2005.09 - 2009.06  B.S., College of Life Sciences, Wuhan University

2009.09 - 2015.12  Ph.D, Institute of Biophysics, Chinese Academy of Sciences

2016.01 - 2018.12  Assistant Professor, Institute of Biophysics, Chinese Academy of Sciences

2019.01 - 2023.12  Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

2024/01-                Professor, Institute of Biophysics, Chinese Academy of Sciences

1. Glycoproteins of enveloped virus determine viral entry into host cells and host tropism, which is an important target for therapeutics development. Investigating the structure information of virus glycoprotein in receptor recognition and membrane fusion, should help to understand the virus entry mechanism and develop effective vaccine and drugs.

2. The host immune system deploys a variety of proteins to defense pathogen invasion. Structural and functional study of these proteins and related protein complexes would help to uncover the mechanism of host immune response and the regulatory role of virus protein to escape the host immune attack.

1. Cao, D.^#, Ma, B.^#, Cao, Z.^#, Zhang, X.*, and Xiang, Y.*. Structure of Semliki Forest virus in complex with its receptor VLDLR. Cell, 2023.

2. Su, X.^#, Cao, D.^#, Pan, X.*, Shi, L., Liu, Z., Dall'Osto, L., Bassi, R., Zhang, X.* and Li, M.*. Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana. Molecular Plant, 2022.

3. Cao D^#, Han X^#, Fan X^#, Xu R-M*, and Zhang, X*. Structrual basis for nucleosome-mediated inhibition of cGAS activity. Cell Research, 2020.

4. Fan X^#, Cao D^#*, Kong L, and Zhang X*. Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein. Nature Communications, 2020, 11, 3618.

5. Gao Y^#, Cao D^#, Zhu J, Feng H, Luo X, Liu S, Yan X-X, Zhang X*, and Gao P*. Structural insights into assembly, operation and inhibition of a type I restriction-modification system. Nature Microbiology, 2020, 5, 1107-1118.

6. Pan X^#, Cao D^#, Xie F^#, Xu F^#, Su X, Mi H*, Zhang X*, and Li M*. Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase. Nature Communications, 2020, 11, 610.

7. Cao P^#, Cao D^#, Si L, Su X, Tian L, Chang W, Liu Z, Zhang X*, and Li M*. Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex. Nature Plants, 2020, 6, 167-176.

8. Yuan Y^#, Cao D^#, Zhang Y^#, Ma J^#, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y*, Zhang X*, and Gao GF*. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains. Nature Communications, 2017, 8, 15092.

9. Cao D, Wang M, Qiu X, Liu D, Jiang H, Yang N*, and Xu R-M.* (2015). Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol. Genes & development, 2015, 29, 1316-1325.

10. Cao D^#, Yang N*. (2015) Structure and Catalytic Mechanisms of Histone Deacetylases. Progress in Biochemistry and Biophysics, 2015, 42, 978-93.

(From Duanfang Cao, January 31, 2023)