1999.09 - 2003.06  B.Sc. in Biology, College of Life Sciences, Wuhan University, Wuhan 　　

2003.09 - 2008.06  Ph.D in Biochemistry and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 　　

2008.07 - 2011.11  Research Associate, Institute of Biophysics, Chinese Academy of Sciences, Beijing 　　

2012.01 -                Associate Professor, Institute of Biophysics, Chinese Academy of Sciences, Beijing 　　

2015.12 - 2016.12  Visiting Scholar, The Scripps Research Institute, La Jolla, CA, USA 　　

Disulfide formation is one of the key rate-limiting steps in oxidative protein folding, which is vital for the stability of many secretory and cell-surface proteins and redox regulation of protein activities in some cases. Dr. Xi Wang worked on the structure-function relationships and molecular mechanisms of essential enzymes in oxidative protein folding. His recent research interests also include studying the proteostasis regulation and its impacts on human healthspan through a multidisciplinary application of cell biological, biochemical, and structural approaches. 　　

1. NSFC General Program, “Regulation of redox homeostasis in the endoplasmic reticulum via oxidoreductases”, 2019-2022　　　　

2. NSFC General Program, “Molecular mechanism and structural basis of peroxiredoxin 4 mediated oxidative protein folding pathway”, 2014-2017

3. NSFC Young Scientists Program, “Roles of human quiescin-sulfhydryl oxidase1 in oxidative protein folding and quality control”, 2010-2012 　　

1. Jiaojiao Yu, Tao Li, Yu Liu, Xi Wang, Jianchao Zhang, Xi'e Wang, Guizhi Shi, Jizhou Lou, Likun Wang, Chih-chen Wang, Lei Wang (2020) Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO J 39: e103841

2. Shili Xu, Yajing Liu, Kai Yang, Hanxiao Wang, Andrea Shergalis, Anahita Kyani, Armand Bankhead III, Shuzo Tamura, Suhui Yang, Xi Wang, Chih-chen Wang, Alnawaz Rehemtulla, Mats Ljungman, Nouri Neamati (2019) Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes. Theranostics 9:2282-2298.

3. Yini Zhang, Tao Li, Lihui Zhang, Fugen Shangguan, Guizhi Shi, Xun Wu, Ya Cui, Xi'e Wang, Xi Wang, Yongzhang Liu, Bin Lu, Taotao Wei, Chih-chen Wang, Lei Wang (2019) Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer. EBioMedicine 41:408-419.

4. Jianchao Zhang, Qinyu Zhu, Xi'e Wang, Jiaojiao Yu, Xinxin Chen, Jifeng Wang, Xi Wang, Junyu Xiao, Chih-chen Wang, Lei Wang (2018) Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α. EMBO J., 37:e98699.　　

5. Kai Yang, De-Feng Li, Xi’e Wang, Jinzhao Liang, Roberto Sitia, Chih-chen Wang^#, Xi Wang^# (2016) Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention. Structure, 24:1755-1765. (^#co-corresponding author)

6. Lei Wang*, Xi Wang*, Chih-chen Wang (2015) Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone. Free Radic Biol Med, 83:305-13. (*co-first author)

7. Li Zhu, Kai Yang, Xi’e Wang, Xi Wang^# and Chih-chen Wang^# (2014) A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding. PLoS One, 9:e105529. (^#co-corresponding author)

8. Shang Yang*, Xi Wang*, Lei Cui, Xiang Ding, Lili Niu, Fuquan Yang, Chao Wang, Chih-chen Wang, Jizhong Lou (2014) Compact conformations of human protein disulfide isomerase. PLoS One, 9:e103472. (*co-first author)

9. Xi Wang*, Likun Wang*, Xi’e Wang, Fei Sun and Chih-chen Wang (2012) Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. Biochem J., 441:113–118. (*co-first author)

10. Chao Wang, Sihong Chen, Xi Wang, Lei Wang, A. Katrine Wallis, Robert B. Freedman and Chih-chen Wang (2010) Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance. J Biol Chem., 285: 26788-97.

11. Guoping Ren*, Xi Wang*, Shufeng Hao, Hongyu Hu and Chih-chen Wang (2007) Translocation of alpha-synuclein expressed in Escherichia coli. J Bacteriol., 189: 2777-86. (*co-first author)

(From Xi Wang, November 10, 2021)