Z, Huang Y, Feng H, Wei D, Huang L, Liu X, Zhong Q, Lou J, Li G, Wu C#, Zhou Z#. Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. Nature structural & molecular biology, 2016, 23(4): 317-323.
3. Shan S*#, Min H*, Liu T, Jiang D, Rao Z. Structural insight into dephosphorylation by trehalose 6-phosphate phosphatase (OtsB2) from Mycobacterium tuberculosis. FASEB journal ,2016, 30(12): 3989-3996.
4. Shan S*, Chen X*, Liu T, Zhao H, Rao Z, Lou Z#. Crystal structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis. FASEB journal, 2011, 25(5): 1577-1584.
5. Shan S, Chen X. Crystallization and preliminary X-ray analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis. Acta crystallographica Section F, 2011, 67(Pt 7): 821-823.
6. Wang Y., Liu S., Sun L., Xu N., Shan S., Wu F., Liang X., Huang Y., Luk E., Wu C., Zhou Z , Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement. PLOS biology, 2019, 17(5): e3000277.
7. Mao *Z, Pan L*, Wang W*, Sun J, Shan S, Dong Q, Liang X, Dai L, Ding X, Chen S, Zhang Z#, Zhu B#, Zhou Z#. Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z. Cell research 2014, 24(4): 389-399.
(From Shan Shan, December 28, 2020)