Lu Yang (Resigned), Ph.D, Associate Professor
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Member of the Youth Innovation Promotion Association of CAS
State Key Laboratory of Brain & Cognitive Sciences, IBP
Research Interests: Cellular basis and molecular regulation of neurogenesisin brain development and brain disease and brain disease
Email: luyang@ibp.ac.cn
Tel:
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
2007.09 - 2011.07 China Agricultural University, B.S. in Life Science
2011.09 - 2017.07 Peking University, Ph.D. in Life Science College
2017.07 - 2018 Institute of Biophysics, Associate Professor
- Awards
- Membership in Academies & Societies
- Research Interests
oRGcells exist extensively in non-human primates and human cortex, and were thought to be key factors of evolution from non-gyrus to gyrus. We used single-cell RNA-seq to screen the marker genes of oRG cells, and the conditional overexpression of the genes confirmed the genes could promote the proliferation of mouse neural progenitor cells and induce cortical thickening and gyrification in postnatal mice.
- Grants
- Selected Publications
1. Liu, J., W. Liu, L. Yang, Q. Wu, H. Zhang, A. Fang, L. Li, X. Xu, L. Sun, J. Zhang, F. Tang and X. Wang (2017). The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. Cell Stem Cell.（Co First Author）
2. Dai, H. Q., B. A. Wang, L. Yang, J. J. Chen, G. C. Zhu, M. L. Sun, H. Ge, R. Wang, D. L. Chapman, F. Tang, X. Sun and G. L. Xu (2016). TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature 538(7626): 528-532.（Co Fisrt Author）
3. Yang, L., Z. C. Ma, C. Cao, Y. H. Zhang, X. L. Wu, R. Lee, B. Q. Hu, L. Wen, H. Ge, Y. Y. Huang, K. Q. Lao and F. C. Tang (2017). MR-seq: measuring a single cell's transcriptome repeatedly by RNA-seq. Science Bulletin 62(6): 391-398.（Co Fisrt Author）
4. Wang, L., J. Zhang, J. Duan, X. Gao, W. Zhu, X. Lu, L. Yang, J. Zhang, G. Li, W. Ci, W. Li, Q. Zhou, N. Aluru, F. Tang, C. He, X. Huang and J. Liu (2014). Programming and inheritance of parental DNA methylomes in mammals. Cell 157(4): 979-991.
5. Streets, A. M., X. Zhang, C. Cao, Y. Pang, X. Wu, L. Xiong, L. Yang, Y. Fu, L. Zhao, F. Tang and Y. Huang (2014). Microfluidic single-cell whole-transcriptome sequencing. Proc Natl Acad Sci U S A 111(19): 7048-7053.
6. Yan, L., M. Yang, H. Guo, L. Yang, J. Wu, R. Li, P. Liu, Y. Lian, X. Zheng, J. Yan, J. Huang, M. Li, X. Wu, L. Wen, K. Lao, R. Li, J. Qiao and F. Tang (2013). Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Bio l20(9): 1131-1139.
7. Zhang, R. R., Q. Y. Cui, K. Murai, Y. C. Lim, Z. D. Smith, S. Jin, P. Ye, L. Rosa, Y. K. Lee, H. P. Wu, W. Liu, Z. M. Xu, L. Yang, Y. Q. Ding, F. Tang, A. Meissner, C. Ding, Y. Shi and G. L. Xu (2013). Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell 13(2): 237-245.
(From Lu Yang, February 1, 2018)